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Pentostatin in Treating Patients With Refractory Chronic Graft-Versus-Host Disease
NCT00074035 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Pentostatin may be effective in treating chronic graft-versus-host disease by stopping the immune system from rejecting donor stem cells or donor white blood cells. PURPOSE: This phase II trial is studying how well pentostatin works in treating patients with chronic graft-versus-host disease that is refractory (not responsive) to treatment with steroids.
Conditions Studied
Interventions
- DRUG pentostatin
Study Locations (16)
Pennsylvania
- Abramson Cancer Center of the University of Pennsylvania — Philadelphia
- Fox Chase Cancer Center - Philadelphia — Philadelphia
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital — Pittsburgh
Delaware
- Tunnell Cancer Center at Beebe Medical Center — Lewes
- CCOP - Christiana Care Health Services — Newark
Illinois
- University of Illinois Cancer Center — Chicago
- University of Chicago Cancer Research Center — Chicago
Maryland
- Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore
- Union Hospital Cancer Program at Union Hospital — Elkton
North Carolina
- Duke Comprehensive Cancer Center — Durham
- Wake Forest University Comprehensive Cancer Center — Winston-Salem
Minnesota
- Mayo Clinic Cancer Center — Rochester
New Jersey
- Cancer Institute of New Jersey at Cooper - Voorhees — Voorhees Township
New York
- New York Weill Cornell Cancer Center at Cornell University — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 39 participants |
| Start Date | 2003-12 |
| Est. Completion | 2014-11-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00074035
The ClinicalTrials.gov registry entry for NCT00074035 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 39 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Graft Versus Host Disease appearing as the primary indexed condition, and to 1 intervention — of which pentostatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00074035 reports 16 study locations spanning 10 distinct geographic areas — top geographies include Pennsylvania, Delaware, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00074035 about?
NCT00074035 is a clinical study titled "Pentostatin in Treating Patients With Refractory Chronic Graft-Versus-Host Disease". RATIONALE: Pentostatin may be effective in treating chronic graft-versus-host disease by stopping the immune system from rejecting donor stem cells or donor white blood cells. PURPOSE: This phase II trial is studying how well pentostatin works in treating patients with chronic graft-versus-host dis...
What is the current status of trial NCT00074035?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 39 participants. The study started on 2003-12. Estimated completion is 2014-11-01.
What conditions does trial NCT00074035 study?
This clinical trial studies the following conditions: Graft Versus Host Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00074035?
The interventions under investigation include: pentostatin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00074035?
This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00074035 being conducted?
This trial has 16 study locations across Delaware, Illinois, Maryland, Minnesota, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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