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ClinicalTrials.gov 13 recruiting now official registry

Hepatitis C clinical trials

13 of 108 indexed Hepatitis C trials are currently recruiting.

108 US clinical trials · 13 currently recruiting

Hepatitis C is the subject of 108 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is Gilead Sciences, running 7 of these trials.

The research picture

Hepatitis C has 108 registered US clinical trials, 13 of them open to new participants right now, about 12% of the total.

13
recruiting participants now
12%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
7
top sponsor: Gilead Sciences
Phase 114Phase 223Phase 311Phase 410

Active & Recent Trials

108 total, page 2 of 3

COMPLETED Phase 2 207 participants

Antiviral & Antifibrotic Liver Therapy in HCV + Drinkers and Non-Drinkers

Icahn School of Medicine at Mount Sinai

NCT00211848

COMPLETED NA 200 participants

Development and Pilot Testing of a PHCI for Emergency Department Patients Who Decline Rapid HIV/ HCV Screening

Rhode Island Hospital

NCT04137094

COMPLETED Phase 3 173 participants

Phase III Daclatasvir and Sofosbuvir for Genotype 3 Chronic HCV

Bristol-Myers Squibb

NCT02032901

COMPLETED Phase 2 165 participants

Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin

Bristol-Myers Squibb

NCT01795911

COMPLETED Phase 2 165 participants

Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin

Bristol-Myers Squibb

NCT01309932

COMPLETED Phase 2 146 participants

Infliximab Treatment Along With Pegylated Interferon and Ribavirin in the Treatment of Hepatitis C

Nizar Zein

NCT00512278

COMPLETED Phase 4 122 participants

Prevention of De Novo HCV With Antiviral HCV Therapy Post-Liver and Post-Kidney Transplant

University of California, San Francisco

NCT03619837

COMPLETED Phase 3 119 participants

A Rollover Study of BI 201335 in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-experienced Genotype 1 Hepatitis C Infected Patients

Boehringer Ingelheim

NCT01330316

COMPLETED Phase 2 117 participants

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

Vertex Pharmaceuticals Incorporated

NCT00535847

COMPLETED Phase 2 116 participants

Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C

Medtronic Corporate Technologies and New Ventures

NCT00919633

COMPLETED Phase 2 115 participants

A Study of Albuferon With Ribavirin in Interferon Treatment Experienced Subjects With Chronic Hepatitis C

Human Genome Sciences

NCT00097435

COMPLETED NA 115 participants

Hepatitis C Education for Pregnant Women With Opiate Dependence - Phase 2

TriHealth

NCT03320889

COMPLETED Phase 1 111 participants

TD-6450 SAD and MAD in Healthy Subjects

Theravance Biopharma

NCT02022306

COMPLETED 100 participants

Anticipated and Perceived Benefits Following Hepatitis C Treatment

University of North Carolina, Chapel Hill

NCT03000023

COMPLETED NA 96 participants

HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention

Montefiore Medical Center

NCT03242655

COMPLETED Phase 4 87 participants

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

University of Maryland, Baltimore

NCT03823911

COMPLETED Phase 2 75 participants

SB497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Thrombocytopenia Due To Hepatitis C

GlaxoSmithKline

NCT00110799

COMPLETED Phase 2 73 participants

The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients

Fernanda P Silveira, MD, MS

NCT03819322

COMPLETED NA 71 participants

Evaluation of HepCure Toolkit to Improve Harvoni Adherence

Icahn School of Medicine at Mount Sinai

NCT02740556

COMPLETED NA 70 participants

Helping Empower Liver and Kidney Patients

Washington University School of Medicine

NCT03426787

COMPLETED Phase 2 67 participants

Study of CTS-1027 in Combination With Pegylated Interferon and Ribavirin in Hepatitis C Virus (HCV) Null-Responders

Conatus Pharmaceuticals

NCT01051921

COMPLETED Phase 2 61 participants

Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant

Gilead Sciences

NCT01559844

COMPLETED Phase 1 60 participants

GS-7977 With Ribavirin for Hepatitis C (SPARE)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01441180

COMPLETED 60 participants

History of Hepatitis C in Volunteer Blood Donors

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001982

COMPLETED Phase 1 56 participants

Phase I Trial of Silymarin for Chronic Liver Diseases

National Center for Complementary and Integrative Health (NCCIH)

