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NCT01924221 · ClinicalTrials.gov registry record
Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy
A clinical trial of Heart Failure and Patients Undergoing CRT-D Device Implantation, sponsored by Johns Hopkins University.
- Completed
- Registry status
- 31
- Enrollment target
- 1
- Study location
NCT01924221: Completed study of Heart Failure and Patients Undergoing CRT-D Device Implantation, sponsored by Johns Hopkins University.
NCT01924221 is a study of Heart Failure and Patients Undergoing CRT-D Device Implantation that has completed, run by Johns Hopkins University. The registered enrollment target is 31 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01924221, a study of Heart Failure and Patients Undergoing CRT-D Device Implantation, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.
Primary Outcome
correlation between electrical and mechanical measures of dyssynchrony
Conditions Studied
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2011-12 |
| Est. Completion | 2022-08-01 |
What the finished NCT01924221 record still lists
NCT01924221 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 0 interventions.
NCT01924221 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT01924221 about?
NCT01924221 is a clinical study titled "Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy". Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resyn...
What is the current status of trial NCT01924221?
This trial is currently completed. The enrollment target is 31 participants. The study started on 2011-12. Estimated completion is 2022-08-01.
What conditions does trial NCT01924221 study?
This clinical trial studies the following conditions: Heart Failure, Patients Undergoing CRT-D Device Implantation.
Who is sponsoring clinical trial NCT01924221?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01924221 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01924221's enrollment target sits among peer trials
31 319th of 397 higher than 77 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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