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Hypertension: full-pipeline trial registry
152 of 472 indexed Hypertension trials are currently recruiting.
Corpus placement: #8 of 28,707 conditions by registered trial count.
472 US clinical trials · 152 currently recruiting · #8 of 28,707 conditions by registered trial count
Hypertension: 472 US clinical trials tracked, 152 recruiting.
Hypertension is the subject of 472 registered US clinical trials on ClinicalTrials.gov, 152 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 15 of these trials.
Enrollment posture brief
Registry condition hypertension
OPEN 152 | RECR 32% | LATE 65 | EARLY 64 | RANK #8 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Leukemia, Myeloid, Acute (32% recruiting · 31 trials)
Hypertension lists 152 open slots (32% of 472 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hypertension on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hypertension is recruiting below its size-band peers.
152 of 472 indexed trials (32.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Hypertension trials is spread across many organizations.
Johns Hopkins University accounts for 15 of 472 trials (3.2%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Hypertension enrolment sits around 168 participants.
Median target enrolment is 168 among the 471 trials that report a genuine target (sentinel values excluded). 170 of those (36.1%) plan for fewer than 100 participants.
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Hypertension research is mostly interventional.
407 interventional and 65 observational studies make up this index (86.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
472 total, page 7 of 10
Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients
Massachusetts General Hospital
NCT02551640
Group Visits to Improve Hypertension Management
US Department of Veterans Affairs
NCT00129493
A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention
Case Western Reserve University
NCT03643705
Health Coach Program to Improve Chronic Disease Outcomes Following an Emergency Department Visit
Alameda County Medical Center
NCT02386540
Improving Blood Pressure in Colorado
Kaiser Permanente
NCT00520988
A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen
Mineralys Therapeutics
NCT05769608
A Randomized Trial of Changing Medication Adherence In Hypertensive African-American Patients
Weill Medical College of Cornell University
NCT00248872
A Study of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Stage I and Stage II Hypertension
Daiichi Sankyo
NCT00430638
Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women
National Heart, Lung, and Blood Institute (NHLBI)
NCT00666172
Mechanisms Underlying the Blood Pressure Lowering Effect of Sleep
Beth Israel Deaconess Medical Center
NCT03043963
Veterans Walk for Health Study
US Department of Veterans Affairs
NCT00123435
RCT of Effects of Device-guided Breathing on Ambulatory BP
Rutgers, The State University of New Jersey
NCT01184755
Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral
Johns Hopkins University
NCT05574699
A Clinical Study to Evaluate the Long-term Safety (12 Months) of the Combination of Aliskiren 300 mg and Hydrochlorothiazide 25 mg
Novartis
NCT00171405
Remote Monitoring and Social Support for Hypertension Management
University of Pennsylvania
NCT03416283
Can Group Visits Improve Outcomes of Veterans With Diabetes
US Department of Veterans Affairs
NCT00286741
DETECT and Retinal Outcomes in Hypertension
Emory University
NCT01815567
A ED-based Intervention to Improve Antihypertensive Adherence
Vanderbilt University
NCT02672787
Expanding Technology-Enabled Nurse Delivered Chronic Disease Care
Duke University
NCT05120544
Epidemiology of Hypertensive Emergency
Columbia University
NCT00005240
Medically Tailored Groceries and Food Resource Coaching
University of Texas Southwestern Medical Center
NCT06242808
An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age
Novartis Pharmaceuticals
NCT01151410
Patient Centered Health Technology Medication Adherence Program for African American Hypertensives
Medical University of South Carolina
NCT03454308
Smoking Study With Behavioral Therapy for Hypertensive Patients
UConn Health
NCT00879177
Federal Study of Adherence to Medications in the Elderly (FAME)
Walter Reed Army Medical Center
NCT00393419
Real-world Aliskiren Use in Diabetic Patients
Novartis
NCT01393860
Perioperative Blood Pressures and Chronic Hypertension
Yale University
NCT02136810
CONtrolling Disease Using Inexpensive IT - Hypertension in Diabetes
University of Massachusetts, Worcester
NCT01416766
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Renin Profiling in Selection of Initial Antihypertensive Drug
The Louis & Rachel Rudin Foundation
NCT00834600
Effect of a Secure Message Reminder on Hypertension Follow-up at an Integrated Health Care System
Kaiser Permanente
NCT01952119
Cognitive Dysfunction in Hypertensive Patients Having Spine Surgery
Columbia University
NCT01140854
Open-Label Extension Study of Patients Previously Enrolled in Study CIN-107-124
AstraZeneca
NCT05459688
Impact of Community Health Workers on Adherence to Therapy for Non-Communicable Chronic Disease in Chiapas, Mexico
Brigham and Women's Hospital
NCT02549495
Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension
University of Texas Southwestern Medical Center
NCT00353652
Veteran Preference For Group Visits and Its Effect on Hypertension Outcomes
US Department of Veterans Affairs
NCT00439816
A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
Ionis Pharmaceuticals
NCT04714320
Achieving Blood Pressure Control Together Study
Johns Hopkins University
NCT01902719
Treatment of Supine Hypertension in Autonomic Failure
Vanderbilt University
NCT00223717
Internet-based Diabetes Education and Case Management
US Department of Veterans Affairs
NCT00105898
Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians
Black Hills Center for American Indian Health
NCT00608387
Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia
University of Pittsburgh
NCT03749746
Radio Stories About Children's Healthy Eating and Exercise
University of Minnesota
NCT02139787
Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
Esperion Therapeutics
NCT02178098
Achieving Blood Pressure Control Through Enhanced Discharge
Wayne State University
NCT02069015
Take Charge of Your Diabetes
University of Pennsylvania
NCT01977495
ARMS: The Arm Rest and Support Study
Johns Hopkins University
NCT05372328
Salt Loading and Thiazide Intervention Study
University of Maryland, Baltimore
NCT00896389
Mechanisms and Therapeutic Effects of the Relaxation Response in Elderly Hypertensive Patients
Beth Israel Deaconess Medical Center
NCT00179543
Combined Behavioral and Pharmacological Intervention for Cardiovascular Risk Reduction in Diabetic Patients
Providence VA Medical Center
NCT00357955
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 39 |
| Phase 2 | 25 |
| Phase 3 | 37 |
| Phase 4 | 28 |
Top Sponsors
Named interventions
Most-linked intervention names on Hypertension records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hypertension trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hypertension page
472 registered trials, 152 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 152 Hypertension trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Hypertension trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hypertension condition card totals 472 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.