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2026 data Public-data reference. official source

Alcoholism

Open-data reference.

66 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING 10,000 participants

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

National Institute on Drug Abuse (NIDA)

NCT06676059

RECRUITING 1,000 participants

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02108080

RECRUITING NA 400 participants

Behavioral and Functional Task Development, Implementation, and Testing

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02108054

RECRUITING 240 participants

Alcohol and the Social Brain: an Alcohol-Administration Hyperscanning Study

University of Illinois at Urbana-Champaign

NCT06687525

RECRUITING NA 200 participants

Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

University of Illinois at Urbana-Champaign

NCT07125534

RECRUITING NA 195 participants

CRP and S&A for Inpatient Veterans

VA Office of Research and Development

NCT05054738

RECRUITING NA 186 participants

Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)

Brainsway

NCT07216872

RECRUITING NA 130 participants

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Emory University

NCT02604277

RECRUITING Phase 4 60 participants

Naltrexone in AUD Reward Drinkers

University of Pennsylvania

NCT05028062

RECRUITING Phase 2 60 participants

Ketamine Alcohol (in Treatment-Resistant Depression)

Mark Niciu

NCT02122562

RECRUITING NA 40 participants

Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

VA Palo Alto Health Care System

NCT06415721

ACTIVE NOT RECRUITING NA 800 participants

Chicago Social Drinking Project

University of Chicago

NCT00961792

ACTIVE NOT RECRUITING Early Phase 1 782 participants

Behavioral Alcohol Responses (BAR) Study

Carnegie Mellon University

NCT03467191

ACTIVE NOT RECRUITING NA 234 participants

Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking With Peer Phone Support

VA Office of Research and Development

NCT05473598

ACTIVE NOT RECRUITING NA 135 participants

Telehealth Treatment for Alcohol Use Disorder

Ria Health

NCT05747703

ACTIVE NOT RECRUITING Phase 2 50 participants

Ibudilast for Treating Alcohol Use Disorder

University of Pennsylvania

NCT05414240

COMPLETED NA 1,767 participants

Ultra-brief Intervention for Problem Drinkers

Centre for Addiction and Mental Health

NCT00688584

COMPLETED Phase 3 1,375 participants

COMBINE (Acamprosate/Naltrexone)

University of North Carolina, Chapel Hill

NCT00006206

COMPLETED 1,194 participants

The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00001675

COMPLETED 485 participants

Acamprosate: Genes Associated With Response

Mayo Clinic

NCT00662571

COMPLETED Phase 2 360 participants

Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00027079

COMPLETED Phase 2 320 participants

A Randomized, Double-blind Placebo-Controlled Pharmacogenetic Study of Topiramate in European-American Heavy Drinkers

University of Pennsylvania

NCT02371889

COMPLETED NA 319 participants

Integrated Stepped Care for Unhealthy Alcohol Use in HIV

Yale University

NCT01410123

COMPLETED Phase 4 302 participants

Managing Alcoholism in People Who Do Not Respond to Naltrexone

University of Pennsylvania

NCT00115037

COMPLETED Phase 2 208 participants

Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1

University of Pennsylvania

NCT00142844

COMPLETED Phase 2 198 participants

Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)

