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NCT00776035 · ClinicalTrials.gov registry record
Sex and Obesity: Effects on Heart Failure Study
A clinical trial of Obesity and Heart Failure, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- 19
- Enrollment target
- 1
- Study location
NCT00776035: Completed study of Obesity and Heart Failure, sponsored by Washington University School of Medicine.
NCT00776035 is a study of Obesity and Heart Failure that has completed, run by Washington University School of Medicine. The registered enrollment target is 19 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00776035, a study of Obesity and Heart Failure, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- 19 participants
- Enrollment target
- 1
- Study location
Study Summary
Sex has a major impact on myocardial metabolism and blood flow. In those without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow. Obesity is a major risk factor for Heart Failure. In those without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men. To measure blood flow and metabolism we used radioactive materials and a PET (positron emission Tomography) scan to study the blood flow and substrate metabolism of the heart. Hypotheses: 1) Women with heart failure with reduced ejection fraction (HFrEF) will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with HFrEF. A secondary Aim was to test the hypothesis that body mass index (BMI), a measure of obesity, correlated with myocardial blood flow and myocardial metabolism measures in patients with HFrEF.
Primary Outcome
Myocardial blood flow (MBF) was measured using \^15O-water injected intravenously intravenously through a large bore catheter into an antecubital vein during the (Positron Emission Tomography (PET) scan on Study Day 2.
Conditions Studied
Interventions
- PROCEDURE Echocardiogram
- PROCEDURE PET (Positron Emission Tomography)
- RADIATION ^15O-water
- RADIATION 1-^11C-palmitate
- RADIATION 1-^11C-glucose
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2000-02-01 |
| Est. Completion | 2011-04-02 |
What the finished NCT00776035 record still lists
NCT00776035 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which Echocardiogram is the first listed.
NCT00776035 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT00776035 about?
NCT00776035 is a clinical study titled "Sex and Obesity: Effects on Heart Failure Study". Sex has a major impact on myocardial metabolism and blood flow. In those without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow. Obesity is a major risk factor for Heart Failure. In those without heart failure, increasin...
What is the current status of trial NCT00776035?
This trial is currently completed. The enrollment target is 19 participants. The study started on 2000-02-01. Estimated completion is 2011-04-02.
What conditions does trial NCT00776035 study?
This clinical trial studies the following conditions: Obesity, Heart Failure.
What interventions are being tested in trial NCT00776035?
The interventions under investigation include: Echocardiogram (PROCEDURE), PET (Positron Emission Tomography) (PROCEDURE), ^15O-water (RADIATION), 1-^11C-palmitate (RADIATION), 1-^11C-glucose (RADIATION).
Who is sponsoring clinical trial NCT00776035?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00776035 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT00776035's enrollment target sits among peer trials
19 975th of 1053 higher than 73 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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