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ClinicalTrials.gov 15 recruiting now early-phase tilt

HIV/AIDS: early-phase trial registry

15 of 62 indexed HIV/AIDS trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #228 of 28,707 conditions by registered trial count.

62 US clinical trials · 15 currently recruiting · #228 of 28,707 conditions by registered trial count

HIV/AIDS: 62 US clinical trials tracked, 15 recruiting.

HIV/AIDS is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 7 of these trials.

Enrollment posture brief

Registry condition hivaids

OPEN 15 | RECR 24% | LATE 1 | EARLY 8 | RANK #228 | SPON 7

Nearest open-share peer: Myopia (24% recruiting · 91 trials)

Cognitive Decline58.1%Myelofibrosis46.8%Delirium38.1%Lymphoma, Non-Hodgkin25.8%HIV/AIDS (this)24%
Open-enrollment share among volume-matched conditions near HIV/AIDS

HIV/AIDS lists 15 open slots (24% of 62 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for HIV/AIDS on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. HIV/AIDS is recruiting below its size-band peers.

    15 of 62 indexed trials (24.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of HIV/AIDS trials is spread across many organizations.

    University of California, San Francisco accounts for 7 of 62 trials (11.3%). 38 distinct sponsors appear on at least one study for this condition label.

  3. Typical HIV/AIDS enrolment sits around 141 participants.

    Median target enrolment is 141 among the 62 trials that report a genuine target (sentinel values excluded). 25 of those (40.3%) plan for fewer than 100 participants.

  4. HIV/AIDS research is mostly interventional.

    53 interventional and 9 observational studies make up this index (85.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 16Phase 22Phase 31

Open and recent trials

62 total, page 1 of 2

RECRUITING 2,000,000 participants

Observational Pharmaco-Epidemiology Research & Analysis

Epividian

NCT03813862

RECRUITING NA 3,200 participants

MyPEEPS LITE Trial

Columbia University

NCT06741631

RECRUITING NA 1,500 participants

Improving the Organizational Social Context to Address Structural Racism and Discrimination

University of Pennsylvania

NCT06462807

RECRUITING NA 500 participants

MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM

Columbia University

NCT06741618

RECRUITING NA 420 participants

Community Health Workers And MHealth to ImProve Viral Suppression Plus (CHAMPS+)

Columbia University

NCT06472206

RECRUITING NA 418 participants

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

NCT03135886

RECRUITING NA 360 participants

Women SHINE: Addressing Syndemics and HIV Among Women Through Tech-Based Peer Engagement

University of California, San Diego

NCT05509959

RECRUITING Phase 3 340 participants

Optimizing Tobacco Use Treatment for PLWHA

University of Pennsylvania

NCT04176172

RECRUITING NA 250 participants

ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV

Massachusetts General Hospital

NCT06274632

RECRUITING NA 200 participants

A Mobile Gaming App to Improve Adherence to PrEP

Rhode Island Hospital

NCT05762705

RECRUITING NA 141 participants

Appalachian Partnership to Reduce Disparities (Aim 2)

Wake Forest University Health Sciences

NCT04378439

RECRUITING Phase 2 110 participants

An Integrated Intervention Using a Pill Ingestible Sensor System

University of California, Los Angeles

NCT06480578

RECRUITING NA 80 participants

An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS

University of Miami

NCT03738410

RECRUITING NA 60 participants

LinkPositively+ A Mobile Health App Delivered Intervention to Improve HIV Care Outcomes Among Black Women Affected by Mental Health and Violence

Guiding Right

NCT06458660

RECRUITING NA 40 participants

SCOPE Analytic Treatment Interruption Protocol

University of California, San Francisco

NCT04359186

ACTIVE NOT RECRUITING NA 1,928 participants

ResIlience-based Stigma REdUction Program ("Rise-up")

University of South Carolina

NCT05174936

ACTIVE NOT RECRUITING NA 200 participants

Intervention for Virologic Suppression in Youth

University of California, San Francisco

NCT05877729

ACTIVE NOT RECRUITING Phase 2 108 participants

Effects of Semaglutide in HIV-Associated Lipohypertrophy

Case Western Reserve University

NCT04019197

ACTIVE NOT RECRUITING Early Phase 1 100 participants

Impact of HIV-1 and Aging on Mucosal Vaccine Responses

VA Eastern Colorado Health Care System

NCT03729778

ACTIVE NOT RECRUITING NA 62 participants

Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA

Johns Hopkins University

NCT04298905

ACTIVE NOT RECRUITING NA 30 participants

Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana

University of Pennsylvania

NCT04488250

ACTIVE NOT RECRUITING Phase 1 11 participants

Combinatorial Therapy to Induce an HIV Remission

University of California, San Francisco

NCT04357821

COMPLETED 6,613 participants

HIV Jail POC-AgAB Testings

Montefiore Medical Center

NCT04296331

COMPLETED NA 791 participants

Theory-based HIV Disclosure Intervention for Parents

University of South Carolina

NCT04051177

COMPLETED NA 682 participants

PositiveLinks: mHealth for DC Cohort

George Washington University

NCT04998019

COMPLETED NA 579 participants

Effectiveness of Peer Navigation and Contingency Management on Retention in HIV Care

