Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05556395 · ClinicalTrials.gov registry record
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
A clinical trial of Ischemic Stroke, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT05556395: Recruiting study of Ischemic Stroke, sponsored by Johns Hopkins University.
NCT05556395 is a study of Ischemic Stroke that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 150 participants, below the 1,461-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05556395, a study of Ischemic Stroke, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.
Primary Outcome
Serial telephone-based cognitive assessments will be performed to detect cognitive changes (cognitive decline).
Conditions Studied
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2022-04-01 |
| Est. Completion | 2027-04-01 |
What NCT05556395 shows while recruiting
NCT05556395 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 1,461-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Ischemic Stroke appearing as the primary indexed condition, and to 0 interventions.
NCT05556395 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05556395 about?
NCT05556395 is a clinical study titled "Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline". The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the ri...
What is the current status of trial NCT05556395?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2022-04-01. Estimated completion is 2027-04-01.
What conditions does trial NCT05556395 study?
This clinical trial studies the following conditions: Ischemic Stroke.
Who is sponsoring clinical trial NCT05556395?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05556395 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ischemic Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05556395's enrollment target sits among peer trials
150 26th of 66 higher than 40 of 66 other Ischemic Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Ischemic Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke
RECRUITING · NA
-
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
RECRUITING
-
Transitions of Care for Stroke Patients
RECRUITING
-
Personalized Transcranial Direct Current Stimulation in Stroke Recovery
RECRUITING · NA
-
Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe
RECRUITING · NA
-
Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00412594 · 150 participants · Phase 2
Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia
- NCT01484730 · 150 participants
A Pilot Study to Evaluate Multi-Spectral and Laser Speckle Imaging and Multiphoton Microscopy During Vascular Occlusion
- NCT01985919 · 150 participants
Protocol for Facilitating the Acquisition of Research Bone Marrow and Blood Samples
- NCT02016248 · 150 participants · NA
SBRT Boost for Unfavorable Prostate Cancer'
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI