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NCT06274749 · ClinicalTrials.gov registry record · NA

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial

A NA study of Healthy Volunteer, sponsored by National Institute on Aging (NIA).

Recruiting
Registry status
NA
Development phase
180
Enrollment target
1
Study location

NCT06274749 is a NA study of Healthy Volunteer that is actively recruiting participants, run by National Institute on Aging (NIA). The registered enrollment target is 180 participants, below the 200-participant average among 112 other Healthy Volunteer trials with a reported enrollment target (10% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06274749, a NA study of Healthy Volunteer, is actively recruiting participants, sponsored by National Institute on Aging (NIA).

RECRUITING
Registry status
NA
Development phase
180 participants
Enrollment target
1
Study location

Study Summary

Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as diabetes. Urolithin A (UA) is a natural nutritional supplement that may improve how the body controls blood glucose. Objective: To learn if UA improves levels of insulin and other hormones that help control blood glucose. Eligibility: People aged 55 years and older with a body mass index of 27 or higher. Design: Participants will have 6 clinic visits over 8 weeks. Participants will be screened. They will have a physical exam with blood and urine tests and a test of their heart function. UA gelcaps are taken by mouth every morning at home. Half of participants will take UA. The other half will take a placebo. The placebo looks like the study drug but does not contain any medicine. Participants will not know which they are taking. Participants will have tests during the study including: Oral glucose tolerance: Participants will drink a sweet liquid. Blood will be drawn at intervals over the next 3 hours. Continuous glucose monitor: A sensor with a needle that goes just under the skin will be placed on the upper arm. Participants will wear this sensor throughout the study. Exercise. Participants will walk on a treadmill while their heart rate, hearth rhythm, and blood pressure are monitored. They will walk in a hallway at normal and fast paces. Imaging scans of the thigh; scans of the brain are optional....

Conditions Studied

Healthy Volunteer

Interventions

  • DIETARY_SUPPLEMENT Placebo
  • DIETARY_SUPPLEMENT Urolithin A

Study Locations (1)

Maryland

  • National Institute of Aging, Clinical Research Unit - Baltimore

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2026-03-26
Est. Completion 2027-03-31
Phase NA

Sponsor

National Institute on Aging (NIA)

131 total trials

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What the Registry Record Tells You About NCT06274749

The ClinicalTrials.gov registry entry for NCT06274749 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 200-participant average among 112 other Healthy Volunteer trials with a reported enrollment target (10% lower). The listed sponsor is National Institute on Aging (NIA), which has 131 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Healthy Volunteer appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06274749 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT06274749 about?

NCT06274749 is a clinical study titled "Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial". Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as diabetes. Urolithin A (UA) is a natural nutritional supplement that may improve how the body controls blood g...

What is the current status of trial NCT06274749?

This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2026-03-26. Estimated completion is 2027-03-31.

What conditions does trial NCT06274749 study?

This clinical trial studies the following conditions: Healthy Volunteer.

What interventions are being tested in trial NCT06274749?

The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Urolithin A (DIETARY_SUPPLEMENT).

Who is sponsoring clinical trial NCT06274749?

This trial is sponsored by National Institute on Aging (NIA), which has 131 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06274749 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.