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NCT02973633 · ClinicalTrials.gov registry record · Early Phase 1
Diffusion MRI in Heart Failure
A Early Phase 1 study of Heart Failure and Myocardial Infarction, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT02973633 is a Early Phase 1 study of Heart Failure and Myocardial Infarction that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 160 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.
The verdict
NCT02973633, a Early Phase 1 study of Heart Failure and Myocardial Infarction, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart failure and the transition from a compensated to a decompensated state. Patients with recent myocardial infarcts and left ventricular hypertrophy, who are at risk for the development of heart failure, will be enrolled. The participants will undergo serial diffusion tensor MRI (DTI) imaging of the heart to characterize changes in myocardial microstructure over time.
Conditions Studied
Interventions
- DEVICE Diffusion Tensor MRI (DTI)
- DRUG Gadolinium DOTA Meglumine
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2017-06-30 |
| Est. Completion | 2028-12-31 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02973633
The ClinicalTrials.gov registry entry for NCT02973633 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (92% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Diffusion Tensor MRI (DTI) is the first listed.
NCT02973633 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02973633 about?
NCT02973633 is a clinical study titled "Diffusion MRI in Heart Failure". The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with ...
What is the current status of trial NCT02973633?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 160 participants. The study started on 2017-06-30. Estimated completion is 2028-12-31.
What conditions does trial NCT02973633 study?
This clinical trial studies the following conditions: Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy.
What interventions are being tested in trial NCT02973633?
The interventions under investigation include: Diffusion Tensor MRI (DTI) (DEVICE), Gadolinium DOTA Meglumine (DRUG).
Who is sponsoring clinical trial NCT02973633?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02973633 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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