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NCT00585104 · ClinicalTrials.gov registry record · Phase 2
Myocardial Hemodynamic Effects of Levosimendan
A Phase 2 study of Heart Failure, sponsored by University of Utah.
- Completed
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT00585104: Completed Phase 2 study of Heart Failure, sponsored by University of Utah.
NCT00585104 is a Phase 2 study of Heart Failure that has completed, run by University of Utah. The registered enrollment target is 10 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00585104, a Phase 2 study of Heart Failure, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will test the hypothesis that mechanical efficiency as measured by pressure-volume loop assessment should improve during short-term treatment with intravenous levosimendan. Levosimendan (SimdaxTM, Abbott Laboratories, Abbott Park, IL) is a calcium sensitizer which has been shown to have beneficial hemodynamic effects in patients with decompensated congestive heart failure (CHF). Levosimendan is a new calcium sensitizer that binds to troponin C. This agent is approved in Europe for treatment of heart failure patients. In the United States, this agent is currently under phase III investigation for intravenous treatment of patients with acutely decompensated HF who have dyspnea at rest or with minimal activity. Levosimendan has been studied in these patients with acute HF and is considered experimental in the United States for this population.
Primary Outcome
Left ventricular end-diastolic pressure (LVEDP) recorded from CD Leycom ConductNT software analysis.
Conditions Studied
Interventions
- DRUG levosimendan
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2006-09 |
| Est. Completion | 2008-12 |
| Phase | Phase 2 |
What the finished NCT00585104 record still lists
NCT00585104 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which levosimendan is the first listed.
NCT00585104 reports a single indexed study location in Utah.
Frequently Asked Questions
What is clinical trial NCT00585104 about?
NCT00585104 is a clinical study titled "Myocardial Hemodynamic Effects of Levosimendan". This study will test the hypothesis that mechanical efficiency as measured by pressure-volume loop assessment should improve during short-term treatment with intravenous levosimendan. Levosimendan (SimdaxTM, Abbott Laboratories, Abbott Park, IL) is a calcium sensitizer which has been shown to have ...
What is the current status of trial NCT00585104?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2006-09. Estimated completion is 2008-12.
What conditions does trial NCT00585104 study?
This clinical trial studies the following conditions: Heart Failure.
What interventions are being tested in trial NCT00585104?
The interventions under investigation include: levosimendan (DRUG).
Who is sponsoring clinical trial NCT00585104?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00585104 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00585104's enrollment target sits among peer trials
10 383rd of 397 higher than 7 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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