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NCT00178919 · ClinicalTrials.gov registry record · NA
Nitric Oxide and the Autonomic Nervous System
A NA study of Hypertension and Pure Autonomic Failure, sponsored by Vanderbilt University.
- Completed
- Registry status
- NA
- Development phase
- 112
- Enrollment target
- 1
- Study location
NCT00178919: Completed NA study of Hypertension and Pure Autonomic Failure, sponsored by Vanderbilt University.
NCT00178919 is a NA study of Hypertension and Pure Autonomic Failure that has completed, run by Vanderbilt University. The registered enrollment target is 112 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00178919, a NA study of Hypertension and Pure Autonomic Failure, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- NA
- Development phase
- 112 participants
- Enrollment target
- 1
- Study location
Study Summary
The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels. Nitric oxide (NO) is one of the most important of these metabolic factors. If the production of NO is slowed or stopped the amount of blood to the different parts of the body is decreased. There is increasing knowledge that NO mechanisms are impaired in a number of medical conditions. NO function is reduced in patients with risk factors for atherosclerosis (hardening of the arteries) such as hypercholesterolemia (patients with high cholesterol), or diabetes mellitus, and is also impaired in smokers. This NO "deficiency" is believed to contribute to the greater cardiovascular risk that marks these patient populations. This study is designed to examine if endothelial nitric oxide is an important control mechanism of blood pressure under normal conditions, and if impairment of nitric oxide contributes to hypertension.
Primary Outcome
L-NMMA (nitric oxide synthase inhibitor) was infused intravenously at different doses for 15 minutes each, after blocking the autonomic nervous system with trimethaphan. The change in systolic blood pressure at the end of the highest tolerated dose is the main outcome. Trimethaphan infused intravenously was used to produce transient blockade of the autonomic nervous system to allow for a full response to nitric oxide inhibition (in the absence of the baroreflex.
Conditions Studied
Interventions
- DRUG L-NMMA
- DRUG Trimethaphan
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 112 participants |
| Start Date | 2002-08 |
| Est. Completion | 2008-08 |
| Phase | NA |
What the finished NCT00178919 record still lists
NCT00178919 is an interventional study that assigns participants to a tested intervention. The registered 112 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which L-NMMA is the first listed.
NCT00178919 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00178919 about?
NCT00178919 is a clinical study titled "Nitric Oxide and the Autonomic Nervous System". The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels. Nitric oxide (NO) is one of the most important of these metabolic factors. If the production of NO is slowed or stopped the amount of bl...
What is the current status of trial NCT00178919?
This trial is currently completed. It is a NA study. The enrollment target is 112 participants. The study started on 2002-08. Estimated completion is 2008-08.
What conditions does trial NCT00178919 study?
This clinical trial studies the following conditions: Hypertension, Pure Autonomic Failure.
What interventions are being tested in trial NCT00178919?
The interventions under investigation include: L-NMMA (DRUG), Trimethaphan (DRUG).
Who is sponsoring clinical trial NCT00178919?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00178919 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00178919's enrollment target sits among peer trials
112 277th of 470 higher than 193 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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