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ClinicalTrials.gov 94 recruiting now official registry

Malignant Solid Neoplasm clinical trials

94 of 177 indexed Malignant Solid Neoplasm trials are currently recruiting.

177 US clinical trials · 94 currently recruiting

Malignant Solid Neoplasm is the subject of 177 registered US clinical trials on ClinicalTrials.gov, 94 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 42 of these trials.

The research picture

Malignant Solid Neoplasm has 177 registered US clinical trials, 94 of them open to new participants right now, about 53% of the total.

94
recruiting participants now
53%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
42
top sponsor: M.D. Anderson Cancer Center
Phase 124Phase 222Phase 312Phase 42

Active & Recent Trials

177 total, page 3 of 4

ACTIVE NOT RECRUITING NA 590 participants

Understanding Challenges, Behavioral Patterns, and Preferences Toward Participation in Clinical Trials in Minority Patient Populations: Development of a Personalized Clinical Trial Educational Platform to Increase Participation in Clinical Trials Among Underserved Cancer Patients

Mayo Clinic

NCT04630431

ACTIVE NOT RECRUITING 549 participants

Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer

Children's Oncology Group

NCT05228275

ACTIVE NOT RECRUITING NA 465 participants

HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics

City of Hope Medical Center

NCT04905082

ACTIVE NOT RECRUITING Phase 3 427 participants

Quit2Heal Smartphone App in Helping Cancer Patients Quit Smoking

Fred Hutchinson Cancer Center

NCT04409236

ACTIVE NOT RECRUITING Phase 3 422 participants

Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

University of Rochester NCORP Research Base

NCT03996265

ACTIVE NOT RECRUITING NA 398 participants

Home Base Telemonitoring in Gastrointestinal, Genitourinary, or Gynecologic Cancer Patients Undergoing Abdominal Surgery

City of Hope Medical Center

NCT04596384

ACTIVE NOT RECRUITING Phase 3 387 participants

Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study

Children's Oncology Group

NCT04089358

ACTIVE NOT RECRUITING NA 374 participants

Testing Counseling and Mobile Health Interventions to Improve Physical Activity and Diet Quality in Survivors of Childhood Cancer

Fred Hutchinson Cancer Center

NCT05075759

ACTIVE NOT RECRUITING Phase 3 300 participants

Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer

Children's Oncology Group

NCT03223753

ACTIVE NOT RECRUITING NA 297 participants

Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE

University of Washington

NCT05012124

ACTIVE NOT RECRUITING 274 participants

Well-being in Cancer Patients With Neuropathy During COVID-19 Who Participated in Prior Clinical Trials

M.D. Anderson Cancer Center

NCT04650178

ACTIVE NOT RECRUITING 200 participants

Patient Reported Symptom Control With THC or CBD Use

M.D. Anderson Cancer Center

NCT04875286

ACTIVE NOT RECRUITING 200 participants

Survey Assessment of Patient and Provider Impressions of Telemedicine in Radiation Oncology

M.D. Anderson Cancer Center

NCT05496972

ACTIVE NOT RECRUITING Phase 2 199 participants

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

National Cancer Institute (NCI)

NCT05554367

ACTIVE NOT RECRUITING 180 participants

Comprehensive Nutritional Geriatric Assessments in Identifying Malnutrition in Older Cancer Participants

M.D. Anderson Cancer Center

NCT03035604

ACTIVE NOT RECRUITING Phase 1 173 participants

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT03217747

ACTIVE NOT RECRUITING Phase 1 152 participants

Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors

National Cancer Institute (NCI)

NCT02496208

ACTIVE NOT RECRUITING Phase 3 150 participants

Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients

M.D. Anderson Cancer Center

NCT04188418

ACTIVE NOT RECRUITING NA 149 participants

Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors

City of Hope Medical Center

NCT05138991

ACTIVE NOT RECRUITING NA 133 participants

Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy

University of Rochester NCORP Research Base

NCT04888988

ACTIVE NOT RECRUITING Phase 1 126 participants

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT02444741

ACTIVE NOT RECRUITING 110 participants

Parental Attitudes and Beliefs Regarding Risks Associated With Opioid Use in Children With Cancer

M.D. Anderson Cancer Center

NCT05055011

ACTIVE NOT RECRUITING NA 107 participants

Patient Perceptions of the Relational Empathy of Healthcare Practitioners From the Department of Emergency Medicine During the COVID-19 Pandemic

