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NCT04061746 · ClinicalTrials.gov registry record · Phase 1
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
A Phase 1 study of Diabetes Mellitus, Type 1, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT04061746: Recruiting Phase 1 study of Diabetes Mellitus, Type 1, sponsored by Medical University of South Carolina.
NCT04061746 is a Phase 1 study of Diabetes Mellitus, Type 1 that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 60 participants, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04061746, a Phase 1 study of Diabetes Mellitus, Type 1, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to understand the mechanisms of protection. If proven effective, such a strategy can be used as a therapeutic option for T1D patients and potentially other autoimmune disorders.
Primary Outcome
Change in beta cell function
Conditions Studied
Interventions
- BIOLOGICAL Mesenchymal Stem Cells (MSCs)
- OTHER Placebo Infusion (Plasmalyte A with 0.5% human serum albumin)
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2020-02-27 |
| Est. Completion | 2027-03-31 |
| Phase | Phase 1 |
What NCT04061746 shows while recruiting
NCT04061746 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,266-participant average among 118 other Diabetes Mellitus, Type 1 trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Diabetes Mellitus, Type 1 appearing as the primary indexed condition, and to 2 interventions - of which Mesenchymal Stem Cells (MSCs) is the first listed.
NCT04061746 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT04061746 about?
NCT04061746 is a clinical study titled "Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells". The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to understand the mechanisms of protection. If proven effective, such a strategy...
What is the current status of trial NCT04061746?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2020-02-27. Estimated completion is 2027-03-31.
What conditions does trial NCT04061746 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 1.
What interventions are being tested in trial NCT04061746?
The interventions under investigation include: Mesenchymal Stem Cells (MSCs) (BIOLOGICAL), Placebo Infusion (Plasmalyte A with 0.5% human serum albumin) (OTHER).
Who is sponsoring clinical trial NCT04061746?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04061746 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetes Mellitus, Type 1
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04061746's enrollment target sits among peer trials
60 64th of 118 higher than 53 of 118 other Diabetes Mellitus, Type 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes Mellitus, Type 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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