Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

NCT02867592 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.

Interventions

  • DRUG Cabozantinib S-malate
  • DRUG Cabozantinib
  • OTHER Pharmacological Study

Study Locations (20)

California

  • Kaiser Permanente-Anaheim — Anaheim
  • Kaiser Permanente-Bellflower — Bellflower
  • Kaiser Permanente Downey Medical Center — Downey
  • Kaiser Permanente-Fontana — Fontana
  • Loma Linda University Medical Center — Loma Linda
  • Children's Hospital Los Angeles — Los Angeles
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles
  • Valley Children's Hospital — Madera
  • UCSF Benioff Children's Hospital Oakland — Oakland
  • Kaiser Permanente-Oakland — Oakland
  • Children's Hospital of Orange County — Orange
  • Lucile Packard Children's Hospital Stanford University — Palo Alto
  • University of California Davis Comprehensive Cancer Center — Sacramento
  • Kaiser Permanente-San Diego Mission — San Diego
  • Rady Children's Hospital - San Diego — San Diego
  • UCSF Medical Center-Mission Bay — San Francisco

Alabama

  • Children's Hospital of Alabama — Birmingham

Alaska

  • Providence Alaska Medical Center — Anchorage

Arkansas

  • Arkansas Children's Hospital — Little Rock

Colorado

  • Children's Hospital Colorado — Aurora

Trial Details

FieldValue
Enrollment Target 109 participants
Start Date 2017-05-18
Est. Completion 2026-06-27
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02867592

The ClinicalTrials.gov registry entry for NCT02867592 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 109 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Hepatocellular Carcinoma appearing as the primary indexed condition, and to 3 interventions — of which Cabozantinib S-malate is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02867592 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Alabama, Alaska. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02867592 about?

NCT02867592 is a clinical study titled "Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors". This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzy...

What is the current status of trial NCT02867592?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 109 participants. The study started on 2017-05-18. Estimated completion is 2026-06-27.

What conditions does trial NCT02867592 study?

This clinical trial studies the following conditions: Hepatocellular Carcinoma, Osteosarcoma, Ewing Sarcoma, Hepatoblastoma, Central Nervous System Neoplasm. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02867592?

The interventions under investigation include: Cabozantinib S-malate (DRUG), Cabozantinib (DRUG), Pharmacological Study (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02867592?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02867592 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial