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NCT05120271 · ClinicalTrials.gov registry record · Phase 1
BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors
A Phase 1 study of Hepatocellular Carcinoma and Merkel Cell Carcinoma, sponsored by SOTIO Biotech.
- Active
- Registry status
- Phase 1
- Development phase
- 7
- Enrollment target
- 8
- Study locations
NCT05120271: Active Phase 1 study of Hepatocellular Carcinoma and Merkel Cell Carcinoma, sponsored by SOTIO Biotech.
NCT05120271 is a Phase 1 study of Hepatocellular Carcinoma and Merkel Cell Carcinoma that is active but no longer recruiting, run by SOTIO Biotech. The registered enrollment target is 7 participants, below the 257-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (97% lower). The trial reports 8 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05120271, a Phase 1 study of Hepatocellular Carcinoma and Merkel Cell Carcinoma, is active but no longer recruiting, sponsored by SOTIO Biotech.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 7 participants
- Enrollment target
- 8
- Study locations
Study Summary
This is a first-in-human (FIH), Phase 1/2, open-label, multicenter study to assess safety and determine the recommended Phase 2 dose (RP2D) of BOXR1030 administration after lymphodepleting chemotherapy (LD chemotherapy) in subjects with glypican-3 positive (GPC3+) advanced solid tumors.
Primary Outcome
Defined using National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0 or American Society for Transplantation and Cellular Therapy (ASTCT) criteria for cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome.
Conditions Studied
Interventions
- BIOLOGICAL CAR-GPC3 T Cells
Study Locations (8)
Other
- Beatson Institute for Cancer Research Wolfson Wohl Cancer Research Centre - Glasgow
- University College London Hospitals NHS Foundation Trust - London
- The Royal Marsden NHS Foundation Trust - London
Texas
- Baylor Scott and White Research Institute - Dallas
- University of Texas MD Anderson Cancer Center - Houston
California
- Hoag Hospital Newport Beach - Newport Beach
Washington
- Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location - Seattle
Wisconsin
- Froedtert and Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2022-10-26 |
| Est. Completion | 2042-12 |
| Phase | Phase 1 |
What the registry record for NCT05120271 still lists
NCT05120271 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 257-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Hepatocellular Carcinoma appearing as the primary indexed condition, and to 1 intervention - of which CAR-GPC3 T Cells is the first listed.
NCT05120271 lists 8 locations in 5 states (Other, Texas, California).
Frequently Asked Questions
What is clinical trial NCT05120271 about?
NCT05120271 is a clinical study titled "BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors". This is a first-in-human (FIH), Phase 1/2, open-label, multicenter study to assess safety and determine the recommended Phase 2 dose (RP2D) of BOXR1030 administration after lymphodepleting chemotherapy (LD chemotherapy) in subjects with glypican-3 positive (GPC3+) advanced solid tumors.
What is the current status of trial NCT05120271?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 7 participants. The study started on 2022-10-26. Estimated completion is 2042-12.
What conditions does trial NCT05120271 study?
This clinical trial studies the following conditions: Hepatocellular Carcinoma, Merkel Cell Carcinoma, Myxoid/Round Cell Liposarcoma, Squamous Cell Carcinoma of the Lung.
What interventions are being tested in trial NCT05120271?
The interventions under investigation include: CAR-GPC3 T Cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT05120271?
This trial is sponsored by SOTIO Biotech, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05120271 being conducted?
This trial has 8 study locations across California, Texas, Washington, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05120271's enrollment target sits among peer trials
7 144th of 145 higher than 2 of 145 other Hepatocellular Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatocellular Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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