Penumbra

25 total trials 2 currently recruiting 19 completed

Penumbra sponsors 25 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 19 completed. 1 of these trials are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Ischemic Stroke, with 2 trials.

Trial Pipeline

25 total, page 1 of 1

RECRUITING

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

NCT06747117

RECRUITING

Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System

NCT04798261

ACTIVE NOT RECRUITING NA

BOLT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis

NCT05003843

COMPLETED NA

Comparison of Two Pulmonary Embolism Treatments

NCT05684796

COMPLETED NA

THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing

NCT05437055

COMPLETED

Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

NCT04693767

TERMINATED

LOTUS: Global Acute Stroke Study Utilizing Penumbra System

NCT04157270

COMPLETED

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System

NCT04144959

COMPLETED

Assessing the WAVE Extra Soft Coil in Intracranial Aneurysms and Comparing Imaging Modalities

NCT04106583

TERMINATED

PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase

NCT04178746

COMPLETED

Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteries

NCT03957473

COMPLETED

COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device

NCT03464565

COMPLETED NA

MIND: Artemis in the Removal of Intracerebral Hemorrhage

NCT03342664

COMPLETED NA

Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism

NCT03218566

COMPLETED NA

Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil

NCT02729740

TERMINATED

CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Coil 400

NCT02122133

COMPLETED NA

Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery

NCT02085551

COMPLETED

A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial

NCT01092819

COMPLETED NA

The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms

NCT01636453

COMPLETED Phase 4

Assess the Penumbra System in the Treatment of Acute Stroke

NCT01429350

COMPLETED NA

A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke

NCT01584609

COMPLETED NA

Study of the Penumbra Coil 400 System to Treat Aneurysm

NCT01465841

COMPLETED NA

Imaging Guided Patient Selection for Interventional Revascularization Therapy

NCT00963989

COMPLETED

Penumbra Imaging Collaborative Study (PICS)

NCT00785161

COMPLETED Phase 2

Study to Assess the Safety and Effectiveness of the Penumbra System

NCT00334061

What the Pipeline for Penumbra Shows

According to the ClinicalTrials.gov registry, Penumbra is linked to 25 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 19 are already marked complete, representing roughly 76% of the total.

The phase mix for Penumbra reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 1 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Penumbra is Ischemic Stroke with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.