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Hepatocellular Carcinoma clinical trials
65 of 146 indexed Hepatocellular Carcinoma trials are currently recruiting.
146 US clinical trials · 65 currently recruiting
Hepatocellular Carcinoma is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 8 of these trials.
The research picture
Hepatocellular Carcinoma has 146 registered US clinical trials, 65 of them open to new participants right now, about 45% of the total.
- 65
- recruiting participants now
- 45%
- of trials open to enrollment
- 20
- in Phase 3–4 (later-stage)
- 8
- top sponsor: AstraZeneca
Active & Recent Trials
146 total, page 3 of 3
Sorafenib Plus Doxorubicin in Patients With Advanced Hepatocellular Carcinoma With Disease Progression on Sorafenib
Memorial Sloan Kettering Cancer Center
NCT01840592
Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma
National Cancer Institute (NCI)
NCT03937830
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers
Jonsson Comprehensive Cancer Center
NCT04459273
Pressure-enabled Delivery in Radioembolization (TriNav Study)
Massachusetts General Hospital
NCT05128032
SBRT + Atezolizumab + Bevacizumab in Resectable HCC
Massachusetts General Hospital
NCT04857684
Lipiodol Deposition Using Endhole vs. Pressure-Modulated Delivery
Abramson Cancer Center at Penn Medicine
NCT06204159
Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy
City of Hope Medical Center
NCT02432963
BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors
Sotio Biotech
NCT05120271
A Study to Assess Overall Survival and Treatment Patterns for Advanced Liver Cancer Participants Who Received Nivolumab Therapy
Bristol-Myers Squibb
NCT04161911
An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma
Bristol-Myers Squibb
NCT02576509
Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC)
Imunon
NCT00617981
Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC)
Imunon
NCT02112656
A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein
Eli Lilly and Company
NCT02435433
Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy
Daiichi Sankyo
NCT01755767
Prevention of Recurrent Hepatitis B After Liver Transplantation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00059267
Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms
University of Pittsburgh
NCT01640522
Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma
Celgene
NCT01177397
Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma
Pfizer
NCT01210495
EchoTip AcuCore Post-Market Clinical Study
Cook Research Incorporated
NCT06358001
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
Xencor
NCT03517488
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
Sanofi
NCT05104567
Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma
H3 Biomedicine
NCT02834780
Sorafenib Dose Ramp-Up in Hepatocellular Carcinoma (HCC)
University of Florida
NCT01203787
Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors
Kyowa Kirin
NCT02705105
Perflutren Protein-Type A Microspheres and Contrast-Enhanced Ultrasound in Improving Response to Radioembolization Therapy in Patients With Liver Cancer
Thomas Jefferson University
NCT03199274
E7050 in Combination With Sorafenib Versus Sorafenib Alone as First Line Therapy in Participants With Hepatocellular Carcinoma
Eisai
NCT01271504
A Study of Ramucirumab (LY3009806) Plus MEDI4736 in Participants With Advanced Gastrointestinal or Thoracic Malignancies
Eli Lilly and Company
NCT02572687
Evaluation of Liver Cancer With Magnetic Resonance Imaging (MRI)
Icahn School of Medicine at Mount Sinai
NCT01871545
Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant
Gilead Sciences
NCT01559844
INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors
Incyte Corporation
NCT04580485
Assessment of Liver Cancer Response to TACE Using MultiHance-Enhanced MRI.
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00539253
Genetic Profiling of Liver Cancer in Patients Undergoing Liver Transplantation
Baylor Research Institute
NCT02412579
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
Incyte Corporation
NCT03652077
TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers
Tempest Therapeutics
NCT03829436
Impact of Y90 Radiation Segmentectomy on HCC
Icahn School of Medicine at Mount Sinai
NCT03248375
RAD001 in Advanced Hepatocellular Carcinoma
Massachusetts General Hospital
NCT00516165
Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma
Northwestern University
NCT00846131
Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
NCT00802555
Identify Proteomic Biomarkers for Outcome Prediction of Locoregional Treatments for HCC
University of Texas Southwestern Medical Center
NCT04459468
STA-9090 in Patients With Advanced Hepatocellular Cancer
Massachusetts General Hospital
NCT01665937
A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy
Indiana University
NCT03338062
TRC105 for Liver Cancer That Has Not Responded to Sorafenib
National Cancer Institute (NCI)
NCT01375569
BOLD MRI and FMISO PET for the Assessment of Hypoxic Tumor Microenvironment in Patients with Oligometastatic Liver Cancer Undergoing Yttirum-90 Selective Internal Radiation Therapy
Emory University
NCT05250895
Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer
Polaris Group
NCT02101593
Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization
National Institutes of Health Clinical Center (CC)
NCT02471313
LC Drug Eluting Bead for Treatment of Liver Cancer Which Cannot be Surgically Removed
University of Pittsburgh
NCT00877071
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 47 |
| Phase 2 | 45 |
| Phase 3 | 17 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hepatocellular Carcinoma Trial Landscape
146 indexed Hepatocellular Carcinoma studies · 65 recruiting (45%).
Phase mix: 20 late (III/IV) vs 92 early (I/II).
Top sponsor: AstraZeneca (8 trials), 9 others listed. 46 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hepatocellular Carcinoma?
PlainTrial tracks 146 US clinical trials for Hepatocellular Carcinoma, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hepatocellular Carcinoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.