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Diabetes Mellitus, Type 1 clinical trials
39 of 119 indexed Diabetes Mellitus, Type 1 trials are currently recruiting.
119 US clinical trials · 39 currently recruiting
Diabetes Mellitus, Type 1 is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 31 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 11 of these trials.
The research picture
Diabetes Mellitus, Type 1 has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.
- 39
- recruiting participants now
- 33%
- of trials open to enrollment
- 31
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
119 total, page 2 of 3
Family-Based Treatment for Type 1 Diabetes
State University of New York at Buffalo
NCT05756361
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
Sanofi
NCT05757713
The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes
Novo Nordisk A/S
NCT01836523
The Loop Observational Study
Jaeb Center for Health Research
NCT03838900
Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes
Novo Nordisk A/S
NCT02500706
Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)
Boehringer Ingelheim
NCT02414958
Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes
Novo Nordisk A/S
NCT00982228
A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)
Novo Nordisk A/S
NCT04848480
Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes
Novo Nordisk A/S
NCT00978627
A Study in Adults With Type 1 Diabetes
Eli Lilly and Company
NCT01421147
NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes
Novo Nordisk A/S
NCT00095446
Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes
Eli Lilly and Company
NCT00356109
Mylan Insulin Aspart Study
Mylan
NCT03760068
Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes
Eli Lilly and Company
NCT00127634
A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus
Novo Nordisk A/S
NCT01835431
Patient and Parent Preferences for an On-Body Automated Insulin Delivery System
Joslin Diabetes Center
NCT03534544
Afrezza® INHALE-1 Study in Pediatrics
Mannkind Corporation
NCT04974528
Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control
AstraZeneca
NCT00042458
Effect of Insulin Glulisine Compared to Insulin Aspart and Insulin Lispro When Administered by Continuous Subcutaneous Insulin Infusion (CSII) on Specific Pump Parameters in Patient With Type 1 Diabetes Mellitus
Sanofi
NCT00607087
Post Approval Study of the Eversense® Continuous Glucose Monitoring
Senseonics
NCT03908125
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
Becton, Dickinson and Company
NCT00741390
Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in Diabetics
Novo Nordisk A/S
NCT00773279
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
Duke University
NCT03938324
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
Scripps Whittier Diabetes Institute
NCT03068273
Day and Night Closed-loop in Young People With Type 1 Diabetes
Jaeb Center for Health Research
NCT02925299
Pilot Study of Brief Intervention to Support Diabetes Health-Related Quality of Life
Baylor College of Medicine
NCT05234944
Evaluation of TTP399 in Patients With Type 1 Diabetes
vTv Therapeutics
NCT03335371
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00406458
Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial
Tandem Diabetes Care
NCT03195140
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00476931
Clinical Startup of the 670G Closed Loop Insulin Delivery System
Stanford University
NCT03017482
Assessment of Mealtime Bolus Insulin Behavior
Eli Lilly and Company
NCT03368807
Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults
Eli Lilly and Company
NCT01994746
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00813228
Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index
University of Virginia
NCT02663661
Diabetes Visual Function Supplement Study
ZeaVision
NCT01646047
ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)
University of North Carolina, Chapel Hill
NCT03651622
Comparison of Glycemic Control Achieved With 2 Different Needles
Novo Nordisk A/S
NCT00572052
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
University of Colorado, Denver
NCT03618420
Green Digital Diabetes Waste Project
Florida State University
NCT06071325
Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus
Halozyme Therapeutics
NCT00883558
A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas
Massachusetts General Hospital
NCT02092220
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)
University of Minnesota
NCT03410277
Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control
Diasome Pharmaceuticals
NCT03096392
Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus
University of Virginia
NCT00943787
Pilot Study of Connected Diabetes Technology
University of California, Davis
NCT04106440
A Trial Evaluating Compatibility and Safety of FIAsp and Insulin Aspart With an External Continuous Subcutaneous Insulin Infusion System in Adult Subjects With Type 1 Diabetes
Novo Nordisk A/S
NCT01999322
A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes
Pfizer
NCT02038764
Medtronic Minimed Overnight Closed-Loop System
Bruce A. Buckingham
NCT01881009
Diabetes Assistant (DiAs) Control-to-Range (CTR) Nocturnal Closed-Loop Camp Study
University of Virginia
NCT01973413
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 14 |
| Phase 3 | 23 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 1 Trial Landscape
119 indexed Diabetes Mellitus, Type 1 studies · 39 recruiting (33%).
Phase mix: 31 late (III/IV) vs 27 early (I/II).
Top sponsor: Novo Nordisk A/S (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 1?
PlainTrial tracks 119 US clinical trials for Diabetes Mellitus, Type 1, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 1?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.