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ClinicalTrials.gov 5 recruiting now official registry

Aortic Valve Disease clinical trials

Every US clinical trial registered for Aortic Valve Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

16 US clinical trials · 5 currently recruiting

The research picture

Aortic Valve Disease has 16 registered US clinical trials, 5 of them open to new participants right now — about 31% of the total.

5
recruiting participants now
31%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Abbott Medical Devices

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 260 participants

Valved Graft PMCF Study

Abbott Medical Devices

NCT04754217

RECRUITING 225 participants

Prospective Long-Term Outcomes of a Standardized Ross Procedure

Baylor Research Institute

NCT06352671

RECRUITING NA 200 participants

CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation

University of Colorado, Denver

NCT07008911

RECRUITING NA 50 participants

The JenaValve ALIGN-AR LVAD Registry

JenaValve Technology

NCT06594705

RECRUITING NA 20 participants

Quantification of Debris Captured Using TCEP During VIV TAVR With BVF

Saint Luke's Health System

NCT05093764

ACTIVE NOT RECRUITING 3,000 participants

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

Yale University

NCT03440697

ACTIVE NOT RECRUITING 1,000 participants

Identification of Genetic Causes of Calcific Aortic Valve Disease

Beth Israel Deaconess Medical Center

NCT04149600

ACTIVE NOT RECRUITING NA 532 participants

Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

Emblok

NCT05295628

ACTIVE NOT RECRUITING NA 190 participants

Avalus Ultra Post-Approval Study (PAS)

Medtronic Cardiac Surgery

NCT06506903

ACTIVE NOT RECRUITING NA 180 participants

The JenaValve ALIGN-AR Pivotal Trial

JenaValve Technology

NCT04415047

ACTIVE NOT RECRUITING 108 participants

Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)

JOTEC

NCT05082454

ACTIVE NOT RECRUITING NA 40 participants

Early Feasibility Study for the Foldax Tria Aortic Heart Valve

Foldax

NCT03851068

ACTIVE NOT RECRUITING NA 25 participants

J-Valve TF Early Feasibility Study

JC Medical, Inc., an affiliate of Edwards Lifesciences

NCT06034028

ACTIVE NOT RECRUITING 20 participants

SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy

Abbott Medical Devices

NCT03924661

COMPLETED 273,365 participants

Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease

Duke University

NCT02266251

COMPLETED NA 40 participants

Optimization Post-TAVR to IMprove Activity Levels (OPTIMAL Study)

Johns Hopkins University

NCT06106451

Phase Distribution

Phase data not available

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aortic Valve Disease Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under Aortic Valve Disease, and 5 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Aortic Valve Disease shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Aortic Valve Disease is led by Abbott Medical Devices with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aortic Valve Disease?

PlainTrial tracks 16 US clinical trials for Aortic Valve Disease, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aortic Valve Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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