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RECRUITING Phase 2

Strategy for Improving Stroke Treatment Response

NCT05948566 · View on ClinicalTrials.gov ↗

Study Summary

SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.

Conditions Studied

Interventions

  • BIOLOGICAL TS23

Study Locations (20)

California

  • UCSD Health La Jolla — La Jolla
  • Kaiser Permanente Los Angeles — Los Angeles
  • Sutter Medical Center — Sacramento
  • UCSD Medical Center- Hillcrest Hospital — San Diego

Arizona

  • Banner University Medical Center — Phoenix
  • Mayo Clinic Phoenix — Phoenix
  • Banner University Medical Center - Tucson — Tucson

Connecticut

  • Hartford Hospital — Hartford
  • Yale New Haven Hospital — New Haven

Florida

  • UF Health Shands Hospital — Gainesville
  • Jackson Memorial Hospital — Miami

Kentucky

  • Baptist Healthcare System, Inc. — Lexington
  • University of Louisville Hospital — Louisville

Massachusetts

  • Brigham and Women's Hospital — Boston
  • Massachusetts General Hospital — Boston

Alabama

  • University of Alabama Hospital — Birmingham

Delaware

  • Christiana Hospital — Newark

Trial Details

FieldValue
Enrollment Target 300 participants
Start Date 2024-03-18
Est. Completion 2027-12
Phase Phase 2

Sponsor

Translational Sciences

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05948566

The ClinicalTrials.gov registry entry for NCT05948566 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Translational Sciences, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ischemic Stroke appearing as the primary indexed condition, and to 1 intervention — of which TS23 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05948566 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Arizona, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05948566 about?

NCT05948566 is a clinical study titled "Strategy for Improving Stroke Treatment Response". SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.

What is the current status of trial NCT05948566?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 300 participants. The study started on 2024-03-18. Estimated completion is 2027-12.

What conditions does trial NCT05948566 study?

This clinical trial studies the following conditions: Ischemic Stroke. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05948566?

The interventions under investigation include: TS23 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05948566?

This trial is sponsored by Translational Sciences, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05948566 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial