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Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia
NCT06001788 · View on ClinicalTrials.gov ↗
Study Summary
The safety, tolerability, and antileukemic response of ziftomenib in combination with standard of care treatments for patients with relapsed/refractory acute myeloid leukemia will be examined with the following agents: FLAG-IDA, low-dose cytarabine, and gilteritinib.
Conditions Studied
Interventions
- DRUG Fludarabine
- DRUG Cytarabine
- DRUG Idarubicin
- DRUG Gilteritinib
- DRUG Ziftomenib
Study Locations (20)
California
- USC Norris Comprehensive Cancer Center — Los Angeles
- UCLA Health - Bowyer Oncology Center — Los Angeles
- UC Irvine Health Chao Family Comprehensive Cancer Center — Orange
- University of California San Francisco — San Francisco
Illinois
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago
- Loyola University Medical Center — Maywood
- Simmons Cancer Institute — Springfield
Georgia
- Emory Healthcare - The Emory Clinic — Atlanta
- Georgia Cancer Center at Augusta University — Augusta
Michigan
- Karmanos Cancer Institute — Detroit
- Henry Ford Cancer Institute — Detroit
Arizona
- Banner MD Anderson Cancer Center — Gilbert
Colorado
- Colorado Blood Cancer Institute — Denver
Connecticut
- Smilow Cancer Hospital at Yale New Haven — New Haven
Iowa
- University of Iowa Hospitals & Clinics — Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2024-02-22 |
| Est. Completion | 2027-08 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06001788
The ClinicalTrials.gov registry entry for NCT06001788 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 171 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kura Oncology, which has 38 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Fludarabine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06001788 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Illinois, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06001788 about?
NCT06001788 is a clinical study titled "Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia". The safety, tolerability, and antileukemic response of ziftomenib in combination with standard of care treatments for patients with relapsed/refractory acute myeloid leukemia will be examined with the following agents: FLAG-IDA, low-dose cytarabine, and gilteritinib.
What is the current status of trial NCT06001788?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 171 participants. The study started on 2024-02-22. Estimated completion is 2027-08.
What conditions does trial NCT06001788 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia, Leukemia, Hematologic Malignancy, Leukemia, Myeloid, Acute, AML. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06001788?
The interventions under investigation include: Fludarabine (DRUG), Cytarabine (DRUG), Idarubicin (DRUG), Gilteritinib (DRUG), Ziftomenib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06001788?
This trial is sponsored by Kura Oncology, which has 38 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06001788 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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