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NCT02973633 · ClinicalTrials.gov registry record · Early Phase 1
Diffusion MRI in Heart Failure
A Early Phase 1 study of Heart Failure and Myocardial Infarction, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT02973633: Recruiting Early Phase 1 study of Heart Failure and Myocardial Infarction, sponsored by Massachusetts General Hospital.
NCT02973633 is a Early Phase 1 study of Heart Failure and Myocardial Infarction that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 160 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02973633, a Early Phase 1 study of Heart Failure and Myocardial Infarction, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart failure and the transition from a compensated to a decompensated state. Patients with recent myocardial infarcts and left ventricular hypertrophy, who are at risk for the development of heart failure, will be enrolled. The participants will undergo serial diffusion tensor MRI (DTI) imaging of the heart to characterize changes in myocardial microstructure over time.
Primary Outcome
The investigators aim to determine how the myofibers in the heart change their orientation in heart disease by measuring their helix angle.
Conditions Studied
Interventions
- DEVICE Diffusion Tensor MRI (DTI)
- DRUG Gadolinium DOTA Meglumine
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2017-06-30 |
| Est. Completion | 2028-12-31 |
| Phase | Early Phase 1 |
What NCT02973633 shows while recruiting
NCT02973633 is an interventional study that assigns participants to a tested intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (92% lower).
The record links to 3 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Diffusion Tensor MRI (DTI) is the first listed.
NCT02973633 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02973633 about?
NCT02973633 is a clinical study titled "Diffusion MRI in Heart Failure". The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with ...
What is the current status of trial NCT02973633?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 160 participants. The study started on 2017-06-30. Estimated completion is 2028-12-31.
What conditions does trial NCT02973633 study?
This clinical trial studies the following conditions: Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy.
What interventions are being tested in trial NCT02973633?
The interventions under investigation include: Diffusion Tensor MRI (DTI) (DEVICE), Gadolinium DOTA Meglumine (DRUG).
Who is sponsoring clinical trial NCT02973633?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02973633 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02973633's enrollment target sits among peer trials
160 185th of 397 higher than 212 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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