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NCT05301842 · ClinicalTrials.gov registry record · Phase 3
Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC
A Phase 3 study of Hepatocellular Carcinoma, sponsored by AstraZeneca.
- Active
- Registry status
- Phase 3
- Development phase
- 760
- Enrollment target
- 20
- Study locations
NCT05301842: Active Phase 3 study of Hepatocellular Carcinoma, sponsored by AstraZeneca.
NCT05301842 is a Phase 3 study of Hepatocellular Carcinoma that is active but no longer recruiting, run by AstraZeneca. The registered enrollment target is 760 participants, above the 252-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (202% higher). The trial reports 20 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05301842, a Phase 3 study of Hepatocellular Carcinoma, is active but no longer recruiting, sponsored by AstraZeneca.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 760 participants
- Enrollment target
- 20
- Study locations
Study Summary
A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab, tremelimumab and lenvatinib therapy in patients with locoregional hepatocellular carcinoma
Primary Outcome
PFS is defined as time from randomization until progression per RECIST 1.1 as assessed by BICR or death due to any cause
Conditions Studied
Interventions
- DRUG Lenvatinib
- DRUG Durvalumab
- DRUG Tremelimumab
- PROCEDURE Transarterial Chemoembolization (TACE)
Study Locations (20)
Other
- Research Site - Brussels
- Research Site - Ghent
- Research Site - Barretos
- Research Site - Brasília
- Research Site - Niterói
- Research Site - Porto Alegre
- Research Site - Rio de Janeiro
- Research Site - Santa Maria
Alabama
- Research Site - Birmingham
- Research Site - Mobile
New York
- Research Site - Commack
- Research Site - New York
Texas
- Research Site - Dallas
- Research Site - Houston
Arizona
- Research Site - Yuma
California
- Research Site - Glendale
Georgia
- Research Site - Atlanta
Maryland
- Research Site - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 760 participants |
| Start Date | 2022-03-28 |
| Est. Completion | 2027-02-26 |
| Phase | Phase 3 |
What the registry record for NCT05301842 still lists
NCT05301842 is an interventional study that assigns participants to a tested intervention. The registered 760 participants enrollment target is mid-sized for trials with a published cap, above the 252-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (202% higher).
The record links to 1 condition, with Hepatocellular Carcinoma appearing as the primary indexed condition, and to 4 interventions - of which Lenvatinib is the first listed.
NCT05301842 names 20 study sites across 10 states, led by Other, Alabama, New York.
Frequently Asked Questions
What is clinical trial NCT05301842 about?
NCT05301842 is a clinical study titled "Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC". A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab, tremelimumab and lenvatinib therapy in patients with locoregional hepatocellular carcinoma
What is the current status of trial NCT05301842?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 760 participants. The study started on 2022-03-28. Estimated completion is 2027-02-26.
What conditions does trial NCT05301842 study?
This clinical trial studies the following conditions: Hepatocellular Carcinoma.
What interventions are being tested in trial NCT05301842?
The interventions under investigation include: Lenvatinib (DRUG), Durvalumab (DRUG), Tremelimumab (DRUG), Transarterial Chemoembolization (TACE) (PROCEDURE).
Who is sponsoring clinical trial NCT05301842?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05301842 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Georgia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hepatocellular Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05301842's enrollment target sits among peer trials
760 13th of 145 higher than 133 of 145 other Hepatocellular Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatocellular Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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