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NCT03180502 · ClinicalTrials.gov registry record · Phase 2
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
A Phase 2 study of Glioma and Anaplastic Astrocytoma, sponsored by NRG Oncology.
- Active
- Registry status
- Phase 2
- Development phase
- 120
- Enrollment target
- 20
- Study locations
NCT03180502: Active Phase 2 study of Glioma and Anaplastic Astrocytoma, sponsored by NRG Oncology.
NCT03180502 is a Phase 2 study of Glioma and Anaplastic Astrocytoma that is active but no longer recruiting, run by NRG Oncology. The registered enrollment target is 120 participants, below the 209-participant average among 87 other Glioma trials with a reported enrollment target (43% lower). The trial reports 20 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03180502, a Phase 2 study of Glioma and Anaplastic Astrocytoma, is active but no longer recruiting, sponsored by NRG Oncology.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 120 participants
- Enrollment target
- 20
- Study locations
Study Summary
This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation directly to the tumor and may cause less damage to normal tissue. Intensity-modulated or photon beam radiation therapy uses high-energy x-ray beams shaped to treat the tumor and may also cause less damage to normal tissue. It is not yet known if proton beam radiation therapy is more effective than photon-based beam intensity-modulated radiation therapy in treating patients with glioma.
Primary Outcome
Assessed with a general linear model with maximum likelihood estimation. Three models will be conducted. Baseline CTB COMP score, treatment arm, time, treatment by time interaction (if significant) and stratification factors will be included in the model for the primary endpoint. A second model will be built with these same variables and relevant covariates, such as total volume of intracranial disease, gross tumor volume (GTV) and clinical tumor volume (CTV) size, histology, anti-epileptic use,
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Magnetic Resonance Imaging
- OTHER Laboratory Biomarker Analysis
- RADIATION Intensity-Modulated Radiation Therapy
- RADIATION Proton Beam Radiation Therapy
Study Locations (20)
Maryland
- Maryland Proton Treatment Center - Baltimore
- University of Maryland/Greenebaum Cancer Center - Baltimore
- UM Upper Chesapeake Medical Center - Bel Air
- Central Maryland Radiation Oncology in Howard County - Columbia
- UM Baltimore Washington Medical Center/Tate Cancer Center - Glen Burnie
Georgia
- Emory Proton Therapy Center - Atlanta
- Emory University Hospital Midtown - Atlanta
- Emory University Hospital/Winship Cancer Institute - Atlanta
Illinois
- Northwestern University - Chicago
- Northwestern Medicine Cancer Center Delnor - Geneva
- Northwestern Medicine Cancer Center Warrenville - Warrenville
Kansas
- University of Kansas Cancer Center - Kansas City
- University of Kansas Cancer Center-Overland Park - Overland Park
- University of Kansas Hospital-Westwood Cancer Center - Westwood
Florida
- Boca Raton Regional Hospital - Boca Raton
- Miami Cancer Institute - Miami
Alabama
- University of Alabama at Birmingham Cancer Center - Birmingham
Maine
- MaineHealth Maine Medical Center- Scarborough - Scarborough
Massachusetts
- Massachusetts General Hospital Cancer Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2018-01-23 |
| Est. Completion | 2027-06-01 |
| Phase | Phase 2 |
What the registry record for NCT03180502 still lists
NCT03180502 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 209-participant average among 87 other Glioma trials with a reported enrollment target (43% lower).
The record links to 8 conditions, with Glioma appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT03180502 names 20 study sites across 9 states, led by Maryland, Georgia, Illinois.
Frequently Asked Questions
What is clinical trial NCT03180502 about?
NCT03180502 is a clinical study titled "Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma". This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation dir...
What is the current status of trial NCT03180502?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2018-01-23. Estimated completion is 2027-06-01.
What conditions does trial NCT03180502 study?
This clinical trial studies the following conditions: Glioma, Anaplastic Astrocytoma, Oligodendroglioma, Anaplastic Oligodendroglioma, WHO Grade 3 Glioma.
What interventions are being tested in trial NCT03180502?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Magnetic Resonance Imaging (PROCEDURE), Laboratory Biomarker Analysis (OTHER), Intensity-Modulated Radiation Therapy (RADIATION), Proton Beam Radiation Therapy (RADIATION).
Who is sponsoring clinical trial NCT03180502?
This trial is sponsored by NRG Oncology, which has 64 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03180502 being conducted?
This trial has 20 study locations across Alabama, Florida, Georgia, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glioma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03180502's enrollment target sits among peer trials
120 17th of 87 higher than 70 of 87 other Glioma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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