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NCT02408432 · ClinicalTrials.gov registry record · Phase 1

Bone Marrow Derived Mesenchymal Stem Cells in Improving Heart Function in Patients With Heart Failure Caused by Anthracyclines

A Phase 1 study of Heart Failure and Cardiomyopathy, sponsored by M.D. Anderson Cancer Center.

Completed
Registry status
Phase 1
Development phase
7
Enrollment target
1
Study location

NCT02408432: Completed Phase 1 study of Heart Failure and Cardiomyopathy, sponsored by M.D. Anderson Cancer Center.

NCT02408432 is a Phase 1 study of Heart Failure and Cardiomyopathy that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 7 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT02408432, a Phase 1 study of Heart Failure and Cardiomyopathy, has completed, sponsored by M.D. Anderson Cancer Center.

COMPLETED
Registry status
Phase 1
Development phase
7 participants
Enrollment target
1
Study location

Study Summary

This randomized pilot phase I trial studies the side effects and best method of delivery of bone marrow derived mesenchymal stem cells (MSCs) in improving heart function in patients with heart failure caused by anthracyclines (a type of chemotherapy drug used in cancer treatment). MSCs are a type of stem cell that can be removed from bone marrow and grown into many different cell types that can be used to treat cancer and other diseases, such as heart failure. Bone marrow derived MSCs may promote heart muscle cells repair and lead to reverse remodeling and ultimately improve heart function and decrease morbidity and mortality from progression to advanced heart failure.

Primary Outcome

Statistical analyses of safety will be descriptive. In particular, will provide a table of adverse events.

Conditions Studied

Heart Failure Cardiomyopathy

Interventions

  • OTHER Standard of Care
  • OTHER Laboratory Biomarker Analysis
  • DRUG Mesenchymal Stem Cell Transplantation

Study Locations (1)

Texas

  • M D Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 7 participants
Start Date 2016-01-11
Est. Completion 2021-12-08
Phase Phase 1
M.D. Anderson Cancer Center

2,692 total trials

What the finished NCT02408432 record still lists

NCT02408432 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (100% lower).

The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 3 interventions - of which Standard of Care is the first listed.

NCT02408432 reports a single indexed study location in Texas.

Frequently Asked Questions

What is clinical trial NCT02408432 about?

NCT02408432 is a clinical study titled "Bone Marrow Derived Mesenchymal Stem Cells in Improving Heart Function in Patients With Heart Failure Caused by Anthracyclines". This randomized pilot phase I trial studies the side effects and best method of delivery of bone marrow derived mesenchymal stem cells (MSCs) in improving heart function in patients with heart failure caused by anthracyclines (a type of chemotherapy drug used in cancer treatment). MSCs are a type of...

What is the current status of trial NCT02408432?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 7 participants. The study started on 2016-01-11. Estimated completion is 2021-12-08.

What conditions does trial NCT02408432 study?

This clinical trial studies the following conditions: Heart Failure, Cardiomyopathy.

What interventions are being tested in trial NCT02408432?

The interventions under investigation include: Standard of Care (OTHER), Laboratory Biomarker Analysis (OTHER), Mesenchymal Stem Cell Transplantation (DRUG).

Who is sponsoring clinical trial NCT02408432?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02408432 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Heart Failure

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT02408432's enrollment target sits among peer trials

7 392nd of 397 higher than 5 of 397 other Heart Failure trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT02408432, the US trial registry maintained by the National Library of Medicine. NCT02408432 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.