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ClinicalTrials.gov 13 recruiting now official registry

Hepatitis C clinical trials

13 of 108 indexed Hepatitis C trials are currently recruiting.

108 US clinical trials · 13 currently recruiting

Hepatitis C is the subject of 108 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is Gilead Sciences, running 7 of these trials.

The research picture

Hepatitis C has 108 registered US clinical trials, 13 of them open to new participants right now, about 12% of the total.

13
recruiting participants now
12%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
7
top sponsor: Gilead Sciences
Phase 114Phase 223Phase 311Phase 410

Active & Recent Trials

108 total, page 1 of 3

RECRUITING 8,050 participants

Evaluation of Patients With Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001971

RECRUITING 1,200 participants

The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

University of Chicago

NCT01280825

RECRUITING 1,000 participants

Proteogenomic Monitoring and Assessment of Liver Transplant Recipients

Northwestern University

NCT01644903

RECRUITING 1,000 participants

Blood Collection Biorepository for Liver Disease Research

State University of New York at Buffalo

NCT03025074

RECRUITING 550 participants

The HOPE Study: Characterizing Patients With Hepatitis B and C

University of Maryland, Baltimore

NCT02995252

RECRUITING NA 500 participants

Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs

University of California, San Francisco

NCT06179498

RECRUITING 500 participants

The Hepatitis C Transplant Collaborative

Baylor Research Institute

NCT04493385

RECRUITING NA 418 participants

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

NCT03135886

RECRUITING NA 308 participants

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Johns Hopkins University

NCT04162938

RECRUITING NA 141 participants

DBS TaT in Peer-assisted Telemedicine for Hepatitis C

Oregon Health and Science University

NCT06409169

RECRUITING 100 participants

The Treatment in Pregnancy for Hepatitis C ("TiP-HepC") Registry

The Task Force for Global Health

NCT05368974

RECRUITING 50 participants

Feasibility and Acceptability of HCV Treatment in Pregnancy

Washington University School of Medicine

NCT06367465

RECRUITING NA 30 participants

HCV Tappt Adherence Study

University of Illinois at Chicago

NCT06263829

ACTIVE NOT RECRUITING Phase 4 200 participants

A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients

Mayo Clinic

NCT04508907

ACTIVE NOT RECRUITING NA 100 participants

Tele-Harm Reduction

University of Miami

NCT05208697

ACTIVE NOT RECRUITING NA 80 participants

Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants

Montefiore Medical Center

NCT04701437

ACTIVE NOT RECRUITING Phase 2 30 participants

The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients

Amit D Tevar, MD

NCT03809533

ACTIVE NOT RECRUITING NA 20 participants

Buprenorphine Integration Research and Community Health

Yale University

NCT05668780

ACTIVE NOT RECRUITING Phase 2 20 participants

Expanding the Pool in Orthotopic Heart Transplantation

Mary E. Keebler, MD

NCT03222531

COMPLETED NA 147,533 participants

The DETECT HCV Screening Trial

Denver Health and Hospital Authority

NCT04003454

COMPLETED 13,559 participants

HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network

University of North Carolina, Chapel Hill

NCT01474811

COMPLETED NA 7,634 participants

Improving Inpatient Screening for Hepatitis C

University of Pennsylvania

NCT04525690

COMPLETED Phase 3 943 participants

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir and Sofosbuvir/Velpatasvir in Adults With Chronic HCV Infection Who Have Not Previously Received Treatment With Direct-Acting Antiviral Therapy

Gilead Sciences

NCT02607800

COMPLETED 870 participants

Genetics of Hepatitis C Virus Infection

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00005657

COMPLETED 772 participants

An Observational Study of Hepatitis C Virus in Pregnancy

The George Washington University Biostatistics Center

NCT01959321

COMPLETED NA 755 participants

Patient-Centered Models of HCV Care for People Who Inject Drugs

Prisma Health-Upstate

NCT02824640

COMPLETED Phase 3 723 participants

Long Term Follow-up Study to Assess Durability of Sustained Virologic Response in Alisporivir-treated Hepatitis C Patients

