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NCT00001622 · ClinicalTrials.gov registry record · Phase 1
Study of the Response of Human Small Blood Vessels
A Phase 1 study of Healthy and Hypertension, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- Completed
- Registry status
- Phase 1
- Development phase
- 87
- Enrollment target
- 1
- Study location
NCT00001622: Completed Phase 1 study of Healthy and Hypertension, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
NCT00001622 is a Phase 1 study of Healthy and Hypertension that has completed, run by National Heart, Lung, and Blood Institute (NHLBI). The registered enrollment target is 87 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001622, a Phase 1 study of Healthy and Hypertension, has completed, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 87 participants
- Enrollment target
- 1
- Study location
Study Summary
A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel. One of the substances produced involved in the control of blood vessel function is nitric oxide. Nitric oxide (NO) plays a role in the relaxation of blood vessels. Researchers have been interested in the function of the endothelium in patients with high blood pressure (essential hypertension) and patients with high cholesterol (hypercholesterolemia). After conducting studies on the endothelium and nitric oxide, researchers have found that the endothelium is indeed functioning abnormally in patients with high blood pressure and high cholesterol. In addition, researchers have determined that the dysfunction is a result of abnormalities in the nitric oxide (NO) system. In this study researchers plan to investigate the relationship between blood vessel responses in real-life settings versus laboratory settings in normal volunteers, patients with high blood pressure, and patients with high cholesterol.
Conditions Studied
Interventions
- PROCEDURE investigate the relationship between in vivo and in vitro vascular responses
Study Locations (1)
Maryland
- National Heart, Lung and Blood Institute (NHLBI) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 87 participants |
| Start Date | 1997-03 |
| Est. Completion | 2001-03 |
| Phase | Phase 1 |
What the finished NCT00001622 record still lists
NCT00001622 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 87 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (87% lower).
The record links to 3 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which investigate the relationship between in vivo and in vitro vascular responses is the first listed.
NCT00001622 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00001622 about?
NCT00001622 is a clinical study titled "Study of the Response of Human Small Blood Vessels". A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel. One of the substances produced involved in the control of blood vessel function is nitric oxide. Nitric oxide...
What is the current status of trial NCT00001622?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 87 participants. The study started on 1997-03. Estimated completion is 2001-03.
What conditions does trial NCT00001622 study?
This clinical trial studies the following conditions: Healthy, Hypertension, Hypercholesterolemia.
What interventions are being tested in trial NCT00001622?
The interventions under investigation include: investigate the relationship between in vivo and in vitro vascular responses (PROCEDURE).
Who is sponsoring clinical trial NCT00001622?
This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 501 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001622 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00001622's enrollment target sits among peer trials
87 261st of 1090 higher than 830 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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