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Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
NCT06989320 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will ingest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Low-oxalate diet and glycolate dosing
- DIETARY_SUPPLEMENT Oral glycolate dosing
- DIETARY_SUPPLEMENT Oral 13C- ascorbic acid dosing
Study Locations (2)
Alabama
- United States, Alabama University of Alabama at Birmingham — Birmingham
Texas
- University of Texas South Western Medical Center — Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-05-27 |
| Est. Completion | 2031-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06989320
The ClinicalTrials.gov registry entry for NCT06989320 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Alabama at Birmingham, which has 1,315 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 9 conditions, with Healthy appearing as the primary indexed condition, and to 3 interventions — of which Low-oxalate diet and glycolate dosing is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06989320 reports 2 study locations spanning 2 distinct geographic areas — top geographies include Alabama, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06989320 about?
NCT06989320 is a clinical study titled "Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease". The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney ...
What is the current status of trial NCT06989320?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2025-05-27. Estimated completion is 2031-12-31.
What conditions does trial NCT06989320 study?
This clinical trial studies the following conditions: Healthy, Healthy Volunteer, Nephrolithiasis, Kidney Stones, Urolithiasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06989320?
The interventions under investigation include: Low-oxalate diet and glycolate dosing (DIETARY_SUPPLEMENT), Oral glycolate dosing (DIETARY_SUPPLEMENT), Oral 13C- ascorbic acid dosing (DIETARY_SUPPLEMENT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06989320?
This trial is sponsored by University of Alabama at Birmingham, which has 1,315 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06989320 being conducted?
This trial has 2 study locations across Alabama, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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