Yale University

NCT00000451

COMPLETED Phase 4 180 participants

Naltrexone, Craving, and Drinking

Brown University

NCT00006203

COMPLETED NA 173 participants

Individualized Assessment and Treatment for Alcoholism II

UConn Health

NCT03233802

COMPLETED Phase 2 170 participants

Topiramate for Alcohol and Cocaine Dependence

Kyle Kampman

NCT00167245

COMPLETED Phase 2 168 participants

Integrated Alcohol Disorder and PTSD Treatment

VA Office of Research and Development

NCT01601067

COMPLETED NA 164 participants

Adaptive Interventions for Problem Drinkers

Northwell Health

NCT02511808

COMPLETED Phase 4 160 participants

Post-Treatment Effects of Naltrexone

Indiana University

NCT00006449

COMPLETED Phase 2 150 participants

Gabapentin Treatment of Alcohol Dependence

The Scripps Research Institute

NCT00391716

COMPLETED Phase 4 140 participants

Naltrexone for Heavy Drinking in Young Adults

Yale University

NCT00568958

COMPLETED Phase 2 136 participants

Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients

Yale University

NCT00342563

COMPLETED Phase 4 134 participants

Sertraline Pharmacotherapy for Alcoholism Subtypes

UConn Health

NCT00368550

COMPLETED 120 participants

Chronic Alcohol and Brain Stress Circuit Response

Yale University

NCT01031264

COMPLETED Phase 4 106 participants

Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00006204

COMPLETED Phase 2 103 participants

Mifepristone Treatment of Alcohol Use Disorder

The Scripps Research Institute

NCT02179749

COMPLETED 101 participants

Imaging Cannabinoid CB1 Receptors in Alcohol Dependence

National Institute of Mental Health (NIMH)

NCT00816439

COMPLETED Phase 4 90 participants

Naltrexone Treatment of Alcohol Abuse in Schizophrenia

State University of New York - Upstate Medical University

NCT00145847

COMPLETED Early Phase 1 88 participants

The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD

University of California, San Francis

NCT02469259

COMPLETED Phase 2 88 participants

A Study of LY2940094 in Participants With Alcohol Dependency

BlackThorn Therapeutics

NCT01798303

COMPLETED Phase 1 79 participants

Matching Genotypes and Serotonergic Medications for Alcoholism

Brown University

NCT01113164

COMPLETED Phase 3 75 participants

Aripiprazole for Bipolar Disorder and Alcohol Use Disorder

University of Texas Southwestern Medical Center

NCT02918370

COMPLETED NA 73 participants

GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

Yale University

NCT00611767

COMPLETED Phase 1 70 participants

Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment

University of Wisconsin, Madison

NCT02966340

COMPLETED 70 participants

The Stress-Hormone System in Alcohol-Dependent Subjects

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00536146

COMPLETED Early Phase 1 70 participants

The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00667771

COMPLETED Phase 2 66 participants

Effect of LY686017 on Alcohol Craving

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00310427

COMPLETED 62 participants

Neural Substrates of Approach-Avoidance Conflict

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02119624

COMPLETED Phase 3 61 participants

Quetiapine Fumarate (Seroquel) for the Treatment of Alcohol Dependence.

University of Pennsylvania

NCT00124059

COMPLETED Phase 4 57 participants

Naltrexone for Relapse Prevention

UConn Health

NCT00000442

COMPLETED Phase 1 46 participants

N-acetylcysteine in Alcohol Dependence

Minneapolis Veterans Affairs Medical Center

NCT00568087

COMPLETED NA 40 participants

Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects

UConn Health

NCT00802321

COMPLETED Phase 4 40 participants

Zonisamide vs. Placebo in the Treatment of Alcohol Dependence

UConn Health

NCT00595556

COMPLETED Phase 4 40 participants

The Effects of Levetiracetam on Alcohol Dependent Subjects

Boston University

NCT00325182

COMPLETED Phase 2 39 participants

Baclofen for Treating Anxiety and Alcoholism

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT01751386

COMPLETED NA 35 participants

EMPOWER AUD Pivotal Trial

Theranova, L.L.C.

NCT05948605

COMPLETED 35 participants

Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study

National Institute on Drug Abuse (NIDA)

NCT03152760

COMPLETED Phase 1 27 participants

Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

Northwell Health

NCT02885311

COMPLETED Phase 1 22 participants

Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence

Virginia Commonwealth University

NCT02120365

COMPLETED Phase 1 14 participants

A Novel Compound for Alcoholism Treatment

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02039349

COMPLETED 7 participants

Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound

Northwell Health

NCT01208311

COMPLETED Phase 1 1 participants

GSK1521498 Alcohol Interaction Study

GlaxoSmithKline

NCT01366573

COMPLETED Phase 2

Ondansetron Treatment for Alcoholism

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00000443

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 15
Phase 3 3
Phase 4 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcoholism Trial Landscape

ClinicalTrials.gov lists 66 US studies indexed under Alcoholism, and 11 of those are currently open to recruitment — roughly 17% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Alcoholism shows 14 late-stage studies (Phase 3 and Phase 4 combined) alongside 25 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Alcoholism is led by National Institute on Alcohol Abuse and Alcoholism (NIAAA) with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 66 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcoholism?

PlainTrial tracks 66 US clinical trials for Alcoholism, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcoholism?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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