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ClinicalTrials.gov 39 recruiting now official registry

Diabetes Mellitus, Type 1 clinical trials

39 of 119 indexed Diabetes Mellitus, Type 1 trials are currently recruiting.

119 US clinical trials · 39 currently recruiting

Diabetes Mellitus, Type 1 is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 31 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 11 of these trials.

The research picture

Diabetes Mellitus, Type 1 has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.

39
recruiting participants now
33%
of trials open to enrollment
31
in Phase 3–4 (later-stage)
11
top sponsor: Novo Nordisk A/S
Phase 113Phase 214Phase 323Phase 48

Active & Recent Trials

119 total, page 2 of 3

ACTIVE NOT RECRUITING NA 20 participants

Family-Based Treatment for Type 1 Diabetes

State University of New York at Buffalo

NCT05756361

ACTIVE NOT RECRUITING Phase 4 20 participants

Teplizumab in Pediatric Stage 2 Type 1 Diabetes

Sanofi

NCT05757713

COMPLETED Phase 3 1,398 participants

The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes

Novo Nordisk A/S

NCT01836523

COMPLETED 1,212 participants

The Loop Observational Study

Jaeb Center for Health Research

NCT03838900

COMPLETED Phase 3 1,108 participants

Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT02500706

COMPLETED Phase 3 730 participants

Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)

Boehringer Ingelheim

NCT02414958

COMPLETED Phase 3 629 participants

Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00982228

COMPLETED Phase 3 582 participants

A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)

Novo Nordisk A/S

NCT04848480

COMPLETED Phase 3 548 participants

Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00978627

COMPLETED Phase 3 536 participants

A Study in Adults With Type 1 Diabetes

Eli Lilly and Company

NCT01421147

COMPLETED Phase 4 513 participants

NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes

Novo Nordisk A/S

NCT00095446

COMPLETED Phase 3 494 participants

Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes

Eli Lilly and Company

NCT00356109

COMPLETED Phase 3 478 participants

Mylan Insulin Aspart Study

Mylan

NCT03760068

COMPLETED Phase 3 385 participants

Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes

Eli Lilly and Company

NCT00127634

COMPLETED Phase 3 362 participants

A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT01835431

COMPLETED 362 participants

Patient and Parent Preferences for an On-Body Automated Insulin Delivery System

Joslin Diabetes Center

NCT03534544

COMPLETED Phase 3 319 participants

Afrezza® INHALE-1 Study in Pediatrics

Mannkind Corporation

NCT04974528

COMPLETED Phase 3 296 participants

Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control

AstraZeneca

NCT00042458

COMPLETED Phase 4 289 participants

Effect of Insulin Glulisine Compared to Insulin Aspart and Insulin Lispro When Administered by Continuous Subcutaneous Insulin Infusion (CSII) on Specific Pump Parameters in Patient With Type 1 Diabetes Mellitus

Sanofi

NCT00607087

COMPLETED NA 273 participants

Post Approval Study of the Eversense® Continuous Glucose Monitoring

Senseonics

NCT03908125

COMPLETED NA 250 participants

Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose

Becton, Dickinson and Company

NCT00741390

COMPLETED Phase 3 242 participants

Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in Diabetics

Novo Nordisk A/S

NCT00773279

COMPLETED NA 222 participants

Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions

Duke University

NCT03938324

COMPLETED NA 157 participants

Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign

Scripps Whittier Diabetes Institute

NCT03068273

COMPLETED NA 131 participants

Day and Night Closed-loop in Young People With Type 1 Diabetes

Jaeb Center for Health Research

NCT02925299

COMPLETED NA 120 participants

Pilot Study of Brief Intervention to Support Diabetes Health-Related Quality of Life

Baylor College of Medicine

NCT05234944

COMPLETED Phase 1 115 participants

Evaluation of TTP399 in Patients With Type 1 Diabetes

vTv Therapeutics

NCT03335371

COMPLETED Phase 2 110 participants

Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy

Sangamo Therapeutics

NCT00406458

COMPLETED NA 103 participants

Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial

Tandem Diabetes Care

NCT03195140

COMPLETED Phase 2 91 participants

Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy

Sangamo Therapeutics

NCT00476931

COMPLETED 85 participants

Clinical Startup of the 670G Closed Loop Insulin Delivery System

Stanford University

NCT03017482

COMPLETED 79 participants

Assessment of Mealtime Bolus Insulin Behavior

Eli Lilly and Company

NCT03368807

COMPLETED Phase 3 77 participants

Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults

Eli Lilly and Company

NCT01994746

COMPLETED Phase 1 76 participants

Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00813228

COMPLETED NA 73 participants

Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index

University of Virginia

NCT02663661

COMPLETED NA 70 participants

Diabetes Visual Function Supplement Study

ZeaVision

NCT01646047

COMPLETED NA 68 participants

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

University of North Carolina, Chapel Hill

NCT03651622

COMPLETED Phase 4 62 participants

Comparison of Glycemic Control Achieved With 2 Different Needles

Novo Nordisk A/S

NCT00572052

COMPLETED Phase 1 50 participants

Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function

University of Colorado, Denver

NCT03618420

COMPLETED 49 participants

Green Digital Diabetes Waste Project

Florida State University

NCT06071325

COMPLETED Phase 2 48 participants

Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus

Halozyme Therapeutics

NCT00883558

COMPLETED NA 48 participants

A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas

Massachusetts General Hospital

NCT02092220

COMPLETED NA 47 participants

Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)

University of Minnesota

NCT03410277

COMPLETED Phase 2 46 participants

Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control

Diasome Pharmaceuticals

NCT03096392

COMPLETED NA 41 participants

Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus

University of Virginia

NCT00943787

COMPLETED NA 41 participants

Pilot Study of Connected Diabetes Technology

University of California, Davis

NCT04106440

COMPLETED Phase 3 37 participants

A Trial Evaluating Compatibility and Safety of FIAsp and Insulin Aspart With an External Continuous Subcutaneous Insulin Infusion System in Adult Subjects With Type 1 Diabetes

Novo Nordisk A/S

NCT01999322

COMPLETED Phase 1 37 participants

A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes

Pfizer

NCT02038764

COMPLETED NA 37 participants

Medtronic Minimed Overnight Closed-Loop System

Bruce A. Buckingham

NCT01881009

COMPLETED NA 32 participants

Diabetes Assistant (DiAs) Control-to-Range (CTR) Nocturnal Closed-Loop Camp Study

University of Virginia

NCT01973413

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 14
Phase 3 23
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 1 Trial Landscape

119 indexed Diabetes Mellitus, Type 1 studies · 39 recruiting (33%).

Phase mix: 31 late (III/IV) vs 27 early (I/II).

Top sponsor: Novo Nordisk A/S (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 1?

PlainTrial tracks 119 US clinical trials for Diabetes Mellitus, Type 1, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 1?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.