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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 7 of 8
Self-management Adherence in Heart Failure Patients
University of Nebraska
NCT01964053
Leveraging Home Health Aides to Improve Outcomes in Heart Failure
Weill Medical College of Cornell University
NCT04239911
Tai Chi Mind-Body Therapy for Chronic Heart Failure
Beth Israel Deaconess Medical Center
NCT00110227
Creation of a Digital Heart Failure Registry Using a Novel Mobile Health Platform: HUGO-HF
Yale University
NCT03810638
Animal-Assisted Therapy for Hospitalized Heart Failure Patients
University of California, Los Angeles
NCT00391456
Cardiac Resynchronization Therapy Defibrillator Based Impedance Monitoring Study
Abbott Medical Devices
NCT00500838
Identifying Diuretic Resistance in Patients With Acute Heart Failure
Vanderbilt University
NCT02751242
Oxygen Versus PAP for Sleep Apnea in Heart Failure
VA Office of Research and Development
NCT01807897
Model 4965 Post-Approval Study
Medtronic
NCT01076348
Pivotal Bioequivalence Study to Qualify Manufacturing Site Transfer for Prazosin Hydrochloride Capsules
Pfizer
NCT04967443
Establishing a Non-invasive Method to Measure Your Heart's Performance
Marie Csete MD, PhD
NCT02240979
Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation Study
Duke University
NCT03775759
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome
VA Office of Research and Development
NCT03170375
Disease Management Platform for Heart Failure (DMP-HF)
Massachusetts General Hospital
NCT04782973
Exercise and Cognitive Retraining to Improve Cognition in Heart Failure.
Emory University
NCT02151266
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
Abramson Cancer Center at Penn Medicine
NCT04023110
BVA-200 vs BVA-100 Validation Study
Daxor Corporation
NCT06227819
Monocyte Phenotypic Changes in Heart Failure
University of Michigan
NCT02997462
Evaluating Myocardial Injury for Defibrillation Threshold Testing Methods for ICD Implantation
University of California, San Diego
NCT02111993
Strategies for Aggressive Central Afterload Reduction in Patients With Heart Failure
Mayo Clinic
NCT00588692
Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure
Vanderbilt University
NCT02606253
Study of Reminding to Improve Medication Adherence in Heart Failure
Kent State University
NCT01463267
Interleukin-1 Blockade in Recently Decompensated Heart Failure
Virginia Commonwealth University
NCT01936909
PK/PD Study of Subcutaneous Cenderitide Infusion in CHF Patients
Nile Therapeutics
NCT01316432
Teach-Back Discharge Education to Improve Self-Care and Reduce 30-Day Readmissions in Heart Failure Patients
Nova Southeastern University
NCT07280208
Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement
Thomas Jefferson University
NCT03243942
Frailty in Children With Cardiac Disease
Children's Mercy Hospital Kansas City
NCT02999438
Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure
Michael E. DeBakey VA Medical Center
NCT01261065
The Cascade Feasibility Pilot (HF) Phase 3
Endeavor Health
NCT04993287
Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children
University of Colorado, Denver
NCT02728128
Guideline Directed Medical Therapy (GDMT) Optimization and Adherence Longitudinal Study for Heart Failure.
Tricog Health
NCT05906745
Focused Palliative Care Intervention in Advanced Heart Failure
Brigham and Women's Hospital
NCT02805712
RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators
University of California, San Diego
NCT02111980
A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function
Bristol-Myers Squibb
NCT03357731
Body Composition Ultrasound for Patients With Heart Failure
Tufts Medical Center
NCT03948776
Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure
Yale University
NCT05093621
Mindfulness & Stress Management Study for Cardiac Patients
University of Minnesota
NCT02722213
RecoverLINK Technology Pilot for HF Patients
RecoverLINK
NCT02815085
Comparison of CorWatch With Right Heart Catheter Measurements in Heart Failure
InCardia
NCT04928326
Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
The University of Texas Health Science Center, Houston
NCT00178633
Values-Affirmation + Education Intervention Targeting Medication Adherence in Older Adults With Heart Failure
The Miriam Hospital
NCT05575375
Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response
Washington University School of Medicine
NCT02797184
Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1
The University of Texas Health Science Center at San Antonio
NCT03560323
Sensor-controlled Digital Game for Heart Failure Self-management
University of Texas at Austin
NCT03947983
Implantable Cardioverter Defibrillator (ICD) Function During Ventricular Assist Device (VAD) Implantation
Virginia Commonwealth University
NCT01576562
Vitamin C Supplementation Intervention
University of North Carolina, Chapel Hill
NCT04036110
Extracorporeal Ultrafiltration (UF) vs. Usual and Customary Care for Patients With Severe Heart Failure (HF)
NxStage Medical
NCT00288587
Heart Sounds Measurement Using the Wearable Cardioverter Defibrillator (HS-WCD) Study
Zoll Medical Corporation
NCT02825966
Heart Failure Resilience Intervention for Caregivers
Johns Hopkins University
NCT03963583
Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction
University of Pittsburgh
NCT03015402
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.