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NCT06949228 · ClinicalTrials.gov registry record · Phase 2
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
A Phase 2 study of Ischemic Stroke and Acute Disease, sponsored by ProMedica Health System.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 132
- Enrollment target
- 1
- Study location
NCT06949228: Recruiting Phase 2 study of Ischemic Stroke and Acute Disease, sponsored by ProMedica Health System.
NCT06949228 is a Phase 2 study of Ischemic Stroke and Acute Disease that is actively recruiting participants, run by ProMedica Health System. The registered enrollment target is 132 participants, below the 1,462-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06949228, a Phase 2 study of Ischemic Stroke and Acute Disease, is actively recruiting participants, sponsored by ProMedica Health System.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 132 participants
- Enrollment target
- 1
- Study location
Study Summary
The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2) who achieve a reperfusion grade of Modified Treatment in Cerebral Ischemia Scale (mTICI) 2b or higher post-mechanical thrombectomy using Food and Drug Administration (FDA) approved devices.
Primary Outcome
Proportion of patients with Modified Rankin Scale (mRS) 0-1 at 90-days. The mRS is the standard tool to assess neurological outcome in trials with acute severe brain disease. The scale runs from 0-6, running from perfect health without symptoms (= 0) to death (= 6).
Conditions Studied
Interventions
- DRUG tenecteplase
Study Locations (1)
Ohio
- ProMedica Toledo Hospital - Toledo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 132 participants |
| Start Date | 2025-07-30 |
| Est. Completion | 2028-05-30 |
| Phase | Phase 2 |
What NCT06949228 shows while recruiting
NCT06949228 is an interventional study that assigns participants to a tested intervention. The registered 132 participants enrollment target is mid-sized for trials with a published cap, below the 1,462-participant average among 66 other Ischemic Stroke trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Ischemic Stroke appearing as the primary indexed condition, and to 1 intervention - of which tenecteplase is the first listed.
NCT06949228 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06949228 about?
NCT06949228 is a clinical study titled "Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial". The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2) ...
What is the current status of trial NCT06949228?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 132 participants. The study started on 2025-07-30. Estimated completion is 2028-05-30.
What conditions does trial NCT06949228 study?
This clinical trial studies the following conditions: Ischemic Stroke, Acute Disease.
What interventions are being tested in trial NCT06949228?
The interventions under investigation include: tenecteplase (DRUG).
Who is sponsoring clinical trial NCT06949228?
This trial is sponsored by ProMedica Health System, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06949228 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ischemic Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06949228's enrollment target sits among peer trials
132 28th of 66 higher than 39 of 66 other Ischemic Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Ischemic Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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