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Aortic Valve Disease clinical trials
Every US clinical trial registered for Aortic Valve Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
16 US clinical trials · 5 currently recruiting
The research picture
Aortic Valve Disease has 16 registered US clinical trials, 5 of them open to new participants right now — about 31% of the total.
- 5
- recruiting participants now
- 31%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Abbott Medical Devices
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Valved Graft PMCF Study
Abbott Medical Devices
NCT04754217
Prospective Long-Term Outcomes of a Standardized Ross Procedure
Baylor Research Institute
NCT06352671
CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation
University of Colorado, Denver
NCT07008911
The JenaValve ALIGN-AR LVAD Registry
JenaValve Technology
NCT06594705
Quantification of Debris Captured Using TCEP During VIV TAVR With BVF
Saint Luke's Health System
NCT05093764
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
Yale University
NCT03440697
Identification of Genetic Causes of Calcific Aortic Valve Disease
Beth Israel Deaconess Medical Center
NCT04149600
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Emblok
NCT05295628
Avalus Ultra Post-Approval Study (PAS)
Medtronic Cardiac Surgery
NCT06506903
The JenaValve ALIGN-AR Pivotal Trial
JenaValve Technology
NCT04415047
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
JOTEC
NCT05082454
Early Feasibility Study for the Foldax Tria Aortic Heart Valve
Foldax
NCT03851068
J-Valve TF Early Feasibility Study
JC Medical, Inc., an affiliate of Edwards Lifesciences
NCT06034028
SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy
Abbott Medical Devices
NCT03924661
Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease
Duke University
NCT02266251
Optimization Post-TAVR to IMprove Activity Levels (OPTIMAL Study)
Johns Hopkins University
NCT06106451
Phase Distribution
Phase data not available
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Aortic Valve Disease Trial Landscape
ClinicalTrials.gov lists 16 US studies indexed under Aortic Valve Disease, and 5 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Aortic Valve Disease shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Aortic Valve Disease is led by Abbott Medical Devices with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Aortic Valve Disease?
PlainTrial tracks 16 US clinical trials for Aortic Valve Disease, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Aortic Valve Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.