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NCT00001622 · ClinicalTrials.gov registry record · Phase 1

Study of the Response of Human Small Blood Vessels

A Phase 1 study of Healthy and Hypertension, sponsored by National Heart, Lung, and Blood Institute (NHLBI).

Completed
Registry status
Phase 1
Development phase
87
Enrollment target
1
Study location

NCT00001622 is a Phase 1 study of Healthy and Hypertension that has completed, run by National Heart, Lung, and Blood Institute (NHLBI). The registered enrollment target is 87 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT00001622, a Phase 1 study of Healthy and Hypertension, has completed, sponsored by National Heart, Lung, and Blood Institute (NHLBI).

COMPLETED
Registry status
Phase 1
Development phase
87 participants
Enrollment target
1
Study location

Study Summary

A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel. One of the substances produced involved in the control of blood vessel function is nitric oxide. Nitric oxide (NO) plays a role in the relaxation of blood vessels. Researchers have been interested in the function of the endothelium in patients with high blood pressure (essential hypertension) and patients with high cholesterol (hypercholesterolemia). After conducting studies on the endothelium and nitric oxide, researchers have found that the endothelium is indeed functioning abnormally in patients with high blood pressure and high cholesterol. In addition, researchers have determined that the dysfunction is a result of abnormalities in the nitric oxide (NO) system. In this study researchers plan to investigate the relationship between blood vessel responses in real-life settings versus laboratory settings in normal volunteers, patients with high blood pressure, and patients with high cholesterol.

Conditions Studied

Healthy Hypertension Hypercholesterolemia

Interventions

  • PROCEDURE investigate the relationship between in vivo and in vitro vascular responses

Study Locations (1)

Maryland

  • National Heart, Lung and Blood Institute (NHLBI) - Bethesda

Trial Details

FieldValue
Enrollment Target 87 participants
Start Date 1997-03
Est. Completion 2001-03
Phase Phase 1

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

501 total trials

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What the Registry Record Tells You About NCT00001622

The ClinicalTrials.gov registry entry for NCT00001622 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 87 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (87% lower). The listed sponsor is National Heart, Lung, and Blood Institute (NHLBI), which has 501 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which investigate the relationship between in vivo and in vitro vascular responses is the first listed.

NCT00001622 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT00001622 about?

NCT00001622 is a clinical study titled "Study of the Response of Human Small Blood Vessels". A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel. One of the substances produced involved in the control of blood vessel function is nitric oxide. Nitric oxide...

What is the current status of trial NCT00001622?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 87 participants. The study started on 1997-03. Estimated completion is 2001-03.

What conditions does trial NCT00001622 study?

This clinical trial studies the following conditions: Healthy, Hypertension, Hypercholesterolemia.

What interventions are being tested in trial NCT00001622?

The interventions under investigation include: investigate the relationship between in vivo and in vitro vascular responses (PROCEDURE).

Who is sponsoring clinical trial NCT00001622?

This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 501 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00001622 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.