Penumbra
Open enrollment across a mixed-phase pipeline
According to ClinicalTrials.gov-derived indexes, Penumbra sits in the top decile of US sponsors by registered trial count (#626 of 15,742 sponsors by registered trial count).
Penumbra: 25 sponsored US clinical trials, 2 recruiting.
Penumbra sponsors 25 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 19 completed. 1 of these trials are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Ischemic Stroke, with 2 trials.
Top-decile sponsor footprint
Penumbra ranks in the top decile of sponsors by registered trial count (#626 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.
Trial completion reliability score
19 of 22 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.
Open and recent trials
25 total, page 1 of 1
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)
NCT06747117
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
NCT04798261
BOLT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
NCT05003843
Comparison of Two Pulmonary Embolism Treatments
NCT05684796
THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing
NCT05437055
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
NCT04693767
LOTUS: Global Acute Stroke Study Utilizing Penumbra System
NCT04157270
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System
NCT04144959
Assessing the WAVE Extra Soft Coil in Intracranial Aneurysms and Comparing Imaging Modalities
NCT04106583
PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase
NCT04178746
Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteries
NCT03957473
COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device
NCT03464565
MIND: Artemis in the Removal of Intracerebral Hemorrhage
NCT03342664
Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
NCT03218566
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
NCT02729740
CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Coil 400
NCT02122133
Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery
NCT02085551
A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial
NCT01092819
The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms
NCT01636453
Assess the Penumbra System in the Treatment of Acute Stroke
NCT01429350
A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke
NCT01584609
Study of the Penumbra Coil 400 System to Treat Aneurysm
NCT01465841
Imaging Guided Patient Selection for Interventional Revascularization Therapy
NCT00963989
Penumbra Imaging Collaborative Study (PICS)
NCT00785161
Study to Assess the Safety and Effectiveness of the Penumbra System
NCT00334061
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 4 | 1 |
What is open in the Penumbra pipeline
2 recruiting of 25 indexed (8% open); 19 completed (76%).
Phase mix: 1 late (III/IV) vs 1 early (I/II) (balanced across stages).
Top condition: Ischemic Stroke (2 trials), 9 others listed.
How open-pipeline share is computed
Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.
Penumbra: open-pipeline peers nationwide
Peers matched on 25 registered trials and 8% open enrollment, not the therapeutic-area sidebar.
Penumbra sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.
Sponsors near 25 trials (± recruiting share)
- Arcus Biosciences · 25 trials · 12% recruiting
- Arcutis Biotherapeutics · 25 trials · 8% recruiting
- Ardelyx · 25 trials · 12% recruiting
- Drexel University College of Medicine · 25 trials · 0% recruiting
Sponsors near 8% open enrollment (± trial volume)
- Medtronic Endovascular · 8% recruiting · 25 trials
- Novartis Pharmaceuticals · 8% recruiting · 1,375 trials
- SK Life Science · 8% recruiting · 25 trials
- Syndax Pharmaceuticals · 8% recruiting · 25 trials
Related
What to do with this Penumbra page
25 registered trials is a research-attention snapshot, not an endorsement of Penumbra or any single study.
- 2 of Penumbra's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
- Ischemic Stroke is the condition Penumbra studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Ischemic Stroke trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Penumbra pipeline card: 25 registered trials from official public datasets.Report a data error.