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ClinicalTrials.gov 94 recruiting now official registry

Malignant Solid Neoplasm clinical trials

94 of 177 indexed Malignant Solid Neoplasm trials are currently recruiting.

177 US clinical trials · 94 currently recruiting

Malignant Solid Neoplasm is the subject of 177 registered US clinical trials on ClinicalTrials.gov, 94 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 42 of these trials.

The research picture

Malignant Solid Neoplasm has 177 registered US clinical trials, 94 of them open to new participants right now, about 53% of the total.

94
recruiting participants now
53%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
42
top sponsor: M.D. Anderson Cancer Center
Phase 124Phase 222Phase 312Phase 42

Active & Recent Trials

177 total, page 2 of 4

RECRUITING Phase 3 140 participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Mayo Clinic

NCT03750227

RECRUITING 134 participants

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

Mayo Clinic

NCT07477886

RECRUITING NA 125 participants

Communication Issues in Patient and Provider Discussions of Immunotherapy

Emory University

NCT05873608

RECRUITING NA 114 participants

Weighted Blanket Use to Reduce Anxiety in Oncology Patients

Ohio State University Comprehensive Cancer Center

NCT06089408

RECRUITING Phase 3 105 participants

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

Children's Oncology Group

NCT05711667

RECRUITING 100 participants

Investigating Memory and Physical Activity After Cancer Treatment in Survivors of Adolescent and Young Adult Cancers

Mayo Clinic

NCT06880861

RECRUITING 100 participants

Observational Study of Sex Differences in Symptoms During Immune Checkpoint Inhibitor Treatment for People With Cancer

OHSU Knight Cancer Institute

NCT06562777

RECRUITING NA 85 participants

Intravital Microscopy in Human Solid Tumors

Mayo Clinic

NCT03823144

RECRUITING NA 80 participants

A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients

University of Michigan Rogel Cancer Center

NCT07291414

RECRUITING NA 78 participants

Acupressure for the Reduction of Anxiety in Patients Receiving Cancer-Directed Therapy

Mayo Clinic

NCT06723041

RECRUITING NA 76 participants

Transportation for Cancer Care Navigation Tool for Reducing Travel Barriers Among Patients With Solid Tumors Receiving Radiation Therapy

Emory University

NCT06541158

RECRUITING NA 72 participants

CREATE: Art for Children With Cancer

OHSU Knight Cancer Institute

NCT06342453

RECRUITING Phase 1 72 participants

Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines

M.D. Anderson Cancer Center

NCT02962661

RECRUITING Phase 2 70 participants

Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers

Emory University

NCT06492070

RECRUITING Phase 1 70 participants

Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia

M.D. Anderson Cancer Center

NCT04565665

RECRUITING Phase 2 70 participants

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

National Cancer Institute (NCI)

NCT06126276

RECRUITING NA 60 participants

Exercise Program (TEAM Me) for the Improvement of Movement and Mobility in Pediatric and Adolescent and Young Adult Patients With Cancer Undergoing a Blood Stem Cell Transplant

M.D. Anderson Cancer Center

NCT04678427

RECRUITING NA 60 participants

Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting

City of Hope Medical Center

NCT07126301

RECRUITING Phase 3 60 participants

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

Children's Oncology Group

NCT06513962

RECRUITING Phase 2 60 participants

Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers

City of Hope Medical Center

NCT05722288

RECRUITING NA 60 participants

Solution-Focused Brief Therapy for Support of Psychological Distress in Adolescent and Young Adult Cancer Survivors

University of Michigan Rogel Cancer Center

NCT06941324

RECRUITING NA 60 participants

Group Curriculum for Improving Survivorship Outcomes in Adolescent and Young Adult Cancer Survivors

Mayo Clinic

NCT05584449

RECRUITING Phase 2 60 participants

Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas

Roswell Park Cancer Institute

NCT06202066

RECRUITING Phase 1 53 participants

Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction

Roswell Park Cancer Institute

NCT06306638

RECRUITING NA 50 participants

Different Types of Massage Therapy to Reduce Anxiety During Chemotherapy Infusion in Patients With Cancer

