Penumbra
Penumbra sponsors 25 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 19 completed. 1 of these trials are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Ischemic Stroke, with 2 trials.
Trial Pipeline
25 total, page 1 of 1
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)
NCT06747117
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
NCT04798261
BOLT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
NCT05003843
Comparison of Two Pulmonary Embolism Treatments
NCT05684796
THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing
NCT05437055
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
NCT04693767
LOTUS: Global Acute Stroke Study Utilizing Penumbra System
NCT04157270
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System
NCT04144959
Assessing the WAVE Extra Soft Coil in Intracranial Aneurysms and Comparing Imaging Modalities
NCT04106583
PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase
NCT04178746
Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteries
NCT03957473
COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device
NCT03464565
MIND: Artemis in the Removal of Intracerebral Hemorrhage
NCT03342664
Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
NCT03218566
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
NCT02729740
CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Coil 400
NCT02122133
Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery
NCT02085551
A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial
NCT01092819
The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms
NCT01636453
Assess the Penumbra System in the Treatment of Acute Stroke
NCT01429350
A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke
NCT01584609
Study of the Penumbra Coil 400 System to Treat Aneurysm
NCT01465841
Imaging Guided Patient Selection for Interventional Revascularization Therapy
NCT00963989
Penumbra Imaging Collaborative Study (PICS)
NCT00785161
Study to Assess the Safety and Effectiveness of the Penumbra System
NCT00334061
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 4 | 1 |
What the Pipeline for Penumbra Shows
According to the ClinicalTrials.gov registry, Penumbra is linked to 25 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 19 are already marked complete, representing roughly 76% of the total.
The phase mix for Penumbra reports 1 late-stage studies (Phase 3 and Phase 4 combined) and 1 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Penumbra is Ischemic Stroke with 2 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.