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NCT03514069 · ClinicalTrials.gov registry record · Phase 1
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
A Phase 1 study of Glioblastoma and Glioma, sponsored by Case Comprehensive Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT03514069: Active Phase 1 study of Glioblastoma and Glioma, sponsored by Case Comprehensive Cancer Center.
NCT03514069 is a Phase 1 study of Glioblastoma and Glioma that is active but no longer recruiting, run by Case Comprehensive Cancer Center. The registered enrollment target is 60 participants, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (45% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03514069, a Phase 1 study of Glioblastoma and Glioma, is active but no longer recruiting, sponsored by Case Comprehensive Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard treatment for brain cancer, temozolomide and radiation. Ruxolitinib is an experimental drug that works by targeting proteins in cells and stops them from growing. Ruxolitinib is experimental because it is not approved by the Food and Drug Administration (FDA) for the treatment of gliomas or glioblastomas Temozolomide works by damaging the DNA of tumor cells so that they cannot divide properly. Some tumor cells can repair that damage and therefore be resistant to temozolomide.
Conditions Studied
Interventions
- DRUG temozolomide
- DRUG ruxolitinib
- RADIATION radiation
Study Locations (1)
Ohio
- Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2018-06-05 |
| Est. Completion | 2026-05-31 |
| Phase | Phase 1 |
What the registry record for NCT03514069 still lists
NCT03514069 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (45% lower).
The record links to 2 conditions, with Glioblastoma appearing as the primary indexed condition, and to 3 interventions - of which temozolomide is the first listed.
NCT03514069 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03514069 about?
NCT03514069 is a clinical study titled "Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma". The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard treatment for brain cancer, temozolomide and radiation. Ruxolitinib is an experimental drug that works by tar...
What is the current status of trial NCT03514069?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2018-06-05. Estimated completion is 2026-05-31.
What conditions does trial NCT03514069 study?
This clinical trial studies the following conditions: Glioblastoma, Glioma.
What interventions are being tested in trial NCT03514069?
The interventions under investigation include: temozolomide (DRUG), ruxolitinib (DRUG), radiation (RADIATION).
Who is sponsoring clinical trial NCT03514069?
This trial is sponsored by Case Comprehensive Cancer Center, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03514069 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glioblastoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03514069's enrollment target sits among peer trials
60 75th of 199 higher than 122 of 199 other Glioblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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