M.D. Anderson Cancer Center

NCT05102656

ACTIVE NOT RECRUITING Early Phase 1 100 participants

Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer

City of Hope Medical Center

NCT05868486

ACTIVE NOT RECRUITING Phase 2 88 participants

PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy

Academic and Community Cancer Research United

NCT05246670

ACTIVE NOT RECRUITING Phase 1 86 participants

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

National Cancer Institute (NCI)

NCT05286801

ACTIVE NOT RECRUITING Phase 4 84 participants

Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain

M.D. Anderson Cancer Center

NCT04296305

ACTIVE NOT RECRUITING 83 participants

Vincristine Pharmacokinetics in Infants

Children's Oncology Group

NCT05359237

ACTIVE NOT RECRUITING NA 76 participants

Transcutaneous Sensors for the Detection of Cancer-Related Lymphedema, Project Limb Rescue Study

Ohio State University Comprehensive Cancer Center

NCT06305884

ACTIVE NOT RECRUITING Phase 1 75 participants

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

National Cancer Institute (NCI)

NCT01989585

ACTIVE NOT RECRUITING Phase 2 72 participants

Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters

National Cancer Institute (NCI)

NCT06009926

ACTIVE NOT RECRUITING Phase 2 68 participants

Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer

M.D. Anderson Cancer Center

NCT01628029

ACTIVE NOT RECRUITING Phase 1 57 participants

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02453620

ACTIVE NOT RECRUITING Phase 2 49 participants

Donor Cytomegalovirus-Specific Cytotoxic T-Lymphocytes in Treating Patients With a Persistent Cytomegalovirus Infection

M.D. Anderson Cancer Center

NCT02210078

ACTIVE NOT RECRUITING Phase 2 48 participants

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

Thomas Jefferson University

NCT04111172

ACTIVE NOT RECRUITING Phase 1 47 participants

Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourinary Cancer or Melanoma

M.D. Anderson Cancer Center

NCT04407247

ACTIVE NOT RECRUITING 41 participants

Preliminary Testing of the MD Anderson Symptom Inventory (Adolescent Version)

M.D. Anderson Cancer Center

NCT02515383

ACTIVE NOT RECRUITING 41 participants

Precision Performance Status Compared With ECOG Performance Status

University of Southern California

NCT07082257

ACTIVE NOT RECRUITING NA 36 participants

Telementoring Intervention (ECHO) for the Transformation of Professional Engagement, Practice Efficiency, and Community Building Through Team Meetings in Diagnostic Imaging Clinicians

M.D. Anderson Cancer Center

NCT04196972

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)

National Cancer Institute (NCI)

NCT06136897

ACTIVE NOT RECRUITING Phase 2 35 participants

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Mutations or Fusions (MATCH - Subprotocol K2)

National Cancer Institute (NCI)

NCT06351371

ACTIVE NOT RECRUITING Phase 2 35 participants

Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma

M.D. Anderson Cancer Center

NCT04940299

ACTIVE NOT RECRUITING Phase 2 30 participants

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

M.D. Anderson Cancer Center

NCT03449108

ACTIVE NOT RECRUITING Phase 1 26 participants

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

Jonsson Comprehensive Cancer Center

NCT04459273

ACTIVE NOT RECRUITING Phase 1 25 participants

18F-Fluoroazomycin Arabinoside PET-CT in Diagnosing Solid Tumors in Patients

M.D. Anderson Cancer Center

NCT03168737

ACTIVE NOT RECRUITING Phase 2 24 participants

Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant Tumors

National Cancer Institute (NCI)

NCT03878095

ACTIVE NOT RECRUITING Phase 2 22 participants

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)

National Cancer Institute (NCI)

NCT06360588

ACTIVE NOT RECRUITING NA 20 participants

A Mobile Application, Oncpatient, to Assist Patients Undergoing Radiation Therapy

City of Hope Medical Center

NCT05173961

ACTIVE NOT RECRUITING NA 20 participants

The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer

City of Hope Medical Center

NCT05023993

ACTIVE NOT RECRUITING Phase 1 15 participants

Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

OHSU Knight Cancer Institute

NCT03361436

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 22
Phase 3 12
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Solid Neoplasm Trial Landscape

177 indexed Malignant Solid Neoplasm studies · 94 recruiting (53%).

Phase mix: 14 late (III/IV) vs 46 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (42 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Solid Neoplasm?

PlainTrial tracks 177 US clinical trials for Malignant Solid Neoplasm, of which 94 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.