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NCT02356653 · ClinicalTrials.gov registry record · Early Phase 1
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
A Early Phase 1 study of Leukemia and Immunodeficiencies, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT02356653: Recruiting Early Phase 1 study of Leukemia and Immunodeficiencies, sponsored by Children's Hospital of Philadelphia.
NCT02356653 is a Early Phase 1 study of Leukemia and Immunodeficiencies that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 100 participants, below the 486-participant average among 233 other Leukemia trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02356653, a Early Phase 1 study of Leukemia and Immunodeficiencies, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is indicated. These patients are not eligible for other Children's Hospital of Philadelphia IRB approved protocols that utilize CliniMACs technology for T depletion.
Primary Outcome
Number of participants who remain alive.
Conditions Studied
Interventions
- BIOLOGICAL Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs)
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2013-12 |
| Est. Completion | 2030-01 |
| Phase | Early Phase 1 |
What NCT02356653 shows while recruiting
NCT02356653 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 486-participant average among 233 other Leukemia trials with a reported enrollment target (79% lower).
The record links to 5 conditions, with Leukemia appearing as the primary indexed condition, and to 1 intervention - of which Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs) is the first listed.
NCT02356653 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02356653 about?
NCT02356653 is a clinical study titled "Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC". The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is ind...
What is the current status of trial NCT02356653?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 100 participants. The study started on 2013-12. Estimated completion is 2030-01.
What conditions does trial NCT02356653 study?
This clinical trial studies the following conditions: Leukemia, Immunodeficiencies, Inborn Errors of Metabolism, Bone Marrow Failure Syndromes, Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome.
What interventions are being tested in trial NCT02356653?
The interventions under investigation include: Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs) (BIOLOGICAL).
Who is sponsoring clinical trial NCT02356653?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02356653 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02356653's enrollment target sits among peer trials
100 59th of 233 higher than 170 of 233 other Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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