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NCT05265520 · ClinicalTrials.gov registry record · NA
His-Bundle Corrective Pacing in Heart Failure
A NA study of Heart Failure and Cardiac Resynchronization Therapy, sponsored by University of Rochester.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 14
- Study locations
NCT05265520: Recruiting NA study of Heart Failure and Cardiac Resynchronization Therapy, sponsored by University of Rochester.
NCT05265520 is a NA study of Heart Failure and Cardiac Resynchronization Therapy that is actively recruiting participants, run by University of Rochester. The registered enrollment target is 120 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (94% lower). The trial reports 14 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05265520, a NA study of Heart Failure and Cardiac Resynchronization Therapy, is actively recruiting participants, sponsored by University of Rochester.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 14
- Study locations
Study Summary
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
Primary Outcome
The effect of His-CRT vs. BIV-CRT on left ventricular ejection fraction (as a percentage) measured during an echocardiography imaging study will be analyzed using an analysis of covariance model for changes in LVEF from pre-implantation (baseline) to post-implantation (6 months follow-up), with randomized treatment group as the factor of interest, and baseline LVEF as a covariate. A t-test will be performed using this model to compare the adjusted group means, and a confidence interval will be c
Conditions Studied
Interventions
- PROCEDURE His-CRT implantation
- PROCEDURE BIV-CRT implantation
Study Locations (14)
Illinois
- Northwestern Memorial Hospital - Chicago
- Rush University Medical Center - Chicago
- University of Chicago - Chicago
New York
- Weill Cornell Medical College - New York
- Mount Sinai Hospital - New York
Pennsylvania
- University of Pennsylvania - Philadelphia
- Geisinger Wyoming Valley - Wilkes-Barre
Arizona
- University of Arizona - Phoenix
California
- Cedars-Sinai Medical Center - Los Angeles
Florida
- University of South Florida - Tampa
New Jersey
- Valley Health System - Ridgewood
North Carolina
- Mission Health - Asheville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2022-12-02 |
| Est. Completion | 2028-07-01 |
| Phase | NA |
What NCT05265520 shows while recruiting
NCT05265520 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (94% lower).
The record links to 4 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which His-CRT implantation is the first listed.
NCT05265520 lists 14 locations in 10 states (Illinois, New York, Pennsylvania).
Frequently Asked Questions
What is clinical trial NCT05265520 about?
NCT05265520 is a clinical study titled "His-Bundle Corrective Pacing in Heart Failure". The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
What is the current status of trial NCT05265520?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2022-12-02. Estimated completion is 2028-07-01.
What conditions does trial NCT05265520 study?
This clinical trial studies the following conditions: Heart Failure, Cardiac Resynchronization Therapy, Right Bundle-Branch Block, His-bundle Pacing.
What interventions are being tested in trial NCT05265520?
The interventions under investigation include: His-CRT implantation (PROCEDURE), BIV-CRT implantation (PROCEDURE).
Who is sponsoring clinical trial NCT05265520?
This trial is sponsored by University of Rochester, which has 636 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05265520 being conducted?
This trial has 14 study locations across Arizona, California, Florida, Illinois, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05265520's enrollment target sits among peer trials
120 202nd of 397 higher than 194 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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