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HIV Infection clinical trials
Every US clinical trial registered for HIV Infection — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
73 US clinical trials · 9 currently recruiting
The research picture
HIV Infection has 73 registered US clinical trials, 9 of them open to new participants right now — about 12% of the total.
- 9
- recruiting participants now
- 12%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 12
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02140255
Suubi-Mhealth: A Mobile Health Intervention to Address Depression Among Youth
Washington University School of Medicine
NCT05965245
Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers
AIDS Malignancy Consortium
NCT05663502
Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study
AIDS Malignancy Consortium
NCT04949464
HIV+ Deceased Donor Heart Transplant Study for HIV+ Recipients
University of Texas Southwestern Medical Center
NCT06659952
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
National Cancer Institute (NCI)
NCT04929028
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
AIDS Malignancy Consortium
NCT05077527
MAPS PrEP Van Study
Duke University
NCT06908252
The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
Icahn School of Medicine at Mount Sinai
NCT05652088
A Study of Doravirine/Islatravir (DOR/ISL, MK-8591A) for the Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection in Participants Who Previously Received DOR/ISL (MK-8591A-054)
Merck Sharp & Dohme
NCT05766501
Anal Cytology Collection Procedures in Predicting High-Grade Anal Dysplasia in Men Who Have Sex With Men
Jonsson Comprehensive Cancer Center
NCT02816879
Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04340596
A Study of Teropavimab and Zinlirvimab in Combination With Capsid Inhibitor Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection
Gilead Sciences
NCT05729568
Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection
AIDS Malignancy Consortium
NCT02437851
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant
AIDS Malignancy Consortium
NCT02797470
Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
City of Hope Medical Center
NCT02337985
Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
City of Hope Medical Center
NCT01961063
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
AIDS Malignancy Consortium
NCT02135419
Comparative Study of Three NNRTI-Sparing HAART Regimens
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT00811954
IMPAACT 1077HS: Examining Benefits of HAART Continuation in Postpartum Women
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
NCT00955968
Study of Patients With Strongyloides Stercoralis Infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001245
Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018)
Merck Sharp & Dohme
NCT04223791
B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04193189
Development of Serologic Assays for Human Herpes Virus-8
National Institutes of Health Clinical Center (CC)
NCT00395278
Evaluation of Behavioral Intervention for HIV Positive Prisoners in NC and TX
University of North Carolina, Chapel Hill
NCT01629316
A New Tablet Containing Two FDA-Approved Drugs In HIV-Infected Patients Who Have Not Received Prior Therapy
GlaxoSmithKline
NCT00053638
Hepatitis B Vaccine Genetics: A Substudy of ATN 024 and ATN 025
University of North Carolina, Chapel Hill
NCT00142740
Safety and Efficacy Study of Switching From Epzicom to Truvada
Gilead Sciences
NCT00724711
Effects of HIV on the Development and Function of Bone Marrow Cells
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001243
HLA-B*5701 And Hypersensitivity To Abacavir
GlaxoSmithKline
NCT00373945
Improving Immunogenicity of Influenza Vaccine in HIV Infected Individuals
University of Pennsylvania
NCT01262846
Physician Focused Intervention to Improve Adherence With HIV Antiretrovirals
National Institute on Drug Abuse (NIDA)
NCT00870792
Efficacy of Simplified Two Drug Kaletra Regimen vs. Kaletra Triple Drug Standard of Care Regimen in Treatment naïve HIV Infected Patients
Abbott
NCT00234910
Evaluation of Genetic Markers as Explanations for the Observed Differences in Disease Progression in HIV+ Youth
University of North Carolina, Chapel Hill
NCT00107029
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001524
Observational Study of HIV+ Deceased Donor Transplant for HIV+ Recipients
Johns Hopkins University
NCT02602262
Impact of a Human Papilloma Virus (HPV) Vaccine in HIV-Infected Young Women
University of North Carolina, Chapel Hill
NCT00710593
Capravirine to Treat Children With HIV Infection
National Cancer Institute (NCI)
NCT00006519
Factors Affecting Patient Participation in AIDS Malignancy Clinical Trials Consortium Clinical Trials
AIDS Malignancy Consortium
NCT01946217
Subcutaneously Administered Interleukin-2 Therapy in HIV-Infected Patients
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001357
A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years
ViiV Healthcare
NCT00040664
A Multicenter Study to Assess the Tolerability of Once Daily Lopinavir/Ritonavir (LPV/r) Liquid Versus Capsules
University of California, San Diego
NCT00281606
Study on Immunopathogenesis in HIV and Hepatitis C Coinfection
Rush University Medical Center
NCT01296529
The Effect of Vitamin D and Calcium on Bone in Pediatric HIV
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00724178
A Study To Evaluate Formulations And Food Effect On GSK364735 In Healthy Subjects.
