Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies
NCT03629756 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD) and clinical activity of etrumadenant (AB928) in combination with zimberelimab (AB122) (an anti-PD-1 antibody) in participants with advanced malignancies.
Conditions Studied
Interventions
- DRUG Zimberelimab
- DRUG Etrumadenant
Study Locations (15)
Texas
- Texas Oncology, P.A. - Fort Worth Cancer Center — Fort Worth
- Texas Oncology, P.A. - San Antonio Medical Center — San Antonio
- Texas Oncology, P.A. - Tyler — Tyler
California
- University of California, Los Angeles — Los Angeles
- The Angeles Clinic and Research Institute — Los Angeles
Michigan
- University of Michigan — Ann Arbor
- QUEST Research Institute — Royal Oak
Arizona
- Scottsdale Healthcare Hospitals dba HonorHealth — Scottsdale
Colorado
- Rocky Mountain Cancer Centers (Midtown) — Denver
North Carolina
- Carolina BioOncology Institute — Huntersville
South Carolina
- Prisma Health — Greenville
Washington
- Medical Oncology Associates dba Summit Cancer Centers — Spokane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2018-07-24 |
| Est. Completion | 2021-09-03 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03629756
The ClinicalTrials.gov registry entry for NCT03629756 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcus Biosciences, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Zimberelimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03629756 reports 15 study locations spanning 11 distinct geographic areas — top geographies include Texas, California, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03629756 about?
NCT03629756 is a clinical study titled "A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies". This is a Phase 1, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD) and clinical activity of etrumadenant (AB928) in combination with zimberelimab (AB122) (an anti-PD-1 antibody) in participants with advanced malign...
What is the current status of trial NCT03629756?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2018-07-24. Estimated completion is 2021-09-03.
What conditions does trial NCT03629756 study?
This clinical trial studies the following conditions: Breast Cancer, Colorectal Cancer, Ovarian Cancer, Melanoma, Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03629756?
The interventions under investigation include: Zimberelimab (DRUG), Etrumadenant (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03629756?
This trial is sponsored by Arcus Biosciences, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03629756 being conducted?
This trial has 15 study locations across Arizona, California, Colorado, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.