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ClinicalTrials.gov 30 recruiting now official registry

Ischemic Stroke clinical trials

30 of 67 indexed Ischemic Stroke trials are currently recruiting.

67 US clinical trials · 30 currently recruiting

Ischemic Stroke is the subject of 67 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 4 of these trials.

The research picture

Ischemic Stroke has 67 registered US clinical trials, 30 of them open to new participants right now, about 45% of the total.

30
recruiting participants now
45%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: Johns Hopkins University
Phase 110Phase 29Phase 43

Active & Recent Trials

67 total, page 1 of 2

RECRUITING 60,000 participants

Stroke Recovery Initiative - Registry for Stroke Research Studies

University of California, San Francisco

NCT03318432

RECRUITING 8,000 participants

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Massachusetts General Hospital

NCT04916210

RECRUITING 3,000 participants

Transitions of Care for Stroke Patients

Kiwon Lee MD

NCT06011720

RECRUITING NA 1,600 participants

StrokeNet Thrombectomy Endovascular Platform

Medical University of South Carolina

NCT06289985

RECRUITING 900 participants

Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders

Cedars-Sinai Medical Center

NCT02910180

RECRUITING NA 842 participants

CTSN Embolic Protection Trial

Icahn School of Medicine at Mount Sinai

NCT06027788

RECRUITING Phase 2 728 participants

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

DiaMedica Therapeutics

NCT05065216

RECRUITING NA 584 participants

Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe

Raul Nogueira

NCT05983757

RECRUITING 512 participants

Augmented Renal Clearance in Neurocritical Care

University of Alberta

NCT07410624

RECRUITING NA 360 participants

The Recovery in Stroke Using PAP Study

Yale University

NCT04130503

RECRUITING 350 participants

Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke

University of Virginia

NCT06292117

RECRUITING Phase 2 300 participants

Strategy for Improving Stroke Treatment Response

Translational Sciences

NCT05948566

RECRUITING 250 participants

Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

University of California, Los Angeles

NCT05518305

RECRUITING Phase 2 200 participants

Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke

Yale University

NCT04760717

RECRUITING 150 participants

Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

Johns Hopkins University

NCT05556395

RECRUITING NA 150 participants

Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors

Massachusetts General Hospital

NCT07414732

RECRUITING Phase 2 132 participants

Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial

ProMedica Health System

NCT06949228

RECRUITING NA 122 participants

EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

BrainQ Technologies

NCT06386874

RECRUITING NA 80 participants

Personalized Transcranial Direct Current Stimulation in Stroke Recovery

The Methodist Hospital Research Institute

NCT06286800

RECRUITING NA 72 participants

External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients

Johns Hopkins University

NCT06899711

RECRUITING NA 70 participants

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

University of Pennsylvania

NCT04897334

RECRUITING NA 70 participants

K01 Impacts of Lingual Endurance Exercise

University of Cincinnati

NCT06072924

RECRUITING Phase 1 60 participants

Verapamil for Neuroprotection in Stroke

Global Neurosciences Institute

NCT03347786

RECRUITING 50 participants

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Johns Hopkins University

NCT05703386

RECRUITING 45 participants

Post-Stroke Sensory Reweighting on Walking and Balance Outcomes

University of Cincinnati

NCT06727097

RECRUITING NA 42 participants

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke

Baylor Research Institute

NCT04534556

RECRUITING 40 participants

OsciPulse D-dimer Pilot Trial

University of Pennsylvania

NCT06477016

RECRUITING NA 20 participants

A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

Mayo Clinic

NCT07291024

RECRUITING Phase 1 20 participants

Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

Johns Hopkins University

NCT07053917

RECRUITING NA 15 participants

Virtual Reality Based Rehabilitation After Ischemic Stroke

Stony Brook University

NCT06401564

ACTIVE NOT RECRUITING NA 6,573 participants

Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

AtriCure

NCT05478304

ACTIVE NOT RECRUITING NA 3,062 participants

Sleep for Stroke Management and Recovery Trial

University of Michigan

NCT03812653

ACTIVE NOT RECRUITING 1,500 participants

A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites

University of Cincinnati

NCT00642213

ACTIVE NOT RECRUITING NA 168 participants

Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever

Rapid Medical

NCT05152524

ACTIVE NOT RECRUITING 114 participants

Symptomatic Carotid Outcomes Registry

University of Maryland, Baltimore

NCT05300737

ACTIVE NOT RECRUITING 72 participants

Florida Cerebrovascular Disease Biorepository and Genomics Center

Mayo Clinic

NCT05491980

ACTIVE NOT RECRUITING 50 participants

VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home

MicroTransponder

NCT05691023

ACTIVE NOT RECRUITING Phase 1 30 participants

A Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS)

Gary Steinberg, MD, PhD

NCT04631406

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Memantine for Enhanced Stroke Recovery

University of Utah

NCT02144584

ACTIVE NOT RECRUITING Phase 1 16 participants

A Study of NCS-01 in Patients With Acute Ischemic Stroke

NC Medial Research

NCT03915431

ACTIVE NOT RECRUITING NA 6 participants

Addressing Sleep Apnea Post-Stroke/TIA

VA Office of Research and Development

NCT04322162

COMPLETED 1,877 participants

Patient-centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research

Duke University

NCT02146274

COMPLETED Phase 4 1,500 participants

Quality Improvement in Stroke Prevention (QUISP)

University of California, San Francisco

NCT00328640

COMPLETED Phase 4 630 participants

Patent Foramen Ovale in Cryptogenic Stroke Study

Columbia University

NCT00697151

COMPLETED NA 552 participants

Discharge Educational Strategies for Reduction of Vascular Events

NYU Langone Health

NCT01836354

COMPLETED 400 participants

Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

Penumbra

NCT04693767

COMPLETED NA 300 participants

The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

Mercy Health Ohio

NCT03805308

COMPLETED NA 160 participants

Treatment With Intent to Generate Endovascular Reperfusion

Rapid Medical

NCT03474549

COMPLETED Phase 4 108 participants

Assess the Penumbra System in the Treatment of Acute Stroke

Penumbra

NCT01429350

COMPLETED NA 100 participants

The Efficacy of a Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Subacute Ischemic Stroke Patients - a Pivotal Study (THE "EMAGINE" STUDY)

BrainQ Technologies

NCT05044507

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 9
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Ischemic Stroke Trial Landscape

67 indexed Ischemic Stroke studies · 30 recruiting (45%).

Phase mix: 3 late (III/IV) vs 19 early (I/II).

Top sponsor: Johns Hopkins University (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Ischemic Stroke?

PlainTrial tracks 67 US clinical trials for Ischemic Stroke, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Ischemic Stroke?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.