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NCT00178919 · ClinicalTrials.gov registry record · NA
Nitric Oxide and the Autonomic Nervous System
A NA study of Hypertension and Pure Autonomic Failure, sponsored by Vanderbilt University.
- Completed
- Registry status
- NA
- Development phase
- 112
- Enrollment target
- 1
- Study location
NCT00178919 is a NA study of Hypertension and Pure Autonomic Failure that has completed, run by Vanderbilt University. The registered enrollment target is 112 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00178919, a NA study of Hypertension and Pure Autonomic Failure, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- NA
- Development phase
- 112 participants
- Enrollment target
- 1
- Study location
Study Summary
The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels. Nitric oxide (NO) is one of the most important of these metabolic factors. If the production of NO is slowed or stopped the amount of blood to the different parts of the body is decreased. There is increasing knowledge that NO mechanisms are impaired in a number of medical conditions. NO function is reduced in patients with risk factors for atherosclerosis (hardening of the arteries) such as hypercholesterolemia (patients with high cholesterol), or diabetes mellitus, and is also impaired in smokers. This NO "deficiency" is believed to contribute to the greater cardiovascular risk that marks these patient populations. This study is designed to examine if endothelial nitric oxide is an important control mechanism of blood pressure under normal conditions, and if impairment of nitric oxide contributes to hypertension.
Conditions Studied
Interventions
- DRUG L-NMMA
- DRUG Trimethaphan
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 112 participants |
| Start Date | 2002-08 |
| Est. Completion | 2008-08 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00178919
The ClinicalTrials.gov registry entry for NCT00178919 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 112 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower). The listed sponsor is Vanderbilt University, which has 430 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which L-NMMA is the first listed.
NCT00178919 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT00178919 about?
NCT00178919 is a clinical study titled "Nitric Oxide and the Autonomic Nervous System". The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels. Nitric oxide (NO) is one of the most important of these metabolic factors. If the production of NO is slowed or stopped the amount of bl...
What is the current status of trial NCT00178919?
This trial is currently completed. It is a NA study. The enrollment target is 112 participants. The study started on 2002-08. Estimated completion is 2008-08.
What conditions does trial NCT00178919 study?
This clinical trial studies the following conditions: Hypertension, Pure Autonomic Failure.
What interventions are being tested in trial NCT00178919?
The interventions under investigation include: L-NMMA (DRUG), Trimethaphan (DRUG).
Who is sponsoring clinical trial NCT00178919?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00178919 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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