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NCT06237881 · ClinicalTrials.gov registry record · Phase 1
A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors
A Phase 1 study of Melanoma and Advanced Solid Tumor, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT06237881: Active Phase 1 study of Melanoma and Advanced Solid Tumor, sponsored by M.D. Anderson Cancer Center.
NCT06237881 is a Phase 1 study of Melanoma and Advanced Solid Tumor that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 15 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06237881, a Phase 1 study of Melanoma and Advanced Solid Tumor, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
To learn if KSQ-001EX is safe to give to participants with advanced forms of solid tumors.
Primary Outcome
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Interleukin-2
- DRUG KSQ-001EX
Study Locations (1)
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2024-01-31 |
| Est. Completion | 2029-01-01 |
| Phase | Phase 1 |
What the registry record for NCT06237881 still lists
NCT06237881 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (98% lower).
The record links to 4 conditions, with Melanoma appearing as the primary indexed condition, and to 4 interventions - of which Cyclophosphamide is the first listed.
NCT06237881 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06237881 about?
NCT06237881 is a clinical study titled "A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors". To learn if KSQ-001EX is safe to give to participants with advanced forms of solid tumors.
What is the current status of trial NCT06237881?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2024-01-31. Estimated completion is 2029-01-01.
What conditions does trial NCT06237881 study?
This clinical trial studies the following conditions: Melanoma, Advanced Solid Tumor, Lung Neoplasms, Head and Neck Neoplasms.
What interventions are being tested in trial NCT06237881?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Interleukin-2 (DRUG), KSQ-001EX (DRUG).
Who is sponsoring clinical trial NCT06237881?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06237881 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06237881's enrollment target sits among peer trials
15 241st of 266 higher than 24 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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