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NCT03746769 · ClinicalTrials.gov registry record · Phase 1
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
A Phase 1 study of Diabetes Mellitus, Type 1, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT03746769: Recruiting Phase 1 study of Diabetes Mellitus, Type 1, sponsored by City of Hope Medical Center.
NCT03746769 is a Phase 1 study of Diabetes Mellitus, Type 1 that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 20 participants, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03746769, a Phase 1 study of Diabetes Mellitus, Type 1, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control. This study involves two investigational (experimental) products not yet approved by the U.S. Food and Drug Administration (FDA) as a treatment for any disease: 1. Human allogenic islet cells (islet cells from a deceased, unrelated human donor) 2. Gastrin-17 (Gastrin) - a hormone secreted by the gut
Conditions Studied
Interventions
- BIOLOGICAL Allogenic Human Islet Cells
- DRUG Gastrin 17
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2019-07-07 |
| Est. Completion | 2028-08-01 |
| Phase | Phase 1 |
What NCT03746769 shows while recruiting
NCT03746769 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Diabetes Mellitus, Type 1 appearing as the primary indexed condition, and to 2 interventions - of which Allogenic Human Islet Cells is the first listed.
NCT03746769 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03746769 about?
NCT03746769 is a clinical study titled "Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes". This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control. This study involves two investigational (experimental) products not yet appro...
What is the current status of trial NCT03746769?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2019-07-07. Estimated completion is 2028-08-01.
What conditions does trial NCT03746769 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 1.
What interventions are being tested in trial NCT03746769?
The interventions under investigation include: Allogenic Human Islet Cells (BIOLOGICAL), Gastrin 17 (DRUG).
Who is sponsoring clinical trial NCT03746769?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03746769 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetes Mellitus, Type 1
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03746769's enrollment target sits among peer trials
20 96th of 118 higher than 16 of 118 other Diabetes Mellitus, Type 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes Mellitus, Type 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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