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Hepatitis C clinical trials
13 of 108 indexed Hepatitis C trials are currently recruiting.
108 US clinical trials · 13 currently recruiting
Hepatitis C is the subject of 108 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is Gilead Sciences, running 7 of these trials.
The research picture
Hepatitis C has 108 registered US clinical trials, 13 of them open to new participants right now, about 12% of the total.
- 13
- recruiting participants now
- 12%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Gilead Sciences
Active & Recent Trials
108 total, page 1 of 3
Evaluation of Patients With Liver Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001971
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
University of Chicago
NCT01280825
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients
Northwestern University
NCT01644903
Blood Collection Biorepository for Liver Disease Research
State University of New York at Buffalo
NCT03025074
The HOPE Study: Characterizing Patients With Hepatitis B and C
University of Maryland, Baltimore
NCT02995252
Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs
University of California, San Francisco
NCT06179498
The Hepatitis C Transplant Collaborative
Baylor Research Institute
NCT04493385
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum
Johns Hopkins University
NCT04162938
DBS TaT in Peer-assisted Telemedicine for Hepatitis C
Oregon Health and Science University
NCT06409169
The Treatment in Pregnancy for Hepatitis C ("TiP-HepC") Registry
The Task Force for Global Health
NCT05368974
Feasibility and Acceptability of HCV Treatment in Pregnancy
Washington University School of Medicine
NCT06367465
HCV Tappt Adherence Study
University of Illinois at Chicago
NCT06263829
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
Mayo Clinic
NCT04508907
Tele-Harm Reduction
University of Miami
NCT05208697
Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants
Montefiore Medical Center
NCT04701437
The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients
Amit D Tevar, MD
NCT03809533
Buprenorphine Integration Research and Community Health
Yale University
NCT05668780
Expanding the Pool in Orthotopic Heart Transplantation
Mary E. Keebler, MD
NCT03222531
The DETECT HCV Screening Trial
Denver Health and Hospital Authority
NCT04003454
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network
University of North Carolina, Chapel Hill
NCT01474811
Improving Inpatient Screening for Hepatitis C
University of Pennsylvania
NCT04525690
Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir and Sofosbuvir/Velpatasvir in Adults With Chronic HCV Infection Who Have Not Previously Received Treatment With Direct-Acting Antiviral Therapy
Gilead Sciences
NCT02607800
Genetics of Hepatitis C Virus Infection
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00005657
An Observational Study of Hepatitis C Virus in Pregnancy
The George Washington University Biostatistics Center
NCT01959321
Patient-Centered Models of HCV Care for People Who Inject Drugs
Prisma Health-Upstate
NCT02824640
Long Term Follow-up Study to Assess Durability of Sustained Virologic Response in Alisporivir-treated Hepatitis C Patients
Debiopharm International
NCT02753699
Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-naïve Genotype 1 Hepatitis C Infected Patients (STARTverso 2)
Boehringer Ingelheim
NCT01297270
Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC
Brooke Army Medical Center
NCT00207363
Study Comparing Daclatasvir (BMS-790052) With Telaprevir Combined With Peginterferon Alfa-2a and Ribavirin in Patients With Chronic Hepatitis C Virus Infection
Bristol-Myers Squibb
NCT01492426
SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection
Gilead Sciences
NCT01962441
Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection
National Institutes of Health Clinical Center (CC)
NCT01350648
Phase 3 Study of Sofosbuvir and Ribavirin
Gilead Sciences
NCT01497366
Integrating HIV and Hepatitis C Screening in an Urban Emergency Department
New York City Health and Hospitals Corporation
NCT03252483
Efficacy and Safety of Adding Alisporivir (DEB025) to Peginterferon (IFN) Alfa-2a (Peg-IFN Alfa-2a) and Ribavirin in Chronic HCV Genotype 1 Patients Who Relapsed or Did Not Respond to Previous Treatment
Debiopharm International
NCT01183169
Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy
Gilead Sciences
NCT02607735
Virology Follow up Study in Subjects Previously Treated With Telaprevir
Vertex Pharmaceuticals Incorporated
NCT00916474
Hepatitis C Antiviral Resistance in African-Americans
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00038974
Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT03512210
An Efficacy, Safety and Tolerability Study of TMC435 in Genotype 1 Hepatitis C-infected Patients Who Relapsed After Previous Therapy
Janssen R&D Ireland
NCT01281839
The Kentucky Viral Hepatitis Treatment Study
Jennifer Havens
NCT03949764
Collection of Plasma and Serum Samples From Individuals Initiating Sofosbuvir for Chronic Hepatitis C for Testing
Hologic
NCT02068963
Brain Deficits in HIV/HCV Coinfected People Before and After Anti-HCV Therapy
University of California, Los Angeles
NCT00747539
Integrated Stepped Care for Unhealthy Alcohol Use in HIV
Yale University
NCT01410123
Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C
Vertex Pharmaceuticals Incorporated
NCT00088504
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
Baylor Research Institute
NCT00163657
Hepatitis C Translating Initiatives for Depression Into Effective Solutions
VA Office of Research and Development
NCT01143896
Comparing Brief Alcohol Interventions For HIV-HCV Co-infected Persons
Butler Hospital
NCT02316184
A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV
Atea Pharmaceuticals
NCT05904470
A Study Evaluating the Safety and Clinical Activity of HCV-796 in Treatment-Naive and Non-Responder Subjects
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00367887
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 14 |
| Phase 2 | 23 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hepatitis C Trial Landscape
108 indexed Hepatitis C studies · 13 recruiting (12%).
Phase mix: 21 late (III/IV) vs 37 early (I/II).
Top sponsor: Gilead Sciences (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hepatitis C?
PlainTrial tracks 108 US clinical trials for Hepatitis C, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hepatitis C?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.