NCT00389376

COMPLETED Phase 1 52 participants

Single and Multiple Dose Evaluation of ABT-072 and to Evaluate the Effect of Food on the Pharmacokinetics of ABT-072

Abbott

NCT00982826

COMPLETED 52 participants

Eliminating Hepatitis C Virus

Icahn School of Medicine at Mount Sinai

NCT03401697

COMPLETED NA 50 participants

Feasibility of a Hepatitis C Virus (HCV) Decision-Making Intervention Among HIV-infected Adults

University of Massachusetts, Worcester

NCT01472354

COMPLETED Phase 2 48 participants

Study of FK788 in Subjects With Chronic Hepatitis C Virus Infection

Astellas Pharma

NCT00047814

COMPLETED Phase 2 47 participants

Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3

Gilead Sciences

NCT01808248

COMPLETED Phase 1 47 participants

TD-6450 MAD Study in HCV Infected Subjects

Theravance Biopharma

NCT02116543

COMPLETED NA 42 participants

Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1

National Institute on Drug Abuse (NIDA)

NCT00218556

COMPLETED Phase 1 40 participants

Drug Interaction Study Between Eltrombopag and Lopinavir/Ritonavir in Healthy Adult Subjects.

GlaxoSmithKline

NCT00833378

COMPLETED NA 39 participants

HCV Seek, Test and Rapid Treatment for Young PWID

Weill Medical College of Cornell University

NCT03627546

COMPLETED Phase 2 35 participants

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01888900

COMPLETED Phase 1 32 participants

Study of Bavituximab in Patients With Chronic Hepatitis C Virus Infection

Peregrine Pharmaceuticals

NCT00128271

COMPLETED Phase 1 30 participants

Interaction of Alcohol and Highly Active Antiretroviral Therapy (HAART) in HIV/AIDS and HIV/AIDS With Hepatitis C Virus (HCV) Co-Infection

University of California, San Francisco

NCT00879047

COMPLETED Phase 1 30 participants

Evaluating the Safety of ITX 5061 in Treatment-Naive Hepatitis C (HCV)-Infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01165359

COMPLETED Phase 1 29 participants

Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00393276

COMPLETED Phase 1 28 participants

Proof of Concept Study for Safety and Efficacy of EDP239 in Hepatitis C Subjects

Enanta Pharmaceuticals

NCT01856426

COMPLETED NA 26 participants

Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers

University of Colorado, Denver

NCT01427504

COMPLETED NA 25 participants

Rapid Hepatitis C Elimination Trial- A Pilot Study of Daclatasvir/Asunaprevir/BMS-791325 With or Without Ribavirin To Treat Hepatitis C Virus

Timothy Morgan, MD

NCT02098616

COMPLETED Phase 1 24 participants

Open-Label Hepatic Impairment Study

Gilead Sciences

NCT01497327

COMPLETED Phase 2 22 participants

Treatment of Hepatitis C in Hemophilic Patients With HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00055341

COMPLETED Phase 4 21 participants

Treatment of Acute Hepatitis C Virus in HIV Co-Infection

University of California, San Francisco

NCT00845676

COMPLETED Phase 1 20 participants

Cross-Over Study to Assess the Cardiovascular Effects of GSK2336805

GlaxoSmithKline

NCT01424540

COMPLETED Phase 1 20 participants

A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults

Vertex Pharmaceuticals Incorporated

NCT01038167

COMPLETED Phase 4 20 participants

Efficacy of Actos Lipitor Pegasys & Ribavirin in CHC GT 1 Patients Who Relapsed or Nonresponded to Peg/Riba

Brooke Army Medical Center

NCT00926614

COMPLETED 17 participants

Non-invasive Biomarkers of Fibrosis in Pediatric Liver Diseases

Baylor College of Medicine

NCT01988753

COMPLETED Phase 2 16 participants

Dose Finding Trial of Rosuvastatin and Atorvastatin Versus Hepatitis C

Bader, Ted, M.D.

NCT00446940

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Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 23
Phase 3 11
Phase 4 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatitis C Trial Landscape

108 indexed Hepatitis C studies · 13 recruiting (12%).

Phase mix: 21 late (III/IV) vs 37 early (I/II).

Top sponsor: Gilead Sciences (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatitis C?

PlainTrial tracks 108 US clinical trials for Hepatitis C, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatitis C?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.