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Hypertension: full-pipeline trial registry
152 of 472 indexed Hypertension trials are currently recruiting.
Corpus placement: #8 of 28,707 conditions by registered trial count.
472 US clinical trials · 152 currently recruiting · #8 of 28,707 conditions by registered trial count
Hypertension: 472 US clinical trials tracked, 152 recruiting.
Hypertension is the subject of 472 registered US clinical trials on ClinicalTrials.gov, 152 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 15 of these trials.
Enrollment posture brief
Registry condition hypertension
OPEN 152 | RECR 32% | LATE 65 | EARLY 64 | RANK #8 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Leukemia, Myeloid, Acute (32% recruiting · 31 trials)
Hypertension lists 152 open slots (32% of 472 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hypertension on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hypertension is recruiting below its size-band peers.
152 of 472 indexed trials (32.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Hypertension trials is spread across many organizations.
Johns Hopkins University accounts for 15 of 472 trials (3.2%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Hypertension enrolment sits around 168 participants.
Median target enrolment is 168 among the 471 trials that report a genuine target (sentinel values excluded). 170 of those (36.1%) plan for fewer than 100 participants.
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Hypertension research is mostly interventional.
407 interventional and 65 observational studies make up this index (86.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
472 total, page 8 of 10
Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nursing Intervention
Wayne State University
NCT01052220
Best Rest: Rest Time Before Blood Pressure Measurement Trial
Johns Hopkins University
NCT04031768
Nitric Oxide and the Autonomic Nervous System
Vanderbilt University
NCT00178919
Improving Outcomes for Hypertensive Children
Arkansas Children's Hospital Research Institute
NCT01485783
Interactive Spaced Education to Optimize Hypertension Management
VA Office of Research and Development
NCT00904007
An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension
Daiichi Sankyo
NCT00185068
A Pilot Study Comparing Nebivolol and Atenolol and Its Effects With Exercise in Patients With Mild to Moderate Hypertension
Mylan Bertek Pharmaceuticals
NCT00200421
Necklace-Shaped Sensor for Non-Invasive Remote Monitoring of Vitals
Baxter Healthcare Corporation
NCT02337790
Using Health Information Technology (HIT) to Improve Ambulatory Chronic Disease Care: Smart Device Substudy
University of Missouri-Columbia
NCT00802152
Racial Differences in Control of Blood Vessel Tone and Blood Flow
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001747
52-104 Week Off-therapy Second Extension to Study CSPP100A2365
Noden Pharma
NCT01420068
Dietary Approaches to Stop Hypertension for Diabetes
Johns Hopkins University
NCT04286555
REACH OUT: to Reduce High Blood Pressure in the Emergency Department
University of Michigan
NCT02301455
Effects of Omega-3 Fatty Acids on Markers of Inflammation
Stanford University
NCT01129050
307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects
AstraZeneca
NCT00255502
Intraoperative Blood Pressure and Cognitive Performance
Weill Medical College of Cornell University
NCT00827385
Randomized Trial to Evaluate the Effectiveness of Nurse Case Management
Johns Hopkins University
NCT00295256
Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
Emory University
NCT01041287
Atacand Dose Ranging in Hypertensive Pediatric Subjects 1 Year to Less Than 6 Years of Age
AstraZeneca
NCT00244621
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
University of Wisconsin, Madison
NCT01317329
Study of the Response of Human Small Blood Vessels
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001622
A Quality Improvement Process to Support Delivery of Cardiovascular Care in Community Mental Health Organizations
Johns Hopkins University
NCT04696653
Lifelight Non-Invasive Blood Pressure and Heart Rate Validation Study
Xim Limited
NCT06535152
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
University of Texas Southwestern Medical Center
NCT03354143
Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support
Amanda Shallcross
NCT06460272
Way to Health, Healthy Measures
University of Pennsylvania
NCT01282957
Improving Blood Pressure Control Among Food Insecure Hypertensive Adults
University of Florida
NCT05877898
The Effect of a Peroxisome Proliferator-activated Receptor (PPAR) Alpha Agonist on Cytochrome P450 (CYP) Monooxygenase Activity in Humans
Vanderbilt University
NCT00872599
Understanding the Exercise-Hypertension Paradox
VA Office of Research and Development
NCT02034422
Feasibility of Integrating Indirect Calorimetry (IC) Technology in Primary Care
Colorado Center for Chronic Care Innovations
NCT00750022
Pivotal Bioequivalence Study to Qualify Manufacturing Site Transfer for Prazosin Hydrochloride Capsules
Pfizer
NCT04967443
Evaluation of a Lifestyle Medicine Practice
Ohio University
NCT03739034
Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management
Cleveland Clinic Akron General
NCT05174078
Controlling Blood Pressure in Treatment Resistant Hypertension: A Pilot Study
Medical University of South Carolina
NCT02167464
Exercise in Pregnancy for Reduction of Blood Pressure in Obese Patients
Milton S. Hershey Medical Center
NCT01261884
Effects of Dark Chocolate on Insulin Sensitivity in People With High Blood Pressure
National Center for Complementary and Integrative Health (NCCIH)
NCT00099476
Activity Trackers for Improving BP
University of California, San Francisco
NCT03325426
Comorbidities And Reducing inEquitieS
Medstar Health Research Institute
NCT04836221
Walk Together: A Family-Based Intervention for Hypertension In African Americans
University of Texas Southwestern Medical Center
NCT05671302
The Penn Lifestyle Modification and Blood Pressure Study
University of Pennsylvania
NCT00328666
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
Daiichi Sankyo
NCT00185094
Improving Hypertension Control
Medical College of Wisconsin
NCT01910857
Cornell Translational Behavioral Science Research Consortium: Hypertension Qualitative Study
Weill Medical College of Cornell University
NCT00227175
Trial to Address Food Insecurity in Patients With Hypertension (SMART-FI)
Wake Forest University Health Sciences
NCT05800145
Antihypertensive Treatment in Acute Cerebral Hemorrhage
University of Minnesota
NCT00415610
Behavioral Economics to Improve Antihypertensive Therapy Adherence
Cedars-Sinai Medical Center
NCT04029883
Biomarker Guided Therapies in Stage A/B Heart Failure
VA Office of Research and Development
NCT02230891
A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch
The Cleveland Clinic
NCT03986281
Mindfulness Based Stress Reduction for High Blood Pressure
Kent State University
NCT00440596
Insights for Community Health
NYU Langone Health
NCT01681862
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 39 |
| Phase 2 | 25 |
| Phase 3 | 37 |
| Phase 4 | 28 |
Top Sponsors
Named interventions
Most-linked intervention names on Hypertension records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hypertension trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hypertension page
472 registered trials, 152 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 152 Hypertension trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Hypertension trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hypertension condition card totals 472 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.