City of Hope Medical Center

NCT07184294

RECRUITING NA 50 participants

A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment

University of Michigan Rogel Cancer Center

NCT07365007

RECRUITING Early Phase 1 50 participants

L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance

City of Hope Medical Center

NCT07220447

RECRUITING 50 participants

Data-Driven Strategies for Patient Engagement About Cancer Clinical Trials

University of Southern California

NCT07456436

RECRUITING NA 50 participants

Telehealth Intervention for Improving Distress and Financial Toxicity in the Caregivers

Wake Forest University Health Sciences

NCT06709404

RECRUITING NA 44 participants

Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors

City of Hope Medical Center

NCT06500377

RECRUITING 40 participants

Voices: Messages of Wisdom and Hope in the Face of Illness

Mayo Clinic

NCT07381179

RECRUITING 38 participants

Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy

Masonic Cancer Center, University of Minnesota

NCT06414278

RECRUITING Phase 2 32 participants

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

City of Hope Medical Center

NCT05830058

RECRUITING NA 30 participants

Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care

University of California, San Francisco

NCT05641961

RECRUITING Phase 1 30 participants

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients

M.D. Anderson Cancer Center

NCT05101213

RECRUITING NA 30 participants

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

Mayo Clinic

NCT07291011

RECRUITING Early Phase 1 30 participants

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

M.D. Anderson Cancer Center

NCT06184321

RECRUITING 30 participants

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Mayo Clinic

NCT06640010

RECRUITING NA 28 participants

Virtual Reality for Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation

Roswell Park Cancer Institute

NCT06798701

RECRUITING 24 participants

Ex Vivo Expansion (ACT-X)

Mayo Clinic

NCT07137312

RECRUITING NA 24 participants

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Mayo Clinic

NCT07221409

RECRUITING NA 20 participants

Virtual Art Therapy Assisted Re-Integration to Improve Biopsychosocial Outcomes in Adolescent and Young Adult Cancer Survivors, AVATARS Trial

Mayo Clinic

NCT07089927

RECRUITING 20 participants

Assessing Effect of Spinal Cord Stimulation on Pain and Quality of Life With Chemotherapy-Induced Peripheral Neuropathy

Mayo Clinic

NCT05411523

RECRUITING 10 participants

Formulating Expert Consensus Guidelines in Cancer Care Using the Delphi Method

M.D. Anderson Cancer Center

NCT05054413

ACTIVE NOT RECRUITING 13,378 participants

Well-Being and Health-Related Quality of Life in Cancer Patients and Survivors During the COVID-19 Pandemic

M.D. Anderson Cancer Center

NCT04500600

ACTIVE NOT RECRUITING 2,100 participants

An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study

University of Rochester NCORP Research Base

NCT05364086

ACTIVE NOT RECRUITING 1,877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

National Cancer Institute (NCI)

NCT04387656

ACTIVE NOT RECRUITING 1,242 participants

Impact of the COVID-19 Pandemic and HRQOL in Cancer Patients and Survivors

M.D. Anderson Cancer Center

NCT04447222

ACTIVE NOT RECRUITING 625 participants

Financial Toxicity in Cancer Patients

M.D. Anderson Cancer Center

NCT04592250

ACTIVE NOT RECRUITING NA 600 participants

Yoga Program for Improving the Quality of Life in Couples Coping With Cancer

M.D. Anderson Cancer Center

NCT04607590

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 22
Phase 3 12
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Solid Neoplasm Trial Landscape

177 indexed Malignant Solid Neoplasm studies · 94 recruiting (53%).

Phase mix: 14 late (III/IV) vs 46 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (42 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Solid Neoplasm?

PlainTrial tracks 177 US clinical trials for Malignant Solid Neoplasm, of which 94 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.