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RECRUITING Phase 2

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

NCT03970447 · View on ClinicalTrials.gov ↗

Study Summary

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.

Conditions Studied

Interventions

  • DRUG Temozolomide
  • DRUG Regorafenib
  • RADIATION Radiation
  • DRUG Lomustine
  • DRUG Paxalisib

Study Locations (20)

California

  • University of California, San Diego — La Jolla
  • Cedars Sinai - Samuel Oschin Comprehensive Cancer Institute — Los Angeles
  • University of California, Los Angeles — Los Angeles
  • St. Joseph Hospital — Orange
  • University of California, San Francisco — San Francisco
  • Stanford Cancer Center — Stanford

Florida

  • Mayo Clinic Cancer Center — Jacksonville
  • Sylvester Comprehensive Cancer Center — Miami
  • Moffitt Cancer Center — Tampa

Georgia

  • Piedmont Atlanta Hospital — Atlanta
  • Winship Cancer Institute of Emory University — Atlanta

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana Farber Cancer Institute — Boston

Minnesota

  • Abbott Northwestern Hospital — Minneapolis
  • Mayo Clinic Cancer Center - Rochester — Rochester

Alabama

  • University of Alabama at Birmingham — Birmingham

Colorado

  • University of Colorado Denver — Aurora

Connecticut

  • Yale Cancer Center / Smilow Cancer Hospital — New Haven

Trial Details

FieldValue
Enrollment Target 1,280 participants
Start Date 2019-07-30
Est. Completion 2030-06
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03970447

The ClinicalTrials.gov registry entry for NCT03970447 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,280 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Global Coalition for Adaptive Research, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Glioblastoma appearing as the primary indexed condition, and to 5 interventions — of which Temozolomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03970447 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03970447 about?

NCT03970447 is a clinical study titled "A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma". Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.

What is the current status of trial NCT03970447?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 1,280 participants. The study started on 2019-07-30. Estimated completion is 2030-06.

What conditions does trial NCT03970447 study?

This clinical trial studies the following conditions: Glioblastoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03970447?

The interventions under investigation include: Temozolomide (DRUG), Regorafenib (DRUG), Radiation (RADIATION), Lomustine (DRUG), Paxalisib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03970447?

This trial is sponsored by Global Coalition for Adaptive Research, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03970447 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial