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ClinicalTrials.gov 94 recruiting now official registry

Malignant Solid Neoplasm clinical trials

94 of 177 indexed Malignant Solid Neoplasm trials are currently recruiting.

177 US clinical trials · 94 currently recruiting

Malignant Solid Neoplasm is the subject of 177 registered US clinical trials on ClinicalTrials.gov, 94 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 42 of these trials.

The research picture

Malignant Solid Neoplasm has 177 registered US clinical trials, 94 of them open to new participants right now, about 53% of the total.

94
recruiting participants now
53%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
42
top sponsor: M.D. Anderson Cancer Center
Phase 124Phase 222Phase 312Phase 42

Active & Recent Trials

177 total, page 1 of 4

RECRUITING NA 27,500 participants

Identifying and Caring for Individuals With Inherited Cancer Syndrome

OHSU Knight Cancer Institute

NCT04494945

RECRUITING NA 24,000 participants

The Vanguard Study: Testing a New Way to Screen for Cancer

National Cancer Institute (NCI)

NCT06995898

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING 10,000 participants

A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

Mayo Clinic

NCT06192875

RECRUITING 6,150 participants

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

Mayo Clinic

NCT06304168

RECRUITING 5,000 participants

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

National Cancer Institute LAO

NCT02474160

RECRUITING 5,000 participants

Impact of Physician Behavior on Cancer Distress

Mayo Clinic

NCT07325006

RECRUITING 5,000 participants

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

M.D. Anderson Cancer Center

NCT00991094

RECRUITING 3,000 participants

Role of Gut Microbiome in Cancer Therapy

Mayo Clinic

NCT05112614

RECRUITING 2,062 participants

Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

SWOG Cancer Research Network

NCT04871542

RECRUITING NA 2,000 participants

A Virtual Community Health Educator for Increasing Clinical Trial Referrals Among Cancer Patients and Their Caregivers

Mayo Clinic

NCT07126496

RECRUITING NA 1,800 participants

Cancer Genetic Testing in Ethnic Populations

Mayo Clinic

NCT04475640

RECRUITING 1,500 participants

Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

University of Washington

NCT01050504

RECRUITING 1,000 participants

Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

Mayo Clinic

NCT06353191

RECRUITING NA 800 participants

Access to Genetic Testing in Underserved Patients With Cancer

University of Southern California

NCT06422455

RECRUITING Phase 3 777 participants

Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy

SWOG Cancer Research Network

NCT05642611

RECRUITING NA 760 participants

Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)

ECOG-ACRIN Cancer Research Group

NCT06295367

RECRUITING Phase 3 668 participants

Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial

University of Rochester

NCT05006482

RECRUITING NA 660 participants

A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors (ASCENT)

Mayo Clinic

NCT06198010

RECRUITING NA 600 participants

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

NRG Oncology

NCT06279013

RECRUITING 600 participants

The Effect of COVID-19 Pandemic on Adolescent and Young Adult Cancer Patients and Survivors

M.D. Anderson Cancer Center

NCT04551378

RECRUITING NA 578 participants

Web-Based Toolkit to Improve Cancer-Related Emotional Distress and Anxiety in Rural Older Cancer Survivors

Northwestern University

NCT07290543

RECRUITING NA 414 participants

Expressive Writing for the Management of Stress in Cancer Survivors

M.D. Anderson Cancer Center

NCT04776941

RECRUITING Phase 3 400 participants

Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment

University of Rochester NCORP Research Base

NCT04829539

RECRUITING NA 400 participants

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

Mayo Clinic

NCT06015932

RECRUITING NA 400 participants

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

Fred Hutchinson Cancer Center

NCT04515810

RECRUITING NA 384 participants

Increasing Knowledge and Interest in Cancer Clinical Trials

Hayley Thompson

NCT06501040

RECRUITING Phase 2 380 participants

Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy

M.D. Anderson Cancer Center

NCT04560673

RECRUITING 350 participants

INTERogating Cancer for Etiology, Prevention and Therapy Navigation

Mayo Clinic

NCT06008392

RECRUITING Phase 1 350 participants

Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

NRG Oncology

NCT03997370

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING NA 300 participants

Genetic Testing for the Prevention of Cancer in Indigenous American Communities (JUNIPER Trial)

Mayo Clinic

NCT06569316

RECRUITING NA 300 participants

Evaluating a Mobile Health Application Intervention for Caregiver Instruction in Manual Therapy for Chemotherapy-Induced Peripheral Neuropathy

Mayo Clinic

NCT06945380

RECRUITING 260 participants

Wearable Activity Tracking to Curb Hospitalizations

University of California, San Francisco

NCT06587100

RECRUITING NA 256 participants

Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure

M.D. Anderson Cancer Center

NCT02464696

RECRUITING 250 participants

The Impact of COVID-19 on Pulmonary Procedures

M.D. Anderson Cancer Center

NCT05022446

RECRUITING NA 240 participants

Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study

City of Hope Medical Center

NCT05772130

RECRUITING NA 216 participants

Telemedicine for Improvement of Care for Older Adults With Cancer in the Underserved Community, The GAIN-S Trial

City of Hope Medical Center

NCT06022965

RECRUITING NA 208 participants

Outreach Project to Connect Underrepresented Populations to Clinical Trials at Ohio State University, CUSP2CT Project Trial

Ohio State University Comprehensive Cancer Center

NCT06314672

RECRUITING NA 200 participants

Community-Based Physical Activity Intervention for Underserved Cancer Survivors

Roswell Park Cancer Institute

NCT06206863

RECRUITING NA 200 participants

Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)

Ohio State University Comprehensive Cancer Center

NCT05178472

RECRUITING 200 participants

Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

AIDS Malignancy Consortium

NCT05663502

RECRUITING NA 200 participants

Pre-Operative Guided Meditation to Reduce Pre-Operative Anxiety in Patients Undergoing Cancer-Directed Surgery

Ohio State University Comprehensive Cancer Center

NCT06949943

RECRUITING 200 participants

Evaluation of a Novel Auto Segmentation Algorithm for Normal Structure Delineation in Radiation Treatment Planning

Mayo Clinic

NCT06200116

RECRUITING NA 200 participants

Acceptance and Commitment Therapy and Compassion-Based Virtual Group Therapy to Improve Psychological Wellbeing in Patients With Cancer

Mayo Clinic

NCT06246955

RECRUITING Phase 2 190 participants

A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

Children's Oncology Group

NCT06410209

RECRUITING 170 participants

Complications and Clinical Response in Cancer Patients Treated With Anti-VEGF-Related Therapies

M.D. Anderson Cancer Center

NCT05108519

RECRUITING Phase 3 160 participants

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Mayo Clinic

NCT06395441

RECRUITING NA 150 participants

Community-Based Exercise and Nutrition Training and Education Program for Cancer Survivors

Roswell Park Cancer Institute

NCT06565260

RECRUITING NA 147 participants

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Mayo Clinic

NCT06788886

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 22
Phase 3 12
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Solid Neoplasm Trial Landscape

177 indexed Malignant Solid Neoplasm studies · 94 recruiting (53%).

Phase mix: 14 late (III/IV) vs 46 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (42 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Solid Neoplasm?

PlainTrial tracks 177 US clinical trials for Malignant Solid Neoplasm, of which 94 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.