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ClinicalTrials.gov 65 recruiting now official registry

Hepatocellular Carcinoma clinical trials

65 of 146 indexed Hepatocellular Carcinoma trials are currently recruiting.

146 US clinical trials · 65 currently recruiting

Hepatocellular Carcinoma is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 8 of these trials.

The research picture

Hepatocellular Carcinoma has 146 registered US clinical trials, 65 of them open to new participants right now, about 45% of the total.

65
recruiting participants now
45%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: AstraZeneca
Phase 147Phase 245Phase 317Phase 43

Active & Recent Trials

146 total, page 2 of 3

RECRUITING Phase 1 25 participants

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Teclison

NCT02174549

RECRUITING Phase 4 24 participants

Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria

The Methodist Hospital Research Institute

NCT05185505

RECRUITING Phase 1 21 participants

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

Baylor College of Medicine

NCT06198296

RECRUITING Phase 1 21 participants

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

Seattle Children's Hospital

NCT07148050

RECRUITING NA 20 participants

Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment

University of Tennessee

NCT03686709

RECRUITING Phase 1 20 participants

Cryoablation and Arterial Infusion of SD-101 in Combination with Durvalumab and Tremelimumab

University of California, San Diego

NCT06710223

RECRUITING Phase 1 20 participants

T-Cell Therapy (ECT204) in Adults With Advanced HCC

Eureka Therapeutics

NCT04864054

RECRUITING Phase 1 20 participants

SIRT With Tremelimumab and Durvalumab for Resectable HCC

Jiping Wang, MD, PhD

NCT05701488

RECRUITING Phase 3 20 participants

Evaluating Novel Therapies in ctDNA Positive GI Cancers

Georgetown University

NCT05482516

RECRUITING Phase 2 20 participants

A Pilot Study of Liver Protection Using Prednisone for Patients Receiving Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

University of Michigan Rogel Cancer Center

NCT05901519

RECRUITING Phase 2 19 participants

The Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma (HCC)

Inova Health Care Services

NCT06789757

RECRUITING Phase 1 18 participants

SBRT With Atezo/Bev for HCC

Abramson Cancer Center at Penn Medicine

NCT05488522

RECRUITING NA 15 participants

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

University of California, Irvine

NCT05497531

RECRUITING Phase 2 12 participants

A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

Inova Health Care Services

NCT06007846

RECRUITING Phase 2 12 participants

AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

University of Florida

NCT05669339

ACTIVE NOT RECRUITING 2,990 participants

ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk

Exact Sciences Corporation

NCT05064553

ACTIVE NOT RECRUITING 1,810 participants

Extracellular RNA Markers of Liver Disease and Cancer

Mayo Clinic

NCT02908048

ACTIVE NOT RECRUITING Phase 3 1,324 participants

Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

AstraZeneca

NCT03298451

ACTIVE NOT RECRUITING 1,000 participants

Registry 17-009: Multi-Institutional Study Examining Patients With HCC Undergoing Liver Transplantation

Federico Aucejo

NCT06018857

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 3 908 participants

Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

AstraZeneca

NCT03847428

ACTIVE NOT RECRUITING Phase 3 837 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

Exelixis

NCT03755791

ACTIVE NOT RECRUITING Phase 3 760 participants

Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC

AstraZeneca

NCT05301842

ACTIVE NOT RECRUITING Phase 3 732 participants

A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma

Bristol-Myers Squibb

NCT04039607

ACTIVE NOT RECRUITING Phase 3 724 participants

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

AstraZeneca

NCT03778957

ACTIVE NOT RECRUITING Phase 3 687 participants

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

Hoffmann-La Roche

NCT05904886

ACTIVE NOT RECRUITING Phase 3 545 participants

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Bristol-Myers Squibb

NCT03383458

ACTIVE NOT RECRUITING Phase 3 534 participants

A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma

CStone Pharmaceuticals

NCT04194775

ACTIVE NOT RECRUITING Phase 2 433 participants

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

MedImmune

NCT02519348

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 2 184 participants

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03836352

ACTIVE NOT RECRUITING Phase 2 130 participants

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)

AbbVie

NCT05822752

ACTIVE NOT RECRUITING NA 120 participants

Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)

ABK Biomedical

NCT05953337

ACTIVE NOT RECRUITING Phase 2 109 participants

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

National Cancer Institute (NCI)

NCT02867592

ACTIVE NOT RECRUITING Phase 2 100 participants

TheraSphere With Durvalumab and Tremelimumab for HCC

Boston Scientific Corporation

NCT05063565

ACTIVE NOT RECRUITING NA 100 participants

Contrast-enhanced MRI in Detecting Benign and Malignant Liver Lesions

M.D. Anderson Cancer Center

NCT02156739

ACTIVE NOT RECRUITING Phase 1 94 participants

A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma

AstraZeneca

NCT06084884

ACTIVE NOT RECRUITING Phase 2 65 participants

Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients

Regeneron Pharmaceuticals

NCT03916627

ACTIVE NOT RECRUITING Phase 2 58 participants

Domvanalimab and Zimberelimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT05724563

ACTIVE NOT RECRUITING Phase 2 52 participants

Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis

National Cancer Institute (NCI)

NCT02968810

ACTIVE NOT RECRUITING Phase 2 48 participants

Neoadjuvant Nivolumab with CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC)

Icahn School of Medicine at Mount Sinai

NCT04123379

ACTIVE NOT RECRUITING NA 47 participants

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy

HistoSonics

NCT04572633

ACTIVE NOT RECRUITING Phase 2 45 participants

Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study

Northwestern University

NCT04550481

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING NA 40 participants

TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

Abramson Cancer Center at Penn Medicine

NCT01918683

ACTIVE NOT RECRUITING Phase 1 36 participants

Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function

M.D. Anderson Cancer Center

NCT02626312

ACTIVE NOT RECRUITING Phase 2 35 participants

A Study of Pembrolizumab and Bavituximab in Patients With Advanced Hepatocellular Carcinoma

David Hsieh

NCT03519997

ACTIVE NOT RECRUITING Phase 1 33 participants

DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

National Cancer Institute (NCI)

NCT02772003

ACTIVE NOT RECRUITING Phase 1 31 participants

Feasibility and Efficacy of Perioperative Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular Carcinoma (HCC)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04658147

ACTIVE NOT RECRUITING Phase 2 30 participants

Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant

Davendra Sohal

NCT05027425

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 45
Phase 3 17
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatocellular Carcinoma Trial Landscape

146 indexed Hepatocellular Carcinoma studies · 65 recruiting (45%).

Phase mix: 20 late (III/IV) vs 92 early (I/II).

Top sponsor: AstraZeneca (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatocellular Carcinoma?

PlainTrial tracks 146 US clinical trials for Hepatocellular Carcinoma, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.