Debiopharm International

NCT02753699

COMPLETED Phase 3 658 participants

Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-naïve Genotype 1 Hepatitis C Infected Patients (STARTverso 2)

Boehringer Ingelheim

NCT01297270

COMPLETED Phase 4 610 participants

Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC

Brooke Army Medical Center

NCT00207363

COMPLETED Phase 3 605 participants

Study Comparing Daclatasvir (BMS-790052) With Telaprevir Combined With Peginterferon Alfa-2a and Ribavirin in Patients With Chronic Hepatitis C Virus Infection

Bristol-Myers Squibb

NCT01492426

COMPLETED Phase 3 601 participants

SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection

Gilead Sciences

NCT01962441

COMPLETED 569 participants

Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection

National Institutes of Health Clinical Center (CC)

NCT01350648

COMPLETED Phase 3 527 participants

Phase 3 Study of Sofosbuvir and Ribavirin

Gilead Sciences

NCT01497366

COMPLETED NA 478 participants

Integrating HIV and Hepatitis C Screening in an Urban Emergency Department

New York City Health and Hospitals Corporation

NCT03252483

COMPLETED Phase 2 459 participants

Efficacy and Safety of Adding Alisporivir (DEB025) to Peginterferon (IFN) Alfa-2a (Peg-IFN Alfa-2a) and Ribavirin in Chronic HCV Genotype 1 Patients Who Relapsed or Did Not Respond to Previous Treatment

Debiopharm International

NCT01183169

COMPLETED Phase 3 416 participants

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy

Gilead Sciences

NCT02607735

COMPLETED 408 participants

Virology Follow up Study in Subjects Previously Treated With Telaprevir

Vertex Pharmaceuticals Incorporated

NCT00916474

COMPLETED Phase 3 401 participants

Hepatitis C Antiviral Resistance in African-Americans

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00038974

COMPLETED Phase 4 400 participants

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NCT03512210

COMPLETED Phase 3 394 participants

An Efficacy, Safety and Tolerability Study of TMC435 in Genotype 1 Hepatitis C-infected Patients Who Relapsed After Previous Therapy

Janssen R&D Ireland

NCT01281839

COMPLETED Phase 4 374 participants

The Kentucky Viral Hepatitis Treatment Study

Jennifer Havens

NCT03949764

COMPLETED 352 participants

Collection of Plasma and Serum Samples From Individuals Initiating Sofosbuvir for Chronic Hepatitis C for Testing

Hologic

NCT02068963

COMPLETED 330 participants

Brain Deficits in HIV/HCV Coinfected People Before and After Anti-HCV Therapy

University of California, Los Angeles

NCT00747539

COMPLETED NA 319 participants

Integrated Stepped Care for Unhealthy Alcohol Use in HIV

Yale University

NCT01410123

COMPLETED Phase 2 315 participants

Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C

Vertex Pharmaceuticals Incorporated

NCT00088504

COMPLETED Phase 4 312 participants

Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection

Baylor Research Institute

NCT00163657

COMPLETED NA 309 participants

Hepatitis C Translating Initiatives for Depression Into Effective Solutions

VA Office of Research and Development

NCT01143896

COMPLETED NA 300 participants

Comparing Brief Alcohol Interventions For HIV-HCV Co-infected Persons

Butler Hospital

NCT02316184

COMPLETED Phase 2 275 participants

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Atea Pharmaceuticals

NCT05904470

COMPLETED Phase 2 246 participants

A Study Evaluating the Safety and Clinical Activity of HCV-796 in Treatment-Naive and Non-Responder Subjects

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00367887

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Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 23
Phase 3 11
Phase 4 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatitis C Trial Landscape

108 indexed Hepatitis C studies · 13 recruiting (12%).

Phase mix: 21 late (III/IV) vs 37 early (I/II).

Top sponsor: Gilead Sciences (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatitis C?

PlainTrial tracks 108 US clinical trials for Hepatitis C, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatitis C?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.