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NCT06949228 · ClinicalTrials.gov registry record · Phase 2

Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial

A Phase 2 study of Ischemic Stroke and Acute Disease, sponsored by ProMedica Health System.

Recruiting
Registry status
Phase 2
Development phase
132
Enrollment target
1
Study location

NCT06949228 is a Phase 2 study of Ischemic Stroke and Acute Disease that is actively recruiting participants, run by ProMedica Health System. The registered enrollment target is 132 participants, below the 1,462-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06949228, a Phase 2 study of Ischemic Stroke and Acute Disease, is actively recruiting participants, sponsored by ProMedica Health System.

RECRUITING
Registry status
Phase 2
Development phase
132 participants
Enrollment target
1
Study location

Study Summary

The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2) who achieve a reperfusion grade of Modified Treatment in Cerebral Ischemia Scale (mTICI) 2b or higher post-mechanical thrombectomy using Food and Drug Administration (FDA) approved devices.

Conditions Studied

Ischemic Stroke Acute Disease

Interventions

  • DRUG tenecteplase

Study Locations (1)

Ohio

  • ProMedica Toledo Hospital - Toledo

Trial Details

FieldValue
Enrollment Target 132 participants
Start Date 2025-07-30
Est. Completion 2028-05-30
Phase Phase 2

Sponsor

ProMedica Health System

12 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06949228

The ClinicalTrials.gov registry entry for NCT06949228 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 132 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,462-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (91% lower). The listed sponsor is ProMedica Health System, which has 12 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Ischemic Stroke appearing as the primary indexed condition, and to 1 intervention - of which tenecteplase is the first listed.

NCT06949228 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT06949228 about?

NCT06949228 is a clinical study titled "Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial". The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2) ...

What is the current status of trial NCT06949228?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 132 participants. The study started on 2025-07-30. Estimated completion is 2028-05-30.

What conditions does trial NCT06949228 study?

This clinical trial studies the following conditions: Ischemic Stroke, Acute Disease.

What interventions are being tested in trial NCT06949228?

The interventions under investigation include: tenecteplase (DRUG).

Who is sponsoring clinical trial NCT06949228?

This trial is sponsored by ProMedica Health System, which has 12 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06949228 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.