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ClinicalTrials.gov 65 recruiting now official registry

Hepatocellular Carcinoma clinical trials

65 of 146 indexed Hepatocellular Carcinoma trials are currently recruiting.

146 US clinical trials · 65 currently recruiting

Hepatocellular Carcinoma is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 8 of these trials.

The research picture

Hepatocellular Carcinoma has 146 registered US clinical trials, 65 of them open to new participants right now, about 45% of the total.

65
recruiting participants now
45%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: AstraZeneca
Phase 147Phase 245Phase 317Phase 43

Active & Recent Trials

146 total, page 3 of 3

ACTIVE NOT RECRUITING Phase 2 30 participants

Sorafenib Plus Doxorubicin in Patients With Advanced Hepatocellular Carcinoma With Disease Progression on Sorafenib

Memorial Sloan Kettering Cancer Center

NCT01840592

ACTIVE NOT RECRUITING Phase 2 27 participants

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

National Cancer Institute (NCI)

NCT03937830

ACTIVE NOT RECRUITING Phase 1 26 participants

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

Jonsson Comprehensive Cancer Center

NCT04459273

ACTIVE NOT RECRUITING NA 20 participants

Pressure-enabled Delivery in Radioembolization (TriNav Study)

Massachusetts General Hospital

NCT05128032

ACTIVE NOT RECRUITING Early Phase 1 20 participants

SBRT + Atezolizumab + Bevacizumab in Resectable HCC

Massachusetts General Hospital

NCT04857684

ACTIVE NOT RECRUITING NA 12 participants

Lipiodol Deposition Using Endhole vs. Pressure-Modulated Delivery

Abramson Cancer Center at Penn Medicine

NCT06204159

ACTIVE NOT RECRUITING Phase 1 11 participants

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

City of Hope Medical Center

NCT02432963

ACTIVE NOT RECRUITING Phase 1 7 participants

BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors

Sotio Biotech

NCT05120271

COMPLETED 1,426 participants

A Study to Assess Overall Survival and Treatment Patterns for Advanced Liver Cancer Participants Who Received Nivolumab Therapy

Bristol-Myers Squibb

NCT04161911

COMPLETED Phase 3 743 participants

An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma

Bristol-Myers Squibb

NCT02576509

COMPLETED Phase 3 701 participants

Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC)

Imunon

NCT00617981

COMPLETED Phase 3 554 participants

Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC)

Imunon

NCT02112656

COMPLETED Phase 3 399 participants

A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein

Eli Lilly and Company

NCT02435433

COMPLETED Phase 3 383 participants

Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy

Daiichi Sankyo

NCT01755767

COMPLETED 317 participants

Prevention of Recurrent Hepatitis B After Liver Transplantation

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00059267

COMPLETED NA 261 participants

Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms

University of Pittsburgh

NCT01640522

COMPLETED Phase 1 226 participants

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Celgene

NCT01177397

COMPLETED Phase 2 224 participants

Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma

Pfizer

NCT01210495

COMPLETED 183 participants

EchoTip AcuCore Post-Market Clinical Study

Cook Research Incorporated

NCT06358001

COMPLETED Phase 1 150 participants

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Xencor

NCT03517488

COMPLETED Phase 2 138 participants

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

Sanofi

NCT05104567

COMPLETED Phase 1 128 participants

Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Participants With Advanced Hepatocellular Carcinoma

H3 Biomedicine

NCT02834780

COMPLETED Phase 4 120 participants

Sorafenib Dose Ramp-Up in Hepatocellular Carcinoma (HCC)

University of Florida

NCT01203787

COMPLETED Phase 1 114 participants

Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors

Kyowa Kirin

NCT02705105

COMPLETED Phase 2 104 participants

Perflutren Protein-Type A Microspheres and Contrast-Enhanced Ultrasound in Improving Response to Radioembolization Therapy in Patients With Liver Cancer

Thomas Jefferson University

NCT03199274

COMPLETED Phase 1 102 participants

E7050 in Combination With Sorafenib Versus Sorafenib Alone as First Line Therapy in Participants With Hepatocellular Carcinoma

Eisai

NCT01271504

COMPLETED Phase 1 85 participants

A Study of Ramucirumab (LY3009806) Plus MEDI4736 in Participants With Advanced Gastrointestinal or Thoracic Malignancies

Eli Lilly and Company

NCT02572687

COMPLETED NA 84 participants

Evaluation of Liver Cancer With Magnetic Resonance Imaging (MRI)

Icahn School of Medicine at Mount Sinai

NCT01871545

COMPLETED Phase 2 61 participants

Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant

Gilead Sciences

NCT01559844

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED NA 45 participants

Assessment of Liver Cancer Response to TACE Using MultiHance-Enhanced MRI.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00539253

COMPLETED 40 participants

Genetic Profiling of Liver Cancer in Patients Undergoing Liver Transplantation

Baylor Research Institute

NCT02412579

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED NA 29 participants

Impact of Y90 Radiation Segmentectomy on HCC

Icahn School of Medicine at Mount Sinai

NCT03248375

COMPLETED Phase 1 28 participants

RAD001 in Advanced Hepatocellular Carcinoma

Massachusetts General Hospital

NCT00516165

COMPLETED Phase 1 24 participants

Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma

Northwestern University

NCT00846131

COMPLETED Phase 1 21 participants

Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT00802555

COMPLETED 17 participants

Identify Proteomic Biomarkers for Outcome Prediction of Locoregional Treatments for HCC

University of Texas Southwestern Medical Center

NCT04459468

COMPLETED Phase 1 16 participants

STA-9090 in Patients With Advanced Hepatocellular Cancer

Massachusetts General Hospital

NCT01665937

COMPLETED NA 15 participants

A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation Therapy

Indiana University

NCT03338062

COMPLETED Phase 2 11 participants

TRC105 for Liver Cancer That Has Not Responded to Sorafenib

National Cancer Institute (NCI)

NCT01375569

COMPLETED Early Phase 1 9 participants

BOLD MRI and FMISO PET for the Assessment of Hypoxic Tumor Microenvironment in Patients with Oligometastatic Liver Cancer Undergoing Yttirum-90 Selective Internal Radiation Therapy

Emory University

NCT05250895

COMPLETED Phase 1 8 participants

Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer

Polaris Group

NCT02101593

COMPLETED Phase 2 3 participants

Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization

National Institutes of Health Clinical Center (CC)

NCT02471313

COMPLETED Phase 2 2 participants

LC Drug Eluting Bead for Treatment of Liver Cancer Which Cannot be Surgically Removed

University of Pittsburgh

NCT00877071

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 45
Phase 3 17
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatocellular Carcinoma Trial Landscape

146 indexed Hepatocellular Carcinoma studies · 65 recruiting (45%).

Phase mix: 20 late (III/IV) vs 92 early (I/II).

Top sponsor: AstraZeneca (8 trials), 9 others listed. 46 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatocellular Carcinoma?

PlainTrial tracks 146 US clinical trials for Hepatocellular Carcinoma, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.