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NCT03354143 · ClinicalTrials.gov registry record · Phase 2
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
A Phase 2 study of Hypertension, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 85
- Enrollment target
- 1
- Study location
NCT03354143: Completed Phase 2 study of Hypertension, sponsored by University of Texas Southwestern Medical Center.
NCT03354143 is a Phase 2 study of Hypertension that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 85 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03354143, a Phase 2 study of Hypertension, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 85 participants
- Enrollment target
- 1
- Study location
Study Summary
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase brain amyloid beta protein accumulation and affect memory and thinking ability in older adults. However, whether lowering blood pressure reduces brain amyloid beta protein and improves brain function is inconclusive. The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces brain amyloid beta protein accumulation and improves brain structure and function.
Primary Outcome
Changes (12 month timepoint minus baseline) in intracranial pulsatility will be measured with CINE phase-contrast MRI. We will use the velocity-encoded CINE PC MRI to measure intracranial pulsatility. Pulsatility measured in mm per cardiac cycle
Conditions Studied
Interventions
- OTHER Standard Care
- OTHER Intensive Treatment
Study Locations (1)
Texas
- UT Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2018-04-10 |
| Est. Completion | 2024-03-30 |
| Phase | Phase 2 |
What the finished NCT03354143 record still lists
NCT03354143 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Standard Care is the first listed.
NCT03354143 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT03354143 about?
NCT03354143 is a clinical study titled "Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)". The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hy...
What is the current status of trial NCT03354143?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 85 participants. The study started on 2018-04-10. Estimated completion is 2024-03-30.
What conditions does trial NCT03354143 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT03354143?
The interventions under investigation include: Standard Care (OTHER), Intensive Treatment (OTHER).
Who is sponsoring clinical trial NCT03354143?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03354143 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03354143's enrollment target sits among peer trials
85 313th of 470 higher than 156 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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