Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06392711 · ClinicalTrials.gov registry record · Phase 1
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
A Phase 1 study of Graft-Versus-Host Disease and Xerostomia, sponsored by University of Wisconsin, Madison.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
- 1
- Study location
NCT06392711 is a Phase 1 study of Graft-Versus-Host Disease and Xerostomia that is actively recruiting participants, run by University of Wisconsin, Madison. The registered enrollment target is 36 participants, below the 82-participant average among 38 other Graft-Versus-Host Disease trials with a reported enrollment target (56% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06392711, a Phase 1 study of Graft-Versus-Host Disease and Xerostomia, is actively recruiting participants, sponsored by University of Wisconsin, Madison.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands. The main question it aims to answer is whether injection of MSCs into salivary glands results in any improvement in dry mouth. Participants will: * have bone marrow collected using a needle * undergo a salivary gland ultrasound * complete questionnaires * receive an injection of the bone marrow cells into a salivary gland
Conditions Studied
Interventions
- BIOLOGICAL Mesenchymal Stromal Cells (MSC) Dose Level 0
- BIOLOGICAL Mesenchymal Stromal Cells (MSC) Dose Level 1
Study Locations (1)
Wisconsin
- University of Wisconsin - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2024-10-04 |
| Est. Completion | 2028-11 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06392711
The ClinicalTrials.gov registry entry for NCT06392711 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 82-participant average among 38 other Graft-Versus-Host Disease trials with a reported enrollment target (56% lower). The listed sponsor is University of Wisconsin, Madison, which has 1,039 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Graft-Versus-Host Disease appearing as the primary indexed condition, and to 2 interventions - of which Mesenchymal Stromal Cells (MSC) Dose Level 0 is the first listed.
NCT06392711 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.
Frequently Asked Questions
What is clinical trial NCT06392711 about?
NCT06392711 is a clinical study titled "Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia". The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands. The main question it aims to answer is whether injection of MSCs into salivary glands results in any improvement...
What is the current status of trial NCT06392711?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2024-10-04. Estimated completion is 2028-11.
What conditions does trial NCT06392711 study?
This clinical trial studies the following conditions: Graft-Versus-Host Disease, Xerostomia, Sjogrens Disease.
What interventions are being tested in trial NCT06392711?
The interventions under investigation include: Mesenchymal Stromal Cells (MSC) Dose Level 0 (BIOLOGICAL), Mesenchymal Stromal Cells (MSC) Dose Level 1 (BIOLOGICAL).
Who is sponsoring clinical trial NCT06392711?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06392711 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Graft-Versus-Host Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis
RECRUITING · Phase 1
-
Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
RECRUITING · Phase 1
-
Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant
ACTIVE NOT RECRUITING · Phase 1
-
Optimizing PTCy Dose and Timing
ACTIVE NOT RECRUITING · Phase 1
-
Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD)
ACTIVE NOT RECRUITING · Phase 1
-
Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation
COMPLETED · Phase 1
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.