University of California, Los Angeles

NCT02310893

COMPLETED NA 500 participants

Behavioral Intervention to Enhance HIV Test/Treat

University of Connecticut

NCT01752777

COMPLETED NA 478 participants

Integrating HIV and Hepatitis C Screening in an Urban Emergency Department

New York City Health and Hospitals Corporation

NCT03252483

COMPLETED NA 451 participants

Leveraging mHealth and Peers to Engage African- Americans and Latinxs in HIV Care (LEAN)

Johns Hopkins University

NCT03934437

COMPLETED 412 participants

COVID-19 in Patients With HIV

University of Missouri-Columbia

NCT04333953

COMPLETED 334 participants

Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite

Harvard School of Public Health (HSPH)

NCT03279185

COMPLETED NA 306 participants

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

RAND

NCT03331978

COMPLETED NA 298 participants

A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention

Case Western Reserve University

NCT03643705

COMPLETED NA 288 participants

Duo Partnership Adherence Commitment Therapy

University of California, San Francisco

NCT02925949

COMPLETED 257 participants

MEMO-Medical Marijuana and Opioids Study

Albert Einstein College of Medicine

NCT03268551

COMPLETED NA 208 participants

ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction

University of Wisconsin, Madison

NCT03873129

COMPLETED NA 197 participants

CASA: Care and Support Access in HIV Disease

University of Maryland

NCT02136680

COMPLETED NA 196 participants

Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain

New York University

NCT03855111

COMPLETED NA 196 participants

Prevention and Risk: Treatment With a New Emphasis on Relationships

Hunter College of City University of New York

NCT03396367

COMPLETED NA 141 participants

Developing and Examining Evidenced-Based HIV Testing Messages

Virginia Commonwealth University

NCT03433053

COMPLETED NA 120 participants

Project RAP: Family-based HIV Prevention in the Juvenile Drug Court

University of California, San Francisco

NCT01403298

COMPLETED NA 100 participants

iSTEP - an mHealth Physical Activity and Diet Intervention for Persons With HIV

University of California, San Diego

NCT03123731

COMPLETED NA 100 participants

Linking High-Risk Jail Detainees to HIV Pre-Exposure Prophylaxis: PrEP-LINK

University of Arkansas

NCT04064567

COMPLETED 80 participants

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development

Hektoen Institute for Medical Research

NCT04077138

COMPLETED NA 71 participants

Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM

Florida State University

NCT04289116

COMPLETED NA 65 participants

PlusCare: Mobile Platform to Increase Linkage to Care in Adolescents Living With HIV/AIDS

Dimagi

NCT03758066

COMPLETED 50 participants

Assessment of Cognitive Functioning as it Relates to Risk for Suicide in Veterans With HIV/AIDS

VA Eastern Colorado Health Care System

NCT01749007

COMPLETED Phase 1 49 participants

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study

Hektoen Institute for Medical Research

NCT03652623

COMPLETED 46 participants

Development of a Couple-Based Mobile Health Intervention for Enhancing HIV Care Engagement Outcomes (N'Gage)

University of California, San Francisco

NCT03100643

COMPLETED Phase 1 41 participants

Body Compartment Pharmacokinetics of Anti-retroviral Agents That May be Considered for Future On-demand Peri-exposure HIV Prophylaxis Regimens

Emory University

NCT03976752

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 2
Phase 3 1

Named interventions

Most-linked intervention names on HIV/AIDS records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Peer Navigation Behavioral
3 trials
MyPEEPS Mobile Behavioral
2 trials
Control Behavioral
2 trials
mHealth N'Gage mobile application Other
1 trials
PlusCare Device
1 trials
DOORS-CHW Intervention Behavioral
1 trials
Combined Contingency Management and Peer Navigation Behavioral
1 trials
The BRIDGES Project Intervention Behavioral
1 trials

US sites by state

Facility locations filed on HIV/AIDS trials. A trial with sites in several states counts in each.

California 16 trials
New York 9 trials
North Carolina 5 trials
Pennsylvania 4 trials
Maryland 4 trials
Massachusetts 4 trials
Illinois 4 trials
Georgia 4 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this HIV/AIDS page

62 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HIV/AIDS condition card totals 62 registered trials; most-linked intervention Peer Navigation; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.