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NCT06623344 · ClinicalTrials.gov registry record · NA
Brain Volume and Cardiac Function in Heart Failure
A NA study of Heart Failure, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 2
- Study locations
NCT06623344: Recruiting NA study of Heart Failure, sponsored by Johns Hopkins University.
NCT06623344 is a NA study of Heart Failure that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 100 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (95% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06623344, a NA study of Heart Failure, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 2
- Study locations
Study Summary
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes. Indeed, lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke, dementia, or heart failure. A few prior studies have examined the subcortical structural differences in patients with HF compared to controls. Brain volume loss (including putamen and hippocampal volumes) have been reported in patients with low ejection fraction. Significant gray matter loss was found in specific brain regions of HF patients and included structures that serve demonstrated roles in cognitive functions. In the investigator's previous study (Comprehensive Imaging Exam of Convalesced COVID-19 Patients - COVID-19 RELATED SUBMISSION-IRB00252436), involving 100 participants (volunteers with normal heart function (ejection fraction; 50%)), the investigators observed significant correlations between thalamic volumes and ventricular stroke volumes in volunteers. Building on these findings, the investigators intend to expand the research to include individuals with heart failure (HF), employing the same MRI protocol. The study will involve obtaining a set of T1-weighted brain images to measure the volumes of seven subcortical structures. The investigators goal is to explore the relationship between subcortical volumes and cardiac parameters. Additionally, the investigators will examine whether patients with HF experience a more rapid reduction in subcortical volumes compared to those with normal cardiac function (EF;50%).
Primary Outcome
To access the correlation of cardiac structure and function to the subcortical volumes in patients with heart failure.
Conditions Studied
Interventions
- OTHER Magnetic Resonance Imaging with or without Contrast
Study Locations (2)
Maryland
- Johns Hopkins Center for Advanced Imaging and Research Science, Johns Hopkins Science + Technology Park at 1812 Ashland Avenue, Baltimore, MD - Baltimore
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-11-10 |
| Est. Completion | 2026-10-01 |
| Phase | NA |
What NCT06623344 shows while recruiting
NCT06623344 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which Magnetic Resonance Imaging with or without Contrast is the first listed.
NCT06623344 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06623344 about?
NCT06623344 is a clinical study titled "Brain Volume and Cardiac Function in Heart Failure". Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysi...
What is the current status of trial NCT06623344?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2024-11-10. Estimated completion is 2026-10-01.
What conditions does trial NCT06623344 study?
This clinical trial studies the following conditions: Heart Failure.
What interventions are being tested in trial NCT06623344?
The interventions under investigation include: Magnetic Resonance Imaging with or without Contrast (OTHER).
Who is sponsoring clinical trial NCT06623344?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06623344 being conducted?
This trial has 2 study locations across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06623344's enrollment target sits among peer trials
100 212th of 397 higher than 177 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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