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NCT05318105 · ClinicalTrials.gov registry record · NA
Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
A NA study of Heart Failure and Fluid Overload, sponsored by Nuwellis.
- Recruiting
- Registry status
- NA
- Development phase
- 372
- Enrollment target
- 17
- Study locations
NCT05318105 is a NA study of Heart Failure and Fluid Overload that is actively recruiting participants, run by Nuwellis. The registered enrollment target is 372 participants, below the 2,048-participant average among 397 other Heart Failure trials with a reported enrollment target (82% lower). The trial reports 17 study locations across 11 states.
The verdict
NCT05318105, a NA study of Heart Failure and Fluid Overload, is actively recruiting participants, sponsored by Nuwellis.
- RECRUITING
- Registry status
- NA
- Development phase
- 372 participants
- Enrollment target
- 17
- Study locations
Study Summary
The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop diuretics in patients with worsening heart failure (HF) and fluid overload.
Conditions Studied
Interventions
- DEVICE Aquadex Smartflow® System
- DRUG IV Loop Diuretics
Study Locations (17)
California
- MemorialCare, Long Beach Medical Center - Long Beach
- Sharp Memorial Hospital, San Diego Cardiac Center - San Diego
- University of California San Francisco - San Francisco
New York
- Mount Sinai Morningside - New York
- The Mount Sinai Hospital - New York
- Northwell Health - New York
Florida
- BayCare Medical Group, Morton Plant - Clearwater
- St. Joseph's Hospital - Tampa
Ohio
- The Christ Hospital - Cincinnati
- The Ohio State University - Columbus
Arizona
- Banner Health - Tucson
Kentucky
- University of Kentucky - Lexington
Michigan
- Henry Ford Health - Detroit
Pennsylvania
- Abington Jefferson Health - Abington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 372 participants |
| Start Date | 2022-06-28 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05318105
The ClinicalTrials.gov registry entry for NCT05318105 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 372 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,048-participant average among 397 other Heart Failure trials with a reported enrollment target (82% lower). The listed sponsor is Nuwellis, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Aquadex Smartflow® System is the first listed.
NCT05318105 reports 17 study locations spanning 11 distinct geographic areas - top geographies include California, New York, Florida.
Frequently Asked Questions
What is clinical trial NCT05318105 about?
NCT05318105 is a clinical study titled "Ultrafiltration Versus IV Diuretics in Worsening Heart Failure". The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop diuretics in patients with worsening heart failure (HF) and fluid overload.
What is the current status of trial NCT05318105?
This trial is currently recruiting. It is a NA study. The enrollment target is 372 participants. The study started on 2022-06-28. Estimated completion is 2026-12-31.
What conditions does trial NCT05318105 study?
This clinical trial studies the following conditions: Heart Failure, Fluid Overload, Heart Failure (for Example, Fluid Overload).
What interventions are being tested in trial NCT05318105?
The interventions under investigation include: Aquadex Smartflow® System (DEVICE), IV Loop Diuretics (DRUG).
Who is sponsoring clinical trial NCT05318105?
This trial is sponsored by Nuwellis, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05318105 being conducted?
This trial has 17 study locations across Arizona, California, Florida, Kentucky, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.