GlaxoSmithKline
NCT00386347
A Trial to Determine the Long-term Durability of Virologic Suppression in Kaletra Recipients With Imperfect Adherence
Montefiore Medical Center
NCT00785616
Observation of HIV-Infected Children Receiving Protease Inhibitor and Reverse Transcriptase Inhibitor
National Cancer Institute (NCI)
NCT00001826
Switch to Atazanavir and Brachial Artery Reactivity (SABAR) Study
Northwestern University
NCT00225017
Twins Study of Gene Therapy for HIV Infection
National Human Genome Research Institute (NHGRI)
NCT00001535
Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults
International AIDS Vaccine Initiative
NCT00252148
Use of Combined Antiretroviral Therapy to Determine Sites of Persistent HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001644
A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1
AbbVie
NCT04223804
The Role of Ampligen in Strategic Therapeutic Intervention (STI) of HAART
AIM ImmunoTech
NCT00035893
Immune and Viral Status of HIV-Infected Patients After Stopping Combination Antiretroviral Therapy
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001899
Evaluation of Barriers to Postpartum Care in HIV Infected Women
The University of Texas Health Science Center, Houston
NCT01853917
Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus
National Cancer Institute (NCI)
NCT01822522
Boosted Lexiva With Lovaza Adjunctive Therapy in Hypertriglyceridemic, HIV-Infected Subjects
Felizarta, Franco, M.D.
NCT01010399
Influence of Antiretroviral Regimen on Immune Reconstitution in the Female Genital Tract
University of Colorado, Denver
NCT01456962
Pharmacodynamics of Intermittent IL-2 Infusions in HIV Seropositive Patients
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001474
Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination With Synthetic HIV Envelope Peptides in Patients With Early Human Immunodeficiency Virus Infection
National Cancer Institute (NCI)
NCT00001386
Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB060-00-AB (VRC01), Administered Intravenously or Subcutaneously to Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01993706
Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir
Robert L. Murphy
NCT00976404
Androgen Effects in HIV-infected Women
Massachusetts General Hospital
NCT00095212
Continued Antiretroviral Therapy With Abacavir, Amprenavir and Efavirenz
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001758
Technology-based Training Tool for PHAT Life
Oregon Research Behavioral Intervention Strategies
NCT05339412
Pharmacokinetics of Antiretroviral Agents in HIV-1 Infected Pregnant Women
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00006320
The Effect of Milk Thistle on the Pharmacokinetics of Indinavir
National Institutes of Health Clinical Center (CC)
NCT00011635
Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients
Sangamo Therapeutics
NCT01044654
Evaluation of the Safety of a Polyvalent Virus in Healthy Adults
St. Jude Children's Research Hospital
NCT00187044
Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy
Massachusetts General Hospital
NCT02471430
SNAP: Switching Nucleoside Analogues Protocol - Lipoatrophy and Mitochondrial Function
Northwestern University
NCT00225082
Immune Activation and Drug Absorption in HIV-Infected Patients
Drexel University
NCT01845298
IMPAACT P1107: Effects of Cord Blood Transplantation With CCR5Δ32 Donor Cells on HIV Persistence
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
NCT02140944
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 20 |
| Phase 2 | 12 |
| Phase 3 | 8 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Infection Trial Landscape
ClinicalTrials.gov lists 73 US studies indexed under HIV Infection, and 9 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for HIV Infection shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for HIV Infection is led by National Institute of Allergy and Infectious Diseases (NIAID) with 12 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 73 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV Infection?
PlainTrial tracks 73 US clinical trials for HIV Infection, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV Infection?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.