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NCT05562167 · ClinicalTrials.gov registry record · Phase 2
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
A Phase 2 study of Heart Failure, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT05562167: Recruiting Phase 2 study of Heart Failure, sponsored by Washington University School of Medicine.
NCT05562167 is a Phase 2 study of Heart Failure that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 75 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05562167, a Phase 2 study of Heart Failure, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular ejection fraction \<45%). The investigators hypothesize that both acute and chronic dosing of 10mmol of KNO3 will improve exercise performance in HFrEF. To test this hypothesis, the investors will perform a randomized, double-blind, placebo-controlled, parallel-arm design study.
Primary Outcome
peak oxygen consumption during treadmill exercise
Conditions Studied
Interventions
- DRUG Placebo
- DRUG KNO3
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2023-03-31 |
| Est. Completion | 2027-07-31 |
| Phase | Phase 2 |
What NCT05562167 shows while recruiting
NCT05562167 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05562167 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT05562167 about?
NCT05562167 is a clinical study titled "The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)". The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular ...
What is the current status of trial NCT05562167?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2023-03-31. Estimated completion is 2027-07-31.
What conditions does trial NCT05562167 study?
This clinical trial studies the following conditions: Heart Failure.
What interventions are being tested in trial NCT05562167?
The interventions under investigation include: Placebo (DRUG), KNO3 (DRUG).
Who is sponsoring clinical trial NCT05562167?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05562167 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05562167's enrollment target sits among peer trials
75 233rd of 397 higher than 161 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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