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NCT05902520 · ClinicalTrials.gov registry record · Phase 1
Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
A Phase 1 study of Lung Cancer and Colorectal Cancer, sponsored by AgonOx.
- Active
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT05902520: Active Phase 1 study of Lung Cancer and Colorectal Cancer, sponsored by AgonOx.
NCT05902520 is a Phase 1 study of Lung Cancer and Colorectal Cancer that is active but no longer recruiting, run by AgonOx. The registered enrollment target is 18 participants, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05902520, a Phase 1 study of Lung Cancer and Colorectal Cancer, is active but no longer recruiting, sponsored by AgonOx.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
The subject of this study is the adoptive transfer of selected autologous tumor infiltrating lymphocytes (TIL) after in vitro expansion for the treatment of solid tumor malignancies. The TIL selection process is based on evidence showing that CD8+ TIL which co-express both CD39 and CD103 harbor the bulk of tumor-reactivity and that the remaining CD8 TIL is mainly composed of non-tumor reactive bystander cells. All of the expanded TIL that are produced (1-40 billion are expected) will be delivered in the form of a cell suspension to the participants by intravenous infusion. It is proposed that these selected TIL will produce a more potent and efficacious treatment of late-stage cancer.
Primary Outcome
Frequency and severity of treatment-related adverse events as assessed by CTCAE v5.0 in participants treated with DP CD8 TIL adoptive cell therapy with and without ex vivo siRNA PD-1 modulation after lymphodepleting chemotherapy and followed by high-dose and low-dose IL-2.
Conditions Studied
Interventions
- BIOLOGICAL DP CD8 TIL
- BIOLOGICAL DP CD8 TIL KD
- BIOLOGICAL Low dose IL-2
Study Locations (1)
Oregon
- Providence Portland Medical Center - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2023-06-19 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
What the registry record for NCT05902520 still lists
NCT05902520 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (98% lower).
The record links to 6 conditions, with Lung Cancer appearing as the primary indexed condition, and to 3 interventions - of which DP CD8 TIL is the first listed.
NCT05902520 reports a single indexed study location in Oregon.
Frequently Asked Questions
What is clinical trial NCT05902520 about?
NCT05902520 is a clinical study titled "Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors". The subject of this study is the adoptive transfer of selected autologous tumor infiltrating lymphocytes (TIL) after in vitro expansion for the treatment of solid tumor malignancies. The TIL selection process is based on evidence showing that CD8+ TIL which co-express both CD39 and CD103 harbor the ...
What is the current status of trial NCT05902520?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2023-06-19. Estimated completion is 2026-12-31.
What conditions does trial NCT05902520 study?
This clinical trial studies the following conditions: Lung Cancer, Colorectal Cancer, Melanoma, Gynecologic Cancer, HNSCC.
What interventions are being tested in trial NCT05902520?
The interventions under investigation include: DP CD8 TIL (BIOLOGICAL), DP CD8 TIL KD (BIOLOGICAL), Low dose IL-2 (BIOLOGICAL).
Who is sponsoring clinical trial NCT05902520?
This trial is sponsored by AgonOx, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05902520 being conducted?
This trial has 1 study location across Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05902520's enrollment target sits among peer trials
18 367th of 409 higher than 40 of 409 other Lung Cancer trials
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