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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 8 of 8
Mobile Health Monitoring Solution for Heart Failure Patients
Atlantic Health System
NCT02594007
Daxor - Blood Volume Analysis
Duke University
NCT04111185
Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy
Johns Hopkins University
NCT01924221
Evaluation of the Hemocompatibility of the Direct Oral Anti-Coagulant Apixaban in Left Ventricular Assist Devices
Palak Shah
NCT04865978
A Tele-Health Symptom Management Program for Patients With Heart Failure: Pall-Heart
University of Virginia
NCT04120857
The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation
Deborah Ascheim
NCT01442129
Rehabilitation and Exercise Training After Hospitalization
Wake Forest University
NCT01508650
Furoscix Real-World Evaluation for Decreasing Hospital Admissions in Heart Failure
scPharmaceuticals
NCT03458325
The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation
Josef Stehlik
NCT05420012
M. D. Anderson Symptom Inventory - Heart Failure (MDASI-HF) Symptom Management Program
M.D. Anderson Cancer Center
NCT00827801
Beta-2 Polymorphisms and Beta Receptor Selectivity
University of Wisconsin, Madison
NCT00214318
Observational Study of ICD and Pacemaker Sensing in the Presence of IMED-4 Operation
Intersection Medical
NCT02191696
Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults
Mayo Clinic
NCT04996719
Monitoring Subjects With Fluid-Management Issues In the Home Environment
Baxter Healthcare Corporation
NCT02190877
Pericardial Resection to Treat Heart Failure
Mayo Clinic
NCT03073668
Feasibility of an Integrated Patient Care (IPC) System Using Daily Filling Pressures
Medtronic Cardiac Rhythm and Heart Failure
NCT01370564
Nutritional Therapy for Autonomic Dysfunction in Elderly Heart Failure Patients
University of Arkansas
NCT06256276
Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function
University of California, San Diego
NCT01671514
Pilot Study of Using Copeptin to Predict Response to Tolvaptan
University of North Carolina, Chapel Hill
NCT01346072
Oral Nitrite for Older Heart Failure Patients
Gladwin, Mark, MD
NCT02457260
Nesiritide and Vo2 Max in Heart Failure Patients
University of Rochester
NCT00240084
ECG Belt to Assess Electrical Synchronization
Pugazhendhi Vijayaraman
NCT04583709
Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure
Sarfez Pharmaceuticals
NCT06995144
The CASCADE HF Soft Launch and Calibration Phase I and II
Endeavor Health
NCT04738279
Abdominal Nerve Blockade in Chronic Heart Failure.
Duke University
NCT03453151
Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)
University of Wisconsin, Madison
NCT00585806
Sex and Obesity: Effects on Heart Failure Study
Washington University School of Medicine
NCT00776035
Proactive Palliative Care for Patients With Ventricular Assist Devices (VAD) and Their Families
Icahn School of Medicine at Mount Sinai
NCT01427634
Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction
Trevena
NCT01444872
Dietary Nitrate for Heart Failure
Washington University School of Medicine
NCT01682356
Pressure Variability Study
Medtronic Cardiac Rhythm and Heart Failure
NCT02943941
Study of Left Ventricular Dyssynchrony in Heart Failure Patients
Albert Einstein Healthcare Network
NCT00953953
Interventions to Improve Daily Activity in Heart Failure
Grand Valley State University
NCT02331524
Atrio-Ventricular (AV) Delay Optimization Using Echocardiography Versus the SonR Signal
Piedmont Healthcare
NCT01287234
The Development of Tolerance to α1-Adrenoceptor Blockade With Chronic Carvedilol Treatment
University of Utah
NCT00585091
Clinical Hemodynamic Study of Balloon Counterpulsation in Advanced Heart Failure
Tufts Medical Center
NCT03001674
Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement
Stanford University
NCT01717209
Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure
University of North Carolina, Chapel Hill
NCT01925703
Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF
University of Pennsylvania
NCT02256345
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal Function
Amgen
NCT03318809
AZD8601 Study in CABG Patients
AstraZeneca
NCT03370887
A Pilot Study of Dietary Chloride Supplementation on Cardiorenal Function in Heart Failure
Yale University
NCT02031354
Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
University of Utah
NCT02547766
Myocardial Hemodynamic Effects of Levosimendan
University of Utah
NCT00585104
Rural Home Hospital: Proof of Concept
Brigham and Women's Hospital
NCT04531280
Bone Marrow Derived Mesenchymal Stem Cells in Improving Heart Function in Patients With Heart Failure Caused by Anthracyclines
M.D. Anderson Cancer Center
NCT02408432
Cardiac Resynchronization Therapy (CRT) and Left Ventricular Assist Devices (LVAD) Therapy
University of Florida
NCT02083419
Hepatitis C Virus (HVC) Positive Heart Grafts in HCV Negative Recipients
Loma Linda University
NCT04452578
Lymph Drainage in Heart Failure
Duke University
NCT05